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NTMT2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 149281, updated on 7-Apr-2025

Summary

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Official Symbol
NTMT2provided by HGNC
Official Full Name
N-terminal Xaa-Pro-Lys N-methyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:31932
See related
Ensembl:ENSG00000203740 AllianceGenome:HGNC:31932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NTM1B; HOMT1B; C1orf184; METTL11B
Summary
Enables N-terminal protein N-methyltransferase activity. Involved in N-terminal protein amino acid methylation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
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Genomic context

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See NTMT2 in Genome Data Viewer
Location:
1q24.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (170145959..170168866)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (169501867..169524770)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (170115100..170138007)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene kinesin associated protein 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:169972353-169972990 Neighboring gene mitochondrial ribosomal protein S10 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1549 Neighboring gene sialic acid binding Ig like lectin 30, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:170114681-170115212 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:170115213-170115743 Neighboring gene microRNA 3119-1 Neighboring gene microRNA 3119-2 Neighboring gene long intergenic non-protein coding RNA 1681 Neighboring gene iron-sulfur cluster assembly enzyme pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1142

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1. Petkowski JJ, et al. Biochem J, 2013 Dec 15. PMID 24090352, Free PMC Article
  2. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. Treviño LR, et al. J Clin Oncol, 2009 Dec 10. PMID 19901119, Free PMC Article
  3. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-terminal protein N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-terminal protein N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-terminal protein amino acid methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-terminal Xaa-Pro-Lys N-methyltransferase 2
Names
X-Pro-Lys N-terminal protein methyltransferase 1B
alpha N-terminal protein methyltransferase 1B
methyltransferase like 11B
methyltransferase-like protein 11B
NP_001129579.1
XP_011507534.1
XP_011507535.1
XP_011507536.1
XP_054190616.1
XP_054190617.1
XP_054190618.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136107.2 → NP_001129579.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2

    See identical proteins and their annotated locations for NP_001129579.1

    Status: VALIDATED

    Source sequence(s)
    AL445203
    Consensus CDS
    CCDS44275.1
    UniProtKB/Swiss-Prot
    B2RXI0, Q5VVY1
    Related
    ENSP00000408058.3, ENST00000439373.3
    Conserved Domains (1) summary
    cl17173
    Location:67 → 277
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    170145959..170168866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509233.3 → XP_011507535.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_011507535.1

    Conserved Domains (1) summary
    cl17173
    Location:2 → 212
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_011509232.3 → XP_011507534.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_011507534.1

    Conserved Domains (1) summary
    cl17173
    Location:2 → 212
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. XM_011509234.3 → XP_011507536.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_011507536.1

    Conserved Domains (1) summary
    cl17173
    Location:2 → 212
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    169501867..169524770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334641.1 → XP_054190616.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

  2. XM_054334642.1 → XP_054190617.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

  3. XM_054334643.1 → XP_054190618.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VVY1.2 GenPept UniProtKB/Swiss-Prot:Q5VVY1

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