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DCDC2B doublecortin domain containing 2B [ Homo sapiens (human) ]

Gene ID: 149069, updated on 5-Mar-2024


Official Symbol
DCDC2Bprovided by HGNC
Official Full Name
doublecortin domain containing 2Bprovided by HGNC
Primary source
See related
Ensembl:ENSG00000222046 AllianceGenome:HGNC:32576
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. [provided by RefSeq, Sep 2010]
Broad expression in testis (RPKM 2.4), lung (RPKM 2.3) and 25 other tissues See more
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Genomic context

See DCDC2B in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (32209089..32216192)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32066991..32074095)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32674690..32681793)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene taxilin alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32664855-32665413 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32665414-32665971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 672 Neighboring gene coiled-coil domain containing 28B Neighboring gene H3K4me1 hESC enhancers GRCh37_chr1:32666522-32667041 and GRCh37_chr1:32667042-32667562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32670259-32670760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 675 Neighboring gene IQ motif containing C Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:32681346-32682545 Neighboring gene transmembrane protein 234 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:32687227-32688426 Neighboring gene eukaryotic translation initiation factor 3 subunit I Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:32698370-32698870 Neighboring gene myotubularin related protein 9 like, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 677 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 678 Neighboring gene family with sequence similarity 167 member B

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info

General protein information

Preferred Names
doublecortin domain-containing protein 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099434.2NP_001092904.1  doublecortin domain-containing protein 2B

    See identical proteins and their annotated locations for NP_001092904.1

    Status: REVIEWED

    Source sequence(s)
    AL049795, BC128073, BM980133
    Consensus CDS
    A2VCK2, B7ZBC6
    ENSP00000386870.1, ENST00000409358.2
    Conserved Domains (2) summary
    DCX; Ubiquitin-like domain of DCX
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060925.1 Alternate T2T-CHM13v2.0

    GenBank, FASTA, Sequence Viewer (Graphics)