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CBWD2 COBW domain containing 2 [ Homo sapiens (human) ]

Gene ID: 150472, updated on 21-Dec-2019

Summary

Official Symbol
CBWD2provided by HGNC
Official Full Name
COBW domain containing 2provided by HGNC
Primary source
HGNC:HGNC:17907
See related
Ensembl:ENSG00000136682 MIM:611079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 10.0), skin (RPKM 7.9) and 25 other tissues See more

Genomic context

See CBWD2 in Genome Data Viewer
Location:
2q14.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (113437691..113496204)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (114195268..114253781)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373567 Neighboring gene uncharacterized LOC101927400 Neighboring gene uncharacterized LOC107985936 Neighboring gene uncharacterized LOC112268422 Neighboring gene long intergenic non-protein coding RNA 1961 Neighboring gene forkhead box D4 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
COBW domain-containing protein 2
Names
cobalamin synthase W domain-containing protein 2
cobalamin synthetase W domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330336.1NP_001317265.1  COBW domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC016745, AL078621
    Consensus CDS
    CCDS82502.1
    UniProtKB/TrEMBL
    C9J3G2
    Related
    ENSP00000411906.2, ENST00000416503.6
    Conserved Domains (3) summary
    COG0523
    Location:42357
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:255354
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001330337.1NP_001317266.1  COBW domain-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC016745, AL078621
    Conserved Domains (3) summary
    COG0523
    Location:42347
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:245344
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43181
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_001330339.1NP_001317268.1  COBW domain-containing protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC016745, AL078621
    Conserved Domains (3) summary
    COG0523
    Location:11340
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:238337
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:11171
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_001330340.1NP_001317269.1  COBW domain-containing protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC016745, AL078621
    Conserved Domains (2) summary
    pfam07683
    Location:106205
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:963
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. NM_001330342.1NP_001317271.1  COBW domain-containing protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC016745, AK225251, DA296279, DA347165
    Conserved Domains (2) summary
    pfam07683
    Location:106205
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:963
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. NM_172003.3NP_742000.1  COBW domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_742000.1

    Status: VALIDATED

    Source sequence(s)
    AK290072, DA296279
    Consensus CDS
    CCDS2116.1
    UniProtKB/Swiss-Prot
    Q8IUF1
    Related
    ENSP00000259199.4, ENST00000259199.9
    Conserved Domains (3) summary
    COG0523
    Location:42376
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:274373
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. NR_138473.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016745, AL078621
  2. NR_138474.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016745, AL078621
    Related
    ENST00000358604.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    113437691..113496204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510667.1XP_011508969.1  COBW domain-containing protein 2 isoform X2

    Conserved Domains (2) summary
    COG0523
    Location:42317
    YejR; GTPase, G3E family [General function prediction only]
    cl21455
    Location:43207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_005263604.2XP_005263661.1  COBW domain-containing protein 2 isoform X1

    Conserved Domains (3) summary
    COG0523
    Location:42328
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:226325
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43181
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_024452717.1XP_024308485.1  COBW domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    cl26870
    Location:1234
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain

RNA

  1. XR_244814.2 RNA Sequence

  2. XR_427073.2 RNA Sequence

  3. XR_922864.1 RNA Sequence

  4. XR_002959242.1 RNA Sequence

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