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ZNG1B Zn regulated GTPase metalloprotein activator 1B [ Homo sapiens (human) ]

Gene ID: 150472, updated on 29-Oct-2022

Summary

Official Symbol
ZNG1Bprovided by HGNC
Official Full Name
Zn regulated GTPase metalloprotein activator 1Bprovided by HGNC
Primary source
HGNC:HGNC:17907
See related
Ensembl:ENSG00000136682 MIM:611079; AllianceGenome:HGNC:17907
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBWD2
Summary
Predicted to enable ATP binding activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 10.0), skin (RPKM 7.9) and 25 other tissues See more
Orthologs
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Genomic context

See ZNG1B in Genome Data Viewer
Location:
2q14.1
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (113437691..113496204)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (113862219..113920733)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (114195268..114253781)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2966 Neighboring gene uncharacterized LOC107985936 Neighboring gene immunoglobulin kappa variable 1-39-like Neighboring gene long intergenic non-protein coding RNA 1961 Neighboring gene forkhead box D4 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zinc-regulated GTPase metalloprotein activator 1B; COBW domain-containing protein 2
Names
COBW domain containing 2
cobalamin synthase W domain-containing protein 2
cobalamin synthetase W domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330336.1NP_001317265.1  zinc-regulated GTPase metalloprotein activator 1B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC016745, AL078621
    Consensus CDS
    CCDS82502.1
    UniProtKB/TrEMBL
    C9J3G2
    Related
    ENSP00000411906.2, ENST00000416503.6
    Conserved Domains (3) summary
    COG0523
    Location:42357
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:255354
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001330337.1NP_001317266.1  zinc-regulated GTPase metalloprotein activator 1B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC016745, AL078621
    Conserved Domains (3) summary
    COG0523
    Location:42347
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:245344
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43181
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_001330339.1NP_001317268.1  zinc-regulated GTPase metalloprotein activator 1B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC016745, AL078621
    Conserved Domains (3) summary
    COG0523
    Location:11340
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:238337
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:11171
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_001330340.1NP_001317269.1  zinc-regulated GTPase metalloprotein activator 1B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC016745, AL078621
    Conserved Domains (2) summary
    pfam07683
    Location:106205
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:963
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. NM_001330342.1NP_001317271.1  zinc-regulated GTPase metalloprotein activator 1B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC016745, AK225251, DA296279, DA347165
    Conserved Domains (2) summary
    pfam07683
    Location:106205
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:963
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. NM_172003.3NP_742000.1  zinc-regulated GTPase metalloprotein activator 1B isoform 1

    See identical proteins and their annotated locations for NP_742000.1

    Status: VALIDATED

    Source sequence(s)
    AK290072, DA296279
    Consensus CDS
    CCDS2116.1
    UniProtKB/Swiss-Prot
    Q0VAN3, Q8IUF1
    Related
    ENSP00000259199.4, ENST00000259199.9
    Conserved Domains (3) summary
    COG0523
    Location:42376
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:274373
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. NR_138473.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016745, AL078621
  2. NR_138474.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016745, AL078621
    Related
    ENST00000358604.7

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    113437691..113496204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510667.2XP_011508969.1  COBW domain-containing protein 2 isoform X3

    Conserved Domains (2) summary
    COG0523
    Location:42317
    YejR; GTPase, G3E family [General function prediction only]
    cl21455
    Location:43207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_005263604.3XP_005263661.1  COBW domain-containing protein 2 isoform X1

    Conserved Domains (3) summary
    COG0523
    Location:42328
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:226325
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43181
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_047443448.1XP_047299404.1  COBW domain-containing protein 2 isoform X2

RNA

  1. XR_244814.2 RNA Sequence

  2. XR_427073.2 RNA Sequence

  3. XR_007069657.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    113862219..113920733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)