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WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 [ Homo sapiens (human) ]

Gene ID: 151525, updated on 21-Dec-2019

Summary

Official Symbol
WDSUB1provided by HGNC
Official Full Name
WD repeat, sterile alpha motif and U-box domain containing 1provided by HGNC
Primary source
HGNC:HGNC:26697
See related
Ensembl:ENSG00000196151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBOX6; WDSAM1
Expression
Ubiquitous expression in thyroid (RPKM 5.8), kidney (RPKM 5.0) and 25 other tissues See more
Orthologs

Genomic context

See WDSUB1 in Genome Data Viewer
Location:
2q24.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (159235793..159286793, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (160092304..160143304, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 Neighboring gene glutathione S-transferase mu 3 pseudogene 2 Neighboring gene uncharacterized LOC105373716 Neighboring gene microRNA 6888 Neighboring gene bromodomain adjacent to zinc finger domain 2B Neighboring gene CAPZA1 pseudogene 2 Neighboring gene uncharacterized LOC643072

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36175, 2610014F08Rik

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
WD repeat, SAM and U-box domain-containing protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128212.3NP_001121684.1  WD repeat, SAM and U-box domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001121684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1.
    Source sequence(s)
    AK093494, AL040518, CB240898, DR000438
    Consensus CDS
    CCDS2208.1
    UniProtKB/Swiss-Prot
    Q8N9V3
    UniProtKB/TrEMBL
    D3DPA6
    Related
    ENSP00000352820.4, ENST00000359774.8
    Conserved Domains (6) summary
    cd09505
    Location:328399
    SAM_WDSUB1; SAM domain of WDSUB1 proteins
    smart00454
    Location:332395
    SAM; Sterile alpha motif
    COG2319
    Location:2308
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:4309
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam04564
    Location:404476
    U-box; U-box domain
    sd00039
    Location:1652
    7WD40; WD40 repeat [structural motif]
  2. NM_001128213.2NP_001121685.1  WD repeat, SAM and U-box domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001121685.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC008277, AK129983, AL040518, CB240898
    Consensus CDS
    CCDS2208.1
    UniProtKB/TrEMBL
    D3DPA6
    Related
    ENSP00000387078.3, ENST00000409990.7
    Conserved Domains (6) summary
    cd09505
    Location:328399
    SAM_WDSUB1; SAM domain of WDSUB1 proteins
    smart00454
    Location:332395
    SAM; Sterile alpha motif
    COG2319
    Location:2308
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:4309
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam04564
    Location:404476
    U-box; U-box domain
    sd00039
    Location:1652
    7WD40; WD40 repeat [structural motif]
  3. NM_001307994.2NP_001294923.1  WD repeat, SAM and U-box domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001294923.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks several exons in the central coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1, but maintains the same N- and C-termini.
    Source sequence(s)
    AK093494, BC029520
    Consensus CDS
    CCDS77477.1
    UniProtKB/Swiss-Prot
    Q8N9V3
    Related
    ENSP00000350866.4, ENST00000358147.8
    Conserved Domains (6) summary
    cd09505
    Location:236307
    SAM_WDSUB1; SAM domain of WDSUB1 proteins
    smart00454
    Location:240303
    SAM; Sterile alpha motif
    COG2319
    Location:3253
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:3217
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam04564
    Location:312384
    U-box; U-box domain
    sd00039
    Location:1652
    7WD40; WD40 repeat [structural motif]
  4. NM_001330274.2NP_001317203.1  WD repeat, SAM and U-box domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008277, AC009307, KF456729
    Consensus CDS
    CCDS82525.1
    UniProtKB/TrEMBL
    B8ZZF2
    Related
    ENSP00000386891.1, ENST00000409124.1
    Conserved Domains (6) summary
    smart00454
    Location:332377
    SAM; Sterile alpha motif
    COG2319
    Location:2308
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:4309
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:1652
    7WD40; WD40 repeat [structural motif]
    cl15755
    Location:328377
    SAM_superfamily; SAM (Sterile alpha motif )
    cl17238
    Location:378429
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  5. NM_001330276.2NP_001317205.1  WD repeat, SAM and U-box domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008277, AC009307, KF456729
  6. NM_001330277.2NP_001317206.1  WD repeat, SAM and U-box domain-containing protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008277, AC009307, KF456729
    Conserved Domains (6) summary
    cd09505
    Location:241312
    SAM_WDSUB1; SAM domain of WDSUB1 proteins
    smart00454
    Location:245308
    SAM; Sterile alpha motif
    COG2319
    Location:15221
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:11224
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam04564
    Location:317389
    U-box; U-box domain
    sd00039
    Location:5791
    7WD40; WD40 repeat [structural motif]
  7. NM_001330278.2NP_001317207.1  WD repeat, SAM and U-box domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008277, AC009307, KF456729
    Consensus CDS
    CCDS2208.1
    UniProtKB/TrEMBL
    D3DPA6
    Conserved Domains (6) summary
    cd09505
    Location:328399
    SAM_WDSUB1; SAM domain of WDSUB1 proteins
    smart00454
    Location:332395
    SAM; Sterile alpha motif
    COG2319
    Location:2308
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:4309
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam04564
    Location:404476
    U-box; U-box domain
    sd00039
    Location:1652
    7WD40; WD40 repeat [structural motif]
  8. NM_001330279.2NP_001317208.1  WD repeat, SAM and U-box domain-containing protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC008277, AC009307, KF456729
    Conserved Domains (6) summary
    cd09505
    Location:159230
    SAM_WDSUB1; SAM domain of WDSUB1 proteins
    smart00454
    Location:163226
    SAM; Sterile alpha motif
    COG2319
    Location:7155
    WD40; WD40 repeat [General function prediction only]
    pfam04564
    Location:235307
    U-box; U-box domain
    sd00039
    Location:1568
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:1155
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  9. NM_001330280.2NP_001317209.1  WD repeat, SAM and U-box domain-containing protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC008277, AC009307, KF456729
    Conserved Domains (4) summary
    cd09505
    Location:90161
    SAM_WDSUB1; SAM domain of WDSUB1 proteins
    pfam04564
    Location:166238
    U-box; U-box domain
    cd16655
    Location:172210
    RING-Ubox_WDSUB1_like; U-box domain, a modified RING finger [structural motif]
    cl25539
    Location:2080
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  10. NM_152528.3NP_689741.2  WD repeat, SAM and U-box domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_689741.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1.
    Source sequence(s)
    AC008277, AK093494, AL040518, CB240898
    Consensus CDS
    CCDS2208.1
    UniProtKB/Swiss-Prot
    Q8N9V3
    UniProtKB/TrEMBL
    D3DPA6
    Related
    ENSP00000376545.3, ENST00000392796.7
    Conserved Domains (6) summary
    cd09505
    Location:328399
    SAM_WDSUB1; SAM domain of WDSUB1 proteins
    smart00454
    Location:332395
    SAM; Sterile alpha motif
    COG2319
    Location:2308
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:4309
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam04564
    Location:404476
    U-box; U-box domain
    sd00039
    Location:1652
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    159235793..159286793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452733.1XP_024308501.1  WD repeat, SAM and U-box domain-containing protein 1 isoform X2

    Conserved Domains (4) summary
    cd09505
    Location:90161
    SAM_WDSUB1; SAM domain of WDSUB1 proteins
    pfam04564
    Location:166238
    U-box; U-box domain
    cd16655
    Location:172210
    RING-Ubox_WDSUB1_like; U-box domain, a modified RING finger [structural motif]
    cl25539
    Location:2080
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_017003481.1XP_016858970.1  WD repeat, SAM and U-box domain-containing protein 1 isoform X1

RNA

  1. XR_001738651.1 RNA Sequence

  2. XR_922879.2 RNA Sequence

  3. XR_001738650.2 RNA Sequence

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