Hck Hck proto-oncogene, Src family tyrosine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hckprovided by MGI
Official Full Name: Hck proto-oncogene, Src family tyrosine kinaseprovided by MGI
Primary source: MGI:MGI:96052
See related: Ensembl:ENSMUSG00000003283 AllianceGenome:MGI:96052
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bmk
Summary: The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may play a role in the innate immune response and the STAT5 signaling pathway. Alternative translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization. [provided by RefSeq, Feb 2010]
Expression: Biased expression in spleen adult (RPKM 38.8), lung adult (RPKM 21.0) and 14 other tissues See more
Orthologs: all
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Genomic context

Location:: 2 H1; 2 75.41 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (152950388..152993361)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (153108468..153151441)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy.
Title: HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy.
Inhibition of HCK in myeloid cells restricts pancreatic tumor growth and metastasis.
Title: Inhibition of HCK in myeloid cells restricts pancreatic tumor growth and metastasis.
Hematopoietic cell kinase enhances osteosarcoma development via the MEK/ERK pathway.
Title: Hematopoietic cell kinase enhances osteosarcoma development via the MEK/ERK pathway.
Genetic Ablation of Hematopoietic Cell Kinase Accelerates Alzheimer's Disease-Like Neuropathology in Tg2576 Mice.
Title: Genetic Ablation of Hematopoietic Cell Kinase Accelerates Alzheimer's Disease-Like Neuropathology in Tg2576 Mice.
Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly.
Title: Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly.
Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice.
Title: Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice.
Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice.
Title: Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice.
These results suggest that the estrogen-autophagy-STAT3-HCK axis participates in the differentiation of PTGS2(high) IFNG(low) PRF1(low) GZMB(low) FCGR3(-) NK cells in ectopic lesion microenvironment.
Title: Suppression of autophagy and HCK signaling promotes PTGS2(high) FCGR3(-) NK cell differentiation triggered by ectopic endometrial stromal cells.
the Hck, Fgr and Lyn kinases are also necessary for amastigote uptake by macrophages. Src-mediated Arg activation is required for efficient uptake.
Title: The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.
Hematopoietic Hck promotes tumorigenesis.
Title: Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (5)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hck (e-PCR), detects polymorphism
- UniSTS:498433

HCK (e-PCR)
- UniSTS:253721

AI849071 (e-PCR)
- UniSTS:178742

J03023 (e-PCR)
- UniSTS:124850

UniSTS:498385 (e-PCR)
- UniSTS:498385

Hck (e-PCR), detects polymorphism
- UniSTS:498385

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of podosome assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of podosome assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of podosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
colocalizes_with actin filament	IEA Inferred from Electronic Annotation more info
colocalizes_with actin filament	ISO Inferred from Sequence Orthology more info
colocalizes_with actin filament	ISS Inferred from Sequence or Structural Similarity more info
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tyrosine-protein kinase HCK

Names: B cell/myeloid kinase; hematopoietic cell kinase; hemopoietic cell kinase; p56-HCK/p59-HCK

NP_001165588.1

EC 2.7.10.2

NP_034537.2

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001172117.1 → NP_001165588.1 tyrosine-protein kinase HCK isoform p56Hck

See identical proteins and their annotated locations for NP_001165588.1

Status: REVIEWED

Description

Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons, as demonstrated in PMID:1875927. The longer isoform (p59Hck) is derived from an upstream non-AUG (CUG) start codon, while the shorter isoform (p56Hck) is derived from a downstream AUG start codon. The shorter isoform (p56Hck) is represented in this RefSeq.

Source sequence(s)

AI849071, AK150290, BY157889

Consensus CDS

CCDS50756.1

UniProtKB/TrEMBL

F6UND7

Related

ENSMUSP00000105423.2, ENSMUST00000109799.8

Conserved Domains (4) summary

cd10363
Location:117 → 220

SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK

pfam07714
Location:239 → 488

Pkinase_Tyr; Protein tyrosine kinase

cl17036
Location:59 → 114

SH3; Src Homology 3 domain superfamily

cl21453
Location:231 → 501

PKc_like; Protein Kinases, catalytic domain
NM_010407.4 → NP_034537.2 tyrosine-protein kinase HCK isoform p59Hck

See identical proteins and their annotated locations for NP_034537.2

Status: REVIEWED

Description

Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons, as demonstrated in PMID:1875927. The longer isoform (p59Hck) is derived from an upstream non-AUG (CUG) start codon, while the shorter isoform (p56Hck) is derived from a downstream AUG start codon. The longer isoform (p59Hck) is represented in this RefSeq.

Source sequence(s)

AI849071, AK150290, BY157889

Consensus CDS

CCDS38284.1

UniProtKB/Swiss-Prot

P08103, Q0VH03, Q3UD17

UniProtKB/TrEMBL

F6UND7

Related

ENSMUSP00000003370.8, ENSMUST00000003370.14

Conserved Domains (4) summary

cd10363
Location:138 → 241

SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK

pfam07714
Location:260 → 509

Pkinase_Tyr; Protein tyrosine kinase

cl17036
Location:80 → 135

SH3; Src Homology 3 domain superfamily

cl21453
Location:252 → 522

PKc_like; Protein Kinases, catalytic domain