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ORF1ab ORF1a polyprotein;ORF1ab polyprotein [ SARS coronavirus Tor2 ]

Gene ID: 1489680, updated on 7-Apr-2024

Summary

Gene symbol
ORF1ab
Gene description
ORF1a polyprotein;ORF1ab polyprotein
Locus tag
sarsp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
SARS coronavirus Tor2 (isolate: Tor2, nat-host: Homo sapiens; patient #2 with severe acute respiratory syndrome (SARS))
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
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Genomic context

Sequence:
NC_004718.3 (265..21485)

NC_004718.3Genomic Context describing neighboring genes Neighboring gene spike glycoprotein Neighboring gene ORF3a protein Neighboring gene ORF3b protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
ORF1a polyprotein;ORF1ab polyprotein
Names
polyprotein pp1a
polyprotein pp1ab
replicase 1AB
nsp1
nsp2
nsp3
nsp4
3C-like protease
nsp6
nsp7
nsp8
nsp9
nsp10
RNA-dependent RNA polymerase
helicase/NTPase
endoribonuclease
2'-O-MTase
3' to 5' exonuclease
nsp1
nsp2
nsp3
nsp4
3C-like protease
nsp6
nsp7
nsp8
nsp9
nsp10
ndp11
NP_828849.7
  • ORF1ab polyprotein is cleaved to yield the RNA-dependent RNA polymerase and other nonstructural proteins
YP_009944365.1
  • ORF1a polyprotein is cleaved to yield nonstructural proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004718.3 Reference assembly

    Range
    265..21485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_828849.7 ORF1ab polyprotein [SARS coronavirus Tor2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0C6X7, P59641, Q6WGN0, Q7T697, Q808C0, Q80BV7, Q80BV8, Q80E51
    UniProtKB/TrEMBL
    A7J8L2, B8Q8Q1, C4P6Q5, D3KDM3, J9T571, Q5Y189, Q6RCY9, Q6RD00, Q6RD11, Q6RD44, Q6RD66, Q6UZF5, Q6VA91, Q6VAA2
    Conserved Domains (29) summary
    pfam11633
    Location:13271469
    SUD-M; Single-stranded poly(A) binding domain
    cd21401
    Location:53025396
    ZBD_cv_Nsp13-like; Cys/His rich zinc-binding domain (CH/ZBD) of coronavirus SARS NSP13 helicase and related proteins
    cd21409
    Location:54515529
    1B_cv_Nsp13-like; 1B domain of coronavirus SARS NSP13 helicase and related proteins
    cd21473
    Location:27543134
    cv_Nsp4_TM; coronavirus non-structural protein 4 (Nsp4) transmembrane domain
    cd21525
    Location:14721538
    SUD_C_SARS-CoV_Nsp3; C-terminal SARS-Unique Domain (SUD) of non-structural protein 3 (Nsp3) from Severe Acute Respiratory Syndrome coronavirus and related betacoronaviruses in the B lineage
    cd21560
    Location:35473836
    betaCoV-Nsp6; betacoronavirus non-structural protein 6
    cd21516
    Location:182818
    cv_beta_Nsp2_SARS-like; betacoronavirus non-structural protein 2 (Nsp2) similar to SARS-CoV Nsp2, and related proteins from betacoronaviruses in the B lineage
    cd21557
    Location:10341155
    Macro_X_Nsp3-like; X-domain of viral non-structural protein 3 and related macrodomains
    cd21562
    Location:12091334
    Macro_cv_SUD-N_Nsp3-like; SUD-N macrodomain of the SARS Unique Domain (SUD) of SARS-CoV non-structural protein 3 and related macrodomains
    cd21666
    Location:32443540
    betaCoV_Nsp5_Mpro; betacoronavirus non-structural protein 5, also called Main protease (Mpro)
    cd21591
    Location:43755301
    SARS-CoV-like_RdRp; Severe acute respiratory syndrome coronavirus RNA-dependent RNA polymerase, also known as non-structural protein 12, and similar proteins from betacoronaviruses in the B lineage: responsible for replication and transcription of the viral RNA genome
    cd21171
    Location:64306490
    NTD_alpha_beta_cv_Nsp15-like; N-terminal domain of alpha- and beta-coronavirus Nonstructural protein 15 (Nsp15), and related proteins
    cd21167
    Location:64946625
    M_alpha_beta_cv_Nsp15-like; middle domain of alpha- and beta-coronavirus Nonstructural protein 15 (Nsp15), and related proteins
    cd21161
    Location:66236773
    NendoU_cv_Nsp15-like; Nidoviral uridylate-specific endoribonuclease (NendoU) domain of coronavirus Nonstructural Protein 15 (Nsp15) and related proteins
    cd21659
    Location:59076427
    betaCoV_Nsp14; nonstructural protein 14 of betacoronavirus
    pfam06460
    Location:67777072
    NSP13; Coronavirus NSP13
    pfam08717
    Location:39204116
    nsp8; nsp8 replicase
    pfam12379
    Location:8811029
    DUF3655; Protein of unknown function (DUF3655)
    pfam16348
    Location:31463238
    Corona_NSP4_C; Coronavirus nonstructural protein 4 C-terminus
    cd21827
    Location:38373919
    betaCoV_Nsp7; betacoronavirus non-structural protein 7
    cd21872
    Location:42314361
    CoV_Nsp10; coronavirus non-structural protein 10
    cd21898
    Location:41184230
    betaCoV_Nsp9; betacoronavirus non-structural protein 9
    cd21796
    Location:13127
    SARS-CoV-like_Nsp1_N; N-terminal domain of non-structural protein 1 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21822
    Location:18901996
    SARS-CoV-like_Nsp3_NAB; nucleic acid binding domain of non-structural protein 3 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21814
    Location:20212136
    SARS-CoV-like_Nsp3_betaSM; betacoronavirus-specific marker of non-structural protein 3 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21732
    Location:15431845
    betaCoV_PLPro; betacoronavirus papain-like protease
    cd21722
    Location:55525891
    betaCoV_Nsp13-helicase; helicase domain of betacoronavirus non-structural protein 13
    cd21717
    Location:22092739
    TM_Y_SARS-CoV-like_Nsp3_C; C-terminus of non-structural protein 3, including transmembrane and Y domains, from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21689
    Location:54005447
    stalk_CoV_Nsp13-like; stalk domain of coronavirus Nsp13 helicase and related proteins
  2. NP_828860.2 nsp1

    Conserved Domains (1) summary
    cd21796
    Location:13127
    SARS-CoV-like_Nsp1_N; N-terminal domain of non-structural protein 1 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
  3. NP_828861.2 nsp2

    Conserved Domains (1) summary
    cd21516
    Location:2638
    cv_beta_Nsp2_SARS-like; betacoronavirus non-structural protein 2 (Nsp2) similar to SARS-CoV Nsp2, and related proteins from betacoronaviruses in the B lineage
  4. NP_828862.2 nsp3

    Conserved Domains (9) summary
    pfam11633
    Location:509651
    SUD-M; Single-stranded poly(A) binding domain
    cd21525
    Location:654720
    SUD_C_SARS-CoV_Nsp3; C-terminal SARS-Unique Domain (SUD) of non-structural protein 3 (Nsp3) from Severe Acute Respiratory Syndrome coronavirus and related betacoronaviruses in the B lineage
    cd21557
    Location:214337
    Macro_X_Nsp3-like; X-domain of viral non-structural protein 3 and related macrodomains
    cd21562
    Location:391516
    Macro_cv_SUD-N_Nsp3-like; SUD-N macrodomain of the SARS Unique Domain (SUD) of SARS-CoV non-structural protein 3 and related macrodomains
    pfam12379
    Location:63211
    DUF3655; Protein of unknown function (DUF3655)
    cd21822
    Location:10721178
    SARS-CoV-like_Nsp3_NAB; nucleic acid binding domain of non-structural protein 3 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21814
    Location:12031318
    SARS-CoV-like_Nsp3_betaSM; betacoronavirus-specific marker of non-structural protein 3 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21732
    Location:7251027
    betaCoV_PLPro; betacoronavirus papain-like protease
    cd21717
    Location:13911921
    TM_Y_SARS-CoV-like_Nsp3_C; C-terminus of non-structural protein 3, including transmembrane and Y domains, from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
  5. NP_904322.1 nsp4

    Conserved Domains (2) summary
    cd21473
    Location:14394
    cv_Nsp4_TM; coronavirus non-structural protein 4 (Nsp4) transmembrane domain
    pfam16348
    Location:406498
    Corona_NSP4_C; Coronavirus nonstructural protein 4 C-terminus
  6. NP_828863.1 3C-like protease

    UniProtKB/TrEMBL
    G8H301
    Conserved Domains (1) summary
    cd21666
    Location:4300
    betaCoV_Nsp5_Mpro; betacoronavirus non-structural protein 5, also called Main protease (Mpro)
  7. NP_828864.1 nsp6

    Conserved Domains (1) summary
    cd21560
    Location:1290
    betaCoV-Nsp6; betacoronavirus non-structural protein 6
  8. NP_828865.1 nsp7

    Conserved Domains (1) summary
    cd21827
    Location:183
    betaCoV_Nsp7; betacoronavirus non-structural protein 7
  9. NP_828866.1 nsp8

    Conserved Domains (1) summary
    pfam08717
    Location:1197
    nsp8; nsp8 replicase
  10. NP_828867.1 nsp9

    Conserved Domains (1) summary
    cd21898
    Location:1113
    betaCoV_Nsp9; betacoronavirus non-structural protein 9
  11. NP_828868.1 nsp10

    UniProtKB/TrEMBL
    G8H302, G8H303
    Conserved Domains (1) summary
    cd21901
    Location:1131
    alpha_betaCoV_Nsp10; alphacoronavirus and betacoronavirus non-structural protein 14
  12. YP_009924301.1 RNA-dependent RNA polymerase

  13. NP_828870.1 helicase/NTPase

    Conserved Domains (3) summary
    COG1112
    Location:323592
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    cl21455
    Location:277407
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:443580
    UvrD_C_2; UvrD-like helicase C-terminal domain
  14. NP_828872.1 endoribonuclease

    Conserved Domains (3) summary
    cd21171
    Location:161
    NTD_alpha_beta_cv_Nsp15-like; N-terminal domain of alpha- and beta-coronavirus Nonstructural protein 15 (Nsp15), and related proteins
    cd21167
    Location:65196
    M_alpha_beta_cv_Nsp15-like; middle domain of alpha- and beta-coronavirus Nonstructural protein 15 (Nsp15), and related proteins
    cd21161
    Location:194344
    NendoU_cv_Nsp15-like; Nidoviral uridylate-specific endoribonuclease (NendoU) domain of coronavirus Nonstructural Protein 15 (Nsp15) and related proteins
  15. NP_828873.2 2'-O-MTase

    UniProtKB/TrEMBL
    G8H306
    Conserved Domains (1) summary
    pfam06460
    Location:2297
    NSP13; Coronavirus NSP13
  16. NP_828871.1 3' to 5' exonuclease

    Conserved Domains (1) summary
    cd21659
    Location:5525
    betaCoV_Nsp14; nonstructural protein 14 of betacoronavirus
  17. YP_009944365.1 ORF1a polyprotein [SARS coronavirus Tor2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0C6U8
    UniProtKB/TrEMBL
    A0A3G5BIY1, A7J8L3, B8Q8Q2, C4P6Q6, D2E1D1, D3KDM4, D3KDQ2, H9CHT9, J9SE37, J9T0Q3, J9TCC0, Q1EFN3, Q1EFP6, Q5Y188, Q6JH39, Q6JH47, Q6RCW6, Q6RCX7, Q6RCY8, Q6RCZ9, Q6RD10, Q6RD21, Q6RD32, Q6RD43, Q6RD65, Q6VA79, Q6VA90, Q6VAA1
    Conserved Domains (19) summary
    pfam11633
    Location:13271469
    SUD-M; Single-stranded poly(A) binding domain
    cd21473
    Location:27543134
    cv_Nsp4_TM; coronavirus non-structural protein 4 (Nsp4) transmembrane domain
    cd21525
    Location:14721538
    SUD_C_SARS-CoV_Nsp3; C-terminal SARS-Unique Domain (SUD) of non-structural protein 3 (Nsp3) from Severe Acute Respiratory Syndrome coronavirus and related betacoronaviruses in the B lineage
    cd21560
    Location:35473836
    betaCoV-Nsp6; betacoronavirus non-structural protein 6
    cd21516
    Location:182818
    cv_beta_Nsp2_SARS-like; betacoronavirus non-structural protein 2 (Nsp2) similar to SARS-CoV Nsp2, and related proteins from betacoronaviruses in the B lineage
    cd21557
    Location:10341155
    Macro_X_Nsp3-like; X-domain of viral non-structural protein 3 and related macrodomains
    cd21562
    Location:12091334
    Macro_cv_SUD-N_Nsp3-like; SUD-N macrodomain of the SARS Unique Domain (SUD) of SARS-CoV non-structural protein 3 and related macrodomains
    cd21666
    Location:32443540
    betaCoV_Nsp5_Mpro; betacoronavirus non-structural protein 5, also called Main protease (Mpro)
    pfam08717
    Location:39204116
    nsp8; nsp8 replicase
    pfam12379
    Location:8811029
    DUF3655; Protein of unknown function (DUF3655)
    pfam16348
    Location:31463238
    Corona_NSP4_C; Coronavirus nonstructural protein 4 C-terminus
    cd21827
    Location:38373919
    betaCoV_Nsp7; betacoronavirus non-structural protein 7
    cd21872
    Location:42314361
    CoV_Nsp10; coronavirus non-structural protein 10
    cd21898
    Location:41184230
    betaCoV_Nsp9; betacoronavirus non-structural protein 9
    cd21796
    Location:13127
    SARS-CoV-like_Nsp1_N; N-terminal domain of non-structural protein 1 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21822
    Location:18901996
    SARS-CoV-like_Nsp3_NAB; nucleic acid binding domain of non-structural protein 3 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21814
    Location:20212136
    SARS-CoV-like_Nsp3_betaSM; betacoronavirus-specific marker of non-structural protein 3 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21732
    Location:15431845
    betaCoV_PLPro; betacoronavirus papain-like protease
    cd21717
    Location:22092739
    TM_Y_SARS-CoV-like_Nsp3_C; C-terminus of non-structural protein 3, including transmembrane and Y domains, from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
  18. YP_009944366.1 nsp1

    Conserved Domains (1) summary
    cd21796
    Location:13127
    SARS-CoV-like_Nsp1_N; N-terminal domain of non-structural protein 1 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
  19. YP_009944367.1 nsp2

    Conserved Domains (1) summary
    cd21516
    Location:2638
    cv_beta_Nsp2_SARS-like; betacoronavirus non-structural protein 2 (Nsp2) similar to SARS-CoV Nsp2, and related proteins from betacoronaviruses in the B lineage
  20. YP_009944368.1 nsp3

    Conserved Domains (9) summary
    pfam11633
    Location:509651
    SUD-M; Single-stranded poly(A) binding domain
    cd21525
    Location:654720
    SUD_C_SARS-CoV_Nsp3; C-terminal SARS-Unique Domain (SUD) of non-structural protein 3 (Nsp3) from Severe Acute Respiratory Syndrome coronavirus and related betacoronaviruses in the B lineage
    cd21557
    Location:214337
    Macro_X_Nsp3-like; X-domain of viral non-structural protein 3 and related macrodomains
    cd21562
    Location:391516
    Macro_cv_SUD-N_Nsp3-like; SUD-N macrodomain of the SARS Unique Domain (SUD) of SARS-CoV non-structural protein 3 and related macrodomains
    pfam12379
    Location:63211
    DUF3655; Protein of unknown function (DUF3655)
    cd21822
    Location:10721178
    SARS-CoV-like_Nsp3_NAB; nucleic acid binding domain of non-structural protein 3 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21814
    Location:12031318
    SARS-CoV-like_Nsp3_betaSM; betacoronavirus-specific marker of non-structural protein 3 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21732
    Location:7251027
    betaCoV_PLPro; betacoronavirus papain-like protease
    cd21717
    Location:13911921
    TM_Y_SARS-CoV-like_Nsp3_C; C-terminus of non-structural protein 3, including transmembrane and Y domains, from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
  21. YP_009944369.1 nsp4

    Conserved Domains (2) summary
    cd21473
    Location:14394
    cv_Nsp4_TM; coronavirus non-structural protein 4 (Nsp4) transmembrane domain
    pfam16348
    Location:406498
    Corona_NSP4_C; Coronavirus nonstructural protein 4 C-terminus
  22. YP_009944370.1 3C-like protease

    UniProtKB/TrEMBL
    G8H301
    Conserved Domains (1) summary
    cd21666
    Location:4300
    betaCoV_Nsp5_Mpro; betacoronavirus non-structural protein 5, also called Main protease (Mpro)
  23. YP_009944371.1 nsp6

    Conserved Domains (1) summary
    cd21560
    Location:1290
    betaCoV-Nsp6; betacoronavirus non-structural protein 6
  24. YP_009944372.1 nsp7

    Conserved Domains (1) summary
    cd21827
    Location:183
    betaCoV_Nsp7; betacoronavirus non-structural protein 7
  25. YP_009944373.1 nsp8

    Conserved Domains (1) summary
    pfam08717
    Location:1197
    nsp8; nsp8 replicase
  26. YP_009944374.1 nsp9

    Conserved Domains (1) summary
    cd21898
    Location:1113
    betaCoV_Nsp9; betacoronavirus non-structural protein 9
  27. YP_009944375.1 nsp10

    UniProtKB/TrEMBL
    G8H302, G8H303
    Conserved Domains (1) summary
    cd21901
    Location:1131
    alpha_betaCoV_Nsp10; alphacoronavirus and betacoronavirus non-structural protein 14
  28. YP_009944376.1 ndp11