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H2-K1 histocompatibility 2, K1, K region [ Mus musculus (house mouse) ]

Gene ID: 14972, updated on 22-Aug-2021

Summary

Official Symbol
H2-K1provided by MGI
Official Full Name
histocompatibility 2, K1, K regionprovided by MGI
Primary source
MGI:MGI:95904
See related
Ensembl:ENSMUSG00000061232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K-f; H-2K; H2-K; H2-D1; H2-K_p; H-2K(d)
Expression
Broad expression in duodenum adult (RPKM 724.0), mammary gland adult (RPKM 712.4) and 17 other tissues See more
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Genomic context

See H2-K1 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34214986..34219321, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33996012..34000619, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34132957..34137278, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53998 Neighboring gene expressed sequence AA388235 Neighboring gene predicted gene, 53999 Neighboring gene Casitas B-lineage lymphoma pseudogene Neighboring gene ring finger protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC7052, MGC184092

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables CD8 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables MHC class I protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
 
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables TAP binding ISO
Inferred from Sequence Orthology
more info
 
enables TAP complex binding ISO
Inferred from Sequence Orthology
more info
 
enables TAP1 binding ISO
Inferred from Sequence Orthology
more info
 
enables TAP2 binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-2-microglobulin binding ISO
Inferred from Sequence Orthology
more info
 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables natural killer cell lectin-like receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide antigen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antigen processing and presentation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent IDA
Inferred from Direct Assay
more info
PubMed 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of peptide antigen via MHC class I IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inner ear development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi medial cisterna ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
part_of MHC class I peptide loading complex ISO
Inferred from Sequence Orthology
more info
 
part_of MHC class I protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of MHC class Ib protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cis-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of lumenal side of endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
H-2 class I histocompatibility antigen, K-W28 alpha chain
Names
H-2 class I histocompatibility antigen, K-B alpha chain
H-2 class I histocompatibility antigen, K-D alpha chain
H-2 class I histocompatibility antigen, K-K alpha chain
H-2 class I histocompatibility antigen, K-Q alpha chain
H-2K(B)
H-2K(K)
H-2K(Q)
MHC H2-K transplantation antigen
MHC class I H2-K-b-alpha-2 cell surface glycoprotein
MHC class I antigen
MHC class I heavy chain H2-K
MHC class I heavy chain heavy chain
MHC class I heavy chain maturation peptide
MHC class II antigen D
MHC class II antigen K
class I major histocompatibility antigen H-2Kd
histocompatibility 2, K region, promoter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001892.2NP_001001892.2  H-2 class I histocompatibility antigen, K-W28 alpha chain isoform 1 precursor

    See identical proteins and their annotated locations for NP_001001892.2

    Status: VALIDATED

    Source sequence(s)
    AK153419, BP757296
    Consensus CDS
    CCDS50069.1
    UniProtKB/Swiss-Prot
    P01901
    UniProtKB/TrEMBL
    Q7JJ15
    Related
    ENSMUSP00000025181.11, ENSMUST00000025181.18
    Conserved Domains (3) summary
    cd07698
    Location:204296
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:22200
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    pfam06623
    Location:335359
    MHC_I_C; MHC_I C-terminus
  2. NM_001347346.1NP_001334275.1  H-2 class I histocompatibility antigen, K-W28 alpha chain isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AK168517, BP757296, CR974462
    Consensus CDS
    CCDS84295.1
    UniProtKB/TrEMBL
    Q3TH01
    Related
    ENSMUSP00000134004.2, ENSMUST00000172912.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34214986..34219321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249506.2XP_030105366.1  H-2 class I histocompatibility antigen, K-W28 alpha chain isoform X8

    Conserved Domains (3) summary
    cd07698
    Location:204296
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:23200
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    pfam06623
    Location:340362
    MHC_I_C; MHC_I C-terminus
  2. XM_030249505.2XP_030105365.1  H-2 class I histocompatibility antigen, K-W28 alpha chain isoform X2

    Related
    ENSMUST00000114311.11
    Conserved Domains (2) summary
    cd07698
    Location:204296
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:23200
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  3. XM_006523678.5XP_006523741.1  H-2 class I histocompatibility antigen, K-W28 alpha chain isoform X7

    See identical proteins and their annotated locations for XP_006523741.1

    Conserved Domains (3) summary
    cd07698
    Location:224316
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:43220
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    pfam06623
    Location:355377
    MHC_I_C; MHC_I C-terminus
  4. XM_006523676.5XP_006523739.1  H-2 class I histocompatibility antigen, K-W28 alpha chain isoform X5

    See identical proteins and their annotated locations for XP_006523739.1

    Conserved Domains (3) summary
    cd07698
    Location:224316
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:43220
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    pfam06623
    Location:355377
    MHC_I_C; MHC_I C-terminus
  5. XM_006523677.5XP_006523740.1  H-2 class I histocompatibility antigen, K-W28 alpha chain isoform X6

    See identical proteins and their annotated locations for XP_006523740.1

    Conserved Domains (3) summary
    cd07698
    Location:224316
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:43220
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    pfam06623
    Location:360382
    MHC_I_C; MHC_I C-terminus
  6. XM_006523674.5XP_006523737.1  H-2 class I histocompatibility antigen, K-W28 alpha chain isoform X3

    See identical proteins and their annotated locations for XP_006523737.1

    Conserved Domains (3) summary
    cd07698
    Location:224316
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:43220
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    pfam06623
    Location:360382
    MHC_I_C; MHC_I C-terminus
  7. XM_006523673.5XP_006523736.1  H-2 class I histocompatibility antigen, K-W28 alpha chain isoform X1

    See identical proteins and their annotated locations for XP_006523736.1

    Conserved Domains (2) summary
    cd07698
    Location:224316
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:43220
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  8. XM_017317259.3XP_017172748.1  H-2 class I histocompatibility antigen, K-W28 alpha chain isoform X9

    Conserved Domains (3) summary
    cd07698
    Location:204296
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:23200
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    pfam06623
    Location:335357
    MHC_I_C; MHC_I C-terminus
  9. XM_017317258.3XP_017172747.1  H-2 class I histocompatibility antigen, K-W28 alpha chain isoform X4

    Conserved Domains (3) summary
    cd07698
    Location:224316
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00129
    Location:43220
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    pfam06623
    Location:355377
    MHC_I_C; MHC_I C-terminus
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