U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

H2-M9 histocompatibility 2, M region locus 9 [ Mus musculus (house mouse) ]

Gene ID: 14997, updated on 11-Apr-2024

Summary

Official Symbol
H2-M9provided by MGI
Official Full Name
histocompatibility 2, M region locus 9provided by MGI
Primary source
MGI:MGI:1276570
See related
Ensembl:ENSMUSG00000067201 AllianceGenome:MGI:1276570
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M9
Summary
Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in several cellular components, including bounding membrane of organelle; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in asthma; hepatitis C; and occupational asthma. Orthologous to human HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See H2-M9 in Genome Data Viewer
Location:
17 B1; 17 19.16 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36950169..36953598, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36639285..36642663, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, M region locus 11 Neighboring gene predicted gene 8868 Neighboring gene STARR-seq mESC enhancer starr_42490 Neighboring gene STARR-seq mESC enhancer starr_42491 Neighboring gene ribosomal protein L9, pseudogene 5 Neighboring gene histocompatibility 2, M region locus 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
 
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-2-microglobulin binding ISO
Inferred from Sequence Orthology
more info
 
enables natural killer cell lectin-like receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of MHC class I protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of MHC class Ib protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histocompatibility 2, M region locus 9

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368317.1NP_001355246.1  histocompatibility 2, M region locus 9 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AK080256
    Consensus CDS
    CCDS89091.1
    UniProtKB/TrEMBL
    Q8HWA1
    Related
    ENSMUSP00000084409.5, ENSMUST00000087165.11
  2. NM_008205.1NP_032231.1  histocompatibility 2, M region locus 9 isoform 2 precursor

    See identical proteins and their annotated locations for NP_032231.1

    Status: VALIDATED

    Source sequence(s)
    AF016308
    Consensus CDS
    CCDS28724.1
    UniProtKB/TrEMBL
    O19442, Q3B846
    Related
    ENSMUSP00000084411.5, ENSMUST00000087167.5
    Conserved Domains (2) summary
    cd07698
    Location:209299
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:25203
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    36950169..36953598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160328.1XP_036016221.1  histocompatibility 2, M region locus 9 isoform X1

    UniProtKB/TrEMBL
    Q3B846, Q85ZX1
    Conserved Domains (2) summary
    cd07698
    Location:207298
    IgC1_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain, alpha3 immunoglobulin domain; member of the C1-set of Ig superfamily (IgSF) domains
    cl08246
    Location:25203
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2