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Hc hemolytic complement [ Mus musculus (house mouse) ]

Gene ID: 15139, updated on 19-Feb-2024

Summary

Official Symbol
Hcprovided by MGI
Official Full Name
hemolytic complementprovided by MGI
Primary source
MGI:MGI:96031
See related
Ensembl:ENSMUSG00000026874 AllianceGenome:MGI:96031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C5; He; C5a; Hfib2
Summary
This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mice with a homozygous mutation in this gene exhibit impaired bone fracture healing and an enhanced inflammatory response in an allergic lung disease model. [provided by RefSeq, Nov 2015]
Expression
Biased expression in liver E18 (RPKM 32.3), liver adult (RPKM 24.7) and 4 other tissues See more
Orthologs
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Genomic context

Location:
2 B; 2 23.22 cM
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34873341..34958518, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34983329..35068506, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4439 Neighboring gene STARR-positive B cell enhancer ABC_E3370 Neighboring gene predicted gene, 52552 Neighboring gene STARR-positive B cell enhancer ABC_E7810 Neighboring gene predicted gene, 46733 Neighboring gene mitochondrial import receptor subunit TOM7 homolog Neighboring gene predicted gene 13449 Neighboring gene STARR-seq mESC enhancer starr_04276 Neighboring gene predicted gene, 39794 Neighboring gene expressed sequence AI182371 Neighboring gene STARR-positive B cell enhancer ABC_E4440 Neighboring gene centriolin Neighboring gene STARR-positive B cell enhancer ABC_E2616

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within complement activation, alternative pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within glomerulus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response to wounding IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within kidney development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neutrophil homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
part_of membrane attack complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
complement C5
Names
hepatic fibrogenesis 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010406.3NP_034536.3  complement C5 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AK080166, AL845534, M35525
    Consensus CDS
    CCDS15957.1
    UniProtKB/Swiss-Prot
    A2AS36, P06684
    Related
    ENSMUSP00000028233.4, ENSMUST00000028233.7
    Conserved Domains (8) summary
    COG2373
    Location:64614
    YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
    cd00017
    Location:686754
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:9991304
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    pfam01835
    Location:125219
    A2M_N; MG2 domain
    pfam00207
    Location:776863
    A2M; Alpha-2-macroglobulin family
    pfam07677
    Location:14231513
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:470610
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl02512
    Location:15311679
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    34873341..34958518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315669.2XP_017171158.1  complement C5 isoform X1

    Conserved Domains (10) summary
    cd00017
    Location:690758
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:10031308
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    pfam00207
    Location:780867
    A2M; Alpha-2-macroglobulin family
    pfam07677
    Location:14271517
    A2M_recep; A-macroglobulin receptor
    pfam17789
    Location:358461
    MG4; Macroglobulin domain MG4
    pfam17790
    Location:27124
    MG1; Macroglobulin domain MG1
    pfam17791
    Location:225309
    MG3; Macroglobulin domain MG3
    pfam01835
    Location:130223
    A2M_N; MG2 domain
    pfam07703
    Location:474614
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl02512
    Location:15351683
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...