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DCDC2B doublecortin domain containing 2B [ Homo sapiens (human) ]

Gene ID: 149069, updated on 5-Jan-2022

Summary

Official Symbol
DCDC2Bprovided by HGNC
Official Full Name
doublecortin domain containing 2Bprovided by HGNC
Primary source
HGNC:HGNC:32576
See related
Ensembl:ENSG00000222046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. [provided by RefSeq, Sep 2010]
Expression
Broad expression in testis (RPKM 2.4), lung (RPKM 2.3) and 25 other tissues See more
Orthologs
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Genomic context

See DCDC2B in Genome Data Viewer
Location:
1p35.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (32208813..32216192)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32674690..32681793)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 28B Neighboring gene transmembrane protein 234 Neighboring gene IQ motif containing C Neighboring gene eukaryotic translation initiation factor 3 subunit I Neighboring gene myotubularin related protein 9 like, pseudogene Neighboring gene family with sequence similarity 167 member B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
doublecortin domain-containing protein 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099434.2NP_001092904.1  doublecortin domain-containing protein 2B

    See identical proteins and their annotated locations for NP_001092904.1

    Status: REVIEWED

    Source sequence(s)
    AL049795, BC128073, BM980133
    Consensus CDS
    CCDS44100.1
    UniProtKB/Swiss-Prot
    A2VCK2
    Related
    ENSP00000386870.1, ENST00000409358.2
    Conserved Domains (2) summary
    cd01617
    Location:987
    DCX; Ubiquitin-like domain of DCX
    cl25424
    Location:131211
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    32208813..32216192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000413.1XP_016855902.1  doublecortin domain-containing protein 2B isoform X1

  2. XM_017000414.1XP_016855903.1  doublecortin domain-containing protein 2B isoform X2

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