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NTMT2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 149281, updated on 7-Apr-2025

Summary

Official Symbol
NTMT2provided by HGNC
Official Full Name
N-terminal Xaa-Pro-Lys N-methyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:31932
See related
Ensembl:ENSG00000203740 AllianceGenome:HGNC:31932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NTM1B; HOMT1B; C1orf184; METTL11B
Summary
Enables N-terminal protein N-methyltransferase activity. Involved in N-terminal protein amino acid methylation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See NTMT2 in Genome Data Viewer
Location:
1q24.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (170145959..170168866)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (169501867..169524770)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (170115100..170138007)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene kinesin associated protein 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:169972353-169972990 Neighboring gene mitochondrial ribosomal protein S10 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1549 Neighboring gene sialic acid binding Ig like lectin 30, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:170114681-170115212 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:170115213-170115743 Neighboring gene microRNA 3119-1 Neighboring gene microRNA 3119-2 Neighboring gene long intergenic non-protein coding RNA 1681 Neighboring gene iron-sulfur cluster assembly enzyme pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1142

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Phenotypes

EBI GWAS Catalog

Description
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
EBI GWAS Catalog

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-terminal protein N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables N-terminal protein N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in N-terminal protein amino acid methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
N-terminal Xaa-Pro-Lys N-methyltransferase 2
Names
X-Pro-Lys N-terminal protein methyltransferase 1B
alpha N-terminal protein methyltransferase 1B
methyltransferase like 11B
methyltransferase-like protein 11B
NP_001129579.1
XP_011507534.1
XP_011507535.1
XP_011507536.1
XP_054190616.1
XP_054190617.1
XP_054190618.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136107.2NP_001129579.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2

    See identical proteins and their annotated locations for NP_001129579.1

    Status: VALIDATED

    Source sequence(s)
    AL445203
    Consensus CDS
    CCDS44275.1
    UniProtKB/Swiss-Prot
    B2RXI0, Q5VVY1
    Related
    ENSP00000408058.3, ENST00000439373.3
    Conserved Domains (1) summary
    cl17173
    Location:67277
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    170145959..170168866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509233.3XP_011507535.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_011507535.1

    Conserved Domains (1) summary
    cl17173
    Location:2212
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_011509232.3XP_011507534.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_011507534.1

    Conserved Domains (1) summary
    cl17173
    Location:2212
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. XM_011509234.3XP_011507536.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_011507536.1

    Conserved Domains (1) summary
    cl17173
    Location:2212
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    169501867..169524770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334641.1XP_054190616.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

  2. XM_054334642.1XP_054190617.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

  3. XM_054334643.1XP_054190618.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1