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Hck hemopoietic cell kinase [ Mus musculus (house mouse) ]

Gene ID: 15162, updated on 8-Feb-2024

Summary

Official Symbol
Hckprovided by MGI
Official Full Name
hemopoietic cell kinaseprovided by MGI
Primary source
MGI:MGI:96052
See related
Ensembl:ENSMUSG00000003283 AllianceGenome:MGI:96052
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bmk
Summary
The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may play a role in the innate immune response and the STAT5 signaling pathway. Alternative translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization. [provided by RefSeq, Feb 2010]
Expression
Biased expression in spleen adult (RPKM 38.8), lung adult (RPKM 21.0) and 14 other tissues See more
Orthologs
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Genomic context

See Hck in Genome Data Viewer
Location:
2 H1; 2 75.41 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152950388..152993361)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (153108468..153151441)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene X-linked Kx blood group related 7 Neighboring gene predicted gene, 32286 Neighboring gene cerebral cavernous malformation 2-like Neighboring gene STARR-positive B cell enhancer ABC_E1605 Neighboring gene STARR-seq mESC enhancer starr_06087 Neighboring gene STARR-seq mESC enhancer starr_06088 Neighboring gene transmembrane 9 superfamily member 4 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene Neighboring gene TSPY-like 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC18625

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within defense response to Gram-positive bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in localization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of podosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosine-protein kinase HCK
Names
B cell/myeloid kinase
hematopoietic cell kinase
p56-HCK/p59-HCK
NP_001165588.1
NP_034537.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172117.1NP_001165588.1  tyrosine-protein kinase HCK isoform p56Hck

    See identical proteins and their annotated locations for NP_001165588.1

    Status: REVIEWED

    Description
    Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons, as demonstrated in PMID:1875927. The longer isoform (p59Hck) is derived from an upstream non-AUG (CUG) start codon, while the shorter isoform (p56Hck) is derived from a downstream AUG start codon. The shorter isoform (p56Hck) is represented in this RefSeq.
    Source sequence(s)
    AI849071, AK150290, BY157889
    Consensus CDS
    CCDS50756.1
    UniProtKB/TrEMBL
    F6UND7
    Related
    ENSMUSP00000105423.2, ENSMUST00000109799.8
    Conserved Domains (4) summary
    cd10363
    Location:117220
    SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
    pfam07714
    Location:239488
    Pkinase_Tyr; Protein tyrosine kinase
    cl17036
    Location:59114
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:231501
    PKc_like; Protein Kinases, catalytic domain
  2. NM_010407.4NP_034537.2  tyrosine-protein kinase HCK isoform p59Hck

    See identical proteins and their annotated locations for NP_034537.2

    Status: REVIEWED

    Description
    Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons, as demonstrated in PMID:1875927. The longer isoform (p59Hck) is derived from an upstream non-AUG (CUG) start codon, while the shorter isoform (p56Hck) is derived from a downstream AUG start codon. The longer isoform (p59Hck) is represented in this RefSeq.
    Source sequence(s)
    AI849071, AK150290, BY157889
    Consensus CDS
    CCDS38284.1
    UniProtKB/Swiss-Prot
    P08103, Q0VH03, Q3UD17
    UniProtKB/TrEMBL
    F6UND7
    Related
    ENSMUSP00000003370.8, ENSMUST00000003370.14
    Conserved Domains (4) summary
    cd10363
    Location:138241
    SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
    pfam07714
    Location:260509
    Pkinase_Tyr; Protein tyrosine kinase
    cl17036
    Location:80135
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:252522
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152950388..152993361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)