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ERFE erythroferrone [ Homo sapiens (human) ]

Gene ID: 151176, updated on 23-Nov-2021

Summary

Official Symbol
ERFEprovided by HGNC
Official Full Name
erythroferroneprovided by HGNC
Primary source
HGNC:HGNC:26727
See related
Ensembl:ENSG00000178752 MIM:615099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTRP15; FAM132B; C1QTNF15
Expression
Biased expression in thyroid (RPKM 10.6), testis (RPKM 4.5) and 4 other tissues See more
Orthologs
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Genomic context

See ERFE in Genome Data Viewer
Location:
2q37.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (238158970..238168890)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (239067611..239077531)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene espin like Neighboring gene kelch like family member 30 Neighboring gene ILK associated serine/threonine phosphatase Neighboring gene long intergenic non-protein coding RNA 2610

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37034

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hormone activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular iron ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of fatty acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glucose import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
erythroferrone
Names
complement C1q tumor necrosis factor-related protein 15
family with sequence similarity 132, member B
myonectin
protein FAM132B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291832.2NP_001278761.1  erythroferrone precursor

    See identical proteins and their annotated locations for NP_001278761.1

    Status: VALIDATED

    Source sequence(s)
    AC016757, AI362696, BC047423, H05276, KF984314
    Consensus CDS
    CCDS77548.1
    UniProtKB/Swiss-Prot
    Q4G0M1
    Related
    ENSP00000442304.1, ENST00000546354.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    238158970..238168890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152521.1: Suppressed sequence

    Description
    NM_152521.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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