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ORF1ab ORF1a polyprotein;ORF1ab polyprotein [ SARS coronavirus Tor2 ]

Gene ID: 1489680, updated on 9-May-2021

Summary

Gene symbol
ORF1ab
Gene description
ORF1a polyprotein;ORF1ab polyprotein
Locus tag
sarsp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
SARS coronavirus Tor2 (isolate: Tor2, nat-host: Homo sapiens; patient #2 with severe acute respiratory syndrome (SARS))
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
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Genomic context

Sequence:
NC_004718.3 (265..21485)

NC_004718.3Genomic Context describing neighboring genes Neighboring gene spike glycoprotein Neighboring gene ORF3a protein Neighboring gene ORF3b protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
ORF1a polyprotein;ORF1ab polyprotein
Names
polyprotein pp1a
polyprotein pp1ab
replicase 1AB
nsp1
nsp2
nsp3
nsp4
3C-like protease
nsp6
nsp7
nsp8
nsp9
nsp10
RNA-dependent RNA polymerase
helicase/NTPase
endoribonuclease
2'-O-MTase
3' to 5' exonuclease
nsp1
nsp2
nsp3
nsp4
3C-like protease
nsp6
nsp7
nsp8
nsp9
nsp10
ndp11
NP_828849.7
  • ORF1ab polyprotein is cleaved to yield the RNA-dependent RNA polymerase and other nonstructural proteins
YP_009944365.1
  • ORF1a polyprotein is cleaved to yield nonstructural proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004718.3 Reference assembly

    Range
    265..21485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_828849.7 ORF1ab polyprotein [SARS coronavirus Tor2]

    Status: PROVISIONAL

    Conserved Domains (29) summary
    pfam11633
    Location:13271469
    SUD-M; Single-stranded poly(A) binding domain
    cd21401
    Location:53025396
    ZBD_cv_Nsp13-like; Cys/His rich zinc-binding domain (CH/ZBD) of coronavirus SARS NSP13 helicase and related proteins
    cd21409
    Location:54515529
    1B_cv_Nsp13-like; 1B domain of coronavirus SARS NSP13 helicase and related proteins
    cd21473
    Location:27543134
    cv_Nsp4_TM; coronavirus non-structural protein 4 (Nsp4) transmembrane domain
    cd21525
    Location:14721538
    SUD_C_SARS-CoV_Nsp3; C-terminal SARS-Unique Domain (SUD) of non-structural protein 3 (Nsp3) from Severe Acute Respiratory Syndrome coronavirus and related betacoronaviruses in the B lineage
    cd21560
    Location:35473836
    betaCoV-Nsp6; betacoronavirus non-structural protein 6
    cd21516
    Location:182818
    cv_beta_Nsp2_SARS-like; betacoronavirus non-structural protein 2 (Nsp2) similar to SARS-CoV Nsp2, and related proteins from betacoronaviruses in the B lineage
    cd21557
    Location:10341155
    Macro_X_Nsp3-like; X-domain of viral non-structural protein 3 and related macrodomains
    cd21562
    Location:12091334
    Macro_cv_SUD-N_Nsp3-like; SUD-N macrodomain of the SARS Unique Domain (SUD) of SARS-CoV non-structural protein 3 and related macrodomains
    cd21666
    Location:32443540
    betaCoV_Nsp5_Mpro; betacoronavirus non-structural protein 5, also called Main protease (Mpro)
    cd21591
    Location:43755301
    SARS-CoV-like_RdRp; Severe acute respiratory syndrome coronavirus RNA-dependent RNA polymerase, also known as non-structural protein 12, and similar proteins from betacoronaviruses in the B lineage: responsible for replication and transcription of the viral RNA genome
    cd21171
    Location:64306490
    NTD_alpha_beta_cv_Nsp15-like; N-terminal domain of alpha- and beta-coronavirus Nonstructural protein 15 (Nsp15), and related proteins
    cd21167
    Location:64946625
    M_alpha_beta_cv_Nsp15-like; middle domain of alpha- and beta-coronavirus Nonstructural protein 15 (Nsp15), and related proteins
    cd21161
    Location:66236773
    NendoU_cv_Nsp15-like; Nidoviral uridylate-specific endoribonuclease (NendoU) domain of coronavirus Nonstructural Protein 15 (Nsp15) and related proteins
    cd21659
    Location:59076427
    betaCoV_Nsp14; nonstructural protein 14 of betacoronavirus
    pfam06460
    Location:67777072
    NSP13; Coronavirus NSP13
    pfam08717
    Location:39204116
    nsp8; nsp8 replicase
    pfam12379
    Location:8811029
    DUF3655; Protein of unknown function (DUF3655)
    pfam16348
    Location:31463238
    Corona_NSP4_C; Coronavirus nonstructural protein 4 C-terminus
    cd21827
    Location:38373919
    betaCoV_Nsp7; betacoronavirus non-structural protein 7
    cd21872
    Location:42314361
    CoV_Nsp10; coronavirus non-structural protein 10
    cd21898
    Location:41184230
    betaCoV_Nsp9; betacoronavirus non-structural protein 9
    cd21796
    Location:13127
    SARS-CoV-like_Nsp1_N; N-terminal domain of non-structural protein 1 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21822
    Location:18901996
    SARS-CoV-like_Nsp3_NAB; nucleic acid binding domain of non-structural protein 3 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21814
    Location:20212136
    SARS-CoV-like_Nsp3_betaSM; betacoronavirus-specific marker of non-structural protein 3 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21732
    Location:15431845
    betaCoV_PLPro; betacoronavirus papain-like protease
    cd21722
    Location:55525891
    betaCoV_Nsp13-helicase; helicase domain of betacoronavirus non-structural protein 13
    cd21717
    Location:22092739
    TM_Y_SARS-CoV-like_Nsp3_C; C-terminus of non-structural protein 3, including transmembrane and Y domains, from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21689
    Location:54005447
    stalk_CoV_Nsp13-like; stalk domain of coronavirus Nsp13 helicase and related proteins
  2. NP_828860.2 nsp1

    Conserved Domains (1) summary
    cd21796
    Location:13127
    SARS-CoV-like_Nsp1_N; N-terminal domain of non-structural protein 1 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
  3. NP_828861.2 nsp2

    Conserved Domains (1) summary
    cd21516
    Location:2638
    cv_beta_Nsp2_SARS-like; betacoronavirus non-structural protein 2 (Nsp2) similar to SARS-CoV Nsp2, and related proteins from betacoronaviruses in the B lineage
  4. NP_828862.2 nsp3

    Conserved Domains (9) summary
    pfam11633
    Location:509651
    SUD-M; Single-stranded poly(A) binding domain
    cd21525
    Location:654720
    SUD_C_SARS-CoV_Nsp3; C-terminal SARS-Unique Domain (SUD) of non-structural protein 3 (Nsp3) from Severe Acute Respiratory Syndrome coronavirus and related betacoronaviruses in the B lineage
    cd21557
    Location:214337
    Macro_X_Nsp3-like; X-domain of viral non-structural protein 3 and related macrodomains
    cd21562
    Location:391516
    Macro_cv_SUD-N_Nsp3-like; SUD-N macrodomain of the SARS Unique Domain (SUD) of SARS-CoV non-structural protein 3 and related macrodomains
    pfam12379
    Location:63211
    DUF3655; Protein of unknown function (DUF3655)
    cd21822
    Location:10721178
    SARS-CoV-like_Nsp3_NAB; nucleic acid binding domain of non-structural protein 3 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21814
    Location:12031318
    SARS-CoV-like_Nsp3_betaSM; betacoronavirus-specific marker of non-structural protein 3 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21732
    Location:7251027
    betaCoV_PLPro; betacoronavirus papain-like protease
    cd21717
    Location:13911921
    TM_Y_SARS-CoV-like_Nsp3_C; C-terminus of non-structural protein 3, including transmembrane and Y domains, from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
  5. NP_904322.1 nsp4

    Conserved Domains (2) summary
    cd21473
    Location:14394
    cv_Nsp4_TM; coronavirus non-structural protein 4 (Nsp4) transmembrane domain
    pfam16348
    Location:406498
    Corona_NSP4_C; Coronavirus nonstructural protein 4 C-terminus
  6. NP_828863.1 3C-like protease

    Conserved Domains (1) summary
    cd21666
    Location:4300
    betaCoV_Nsp5_Mpro; betacoronavirus non-structural protein 5, also called Main protease (Mpro)
  7. NP_828864.1 nsp6

    Conserved Domains (1) summary
    cd21560
    Location:1290
    betaCoV-Nsp6; betacoronavirus non-structural protein 6
  8. NP_828865.1 nsp7

    Conserved Domains (1) summary
    cd21827
    Location:183
    betaCoV_Nsp7; betacoronavirus non-structural protein 7
  9. NP_828866.1 nsp8

    Conserved Domains (1) summary
    pfam08717
    Location:1197
    nsp8; nsp8 replicase
  10. NP_828867.1 nsp9

    Conserved Domains (1) summary
    cd21898
    Location:1113
    betaCoV_Nsp9; betacoronavirus non-structural protein 9
  11. NP_828868.1 nsp10

    Conserved Domains (1) summary
    cd21901
    Location:1131
    alpha_betaCoV_Nsp10; alphacoronavirus and betacoronavirus non-structural protein 14
  12. YP_009924301.1 RNA-dependent RNA polymerase

  13. NP_828870.1 helicase/NTPase

    Conserved Domains (3) summary
    COG1112
    Location:323592
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    cl21455
    Location:277407
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:443580
    UvrD_C_2; UvrD-like helicase C-terminal domain
  14. NP_828872.1 endoribonuclease

    Conserved Domains (1) summary
    pfam06471
    Location:168
    NSP11; NSP11
  15. NP_828873.2 2'-O-MTase

    Conserved Domains (1) summary
    pfam06460
    Location:2297
    NSP13; Coronavirus NSP13
  16. NP_828871.1 3' to 5' exonuclease

    Conserved Domains (1) summary
    pfam06471
    Location:3527
    NSP11; NSP11
  17. YP_009944365.1 ORF1a polyprotein [SARS coronavirus Tor2]

    Status: PROVISIONAL

    Conserved Domains (19) summary
    pfam11633
    Location:13271469
    SUD-M; Single-stranded poly(A) binding domain
    cd21473
    Location:27543134
    cv_Nsp4_TM; coronavirus non-structural protein 4 (Nsp4) transmembrane domain
    cd21525
    Location:14721538
    SUD_C_SARS-CoV_Nsp3; C-terminal SARS-Unique Domain (SUD) of non-structural protein 3 (Nsp3) from Severe Acute Respiratory Syndrome coronavirus and related betacoronaviruses in the B lineage
    cd21560
    Location:35473836
    betaCoV-Nsp6; betacoronavirus non-structural protein 6
    cd21516
    Location:182818
    cv_beta_Nsp2_SARS-like; betacoronavirus non-structural protein 2 (Nsp2) similar to SARS-CoV Nsp2, and related proteins from betacoronaviruses in the B lineage
    cd21557
    Location:10341155
    Macro_X_Nsp3-like; X-domain of viral non-structural protein 3 and related macrodomains
    cd21562
    Location:12091334
    Macro_cv_SUD-N_Nsp3-like; SUD-N macrodomain of the SARS Unique Domain (SUD) of SARS-CoV non-structural protein 3 and related macrodomains
    cd21666
    Location:32443540
    betaCoV_Nsp5_Mpro; betacoronavirus non-structural protein 5, also called Main protease (Mpro)
    pfam08717
    Location:39204116
    nsp8; nsp8 replicase
    pfam12379
    Location:8811029
    DUF3655; Protein of unknown function (DUF3655)
    pfam16348
    Location:31463238
    Corona_NSP4_C; Coronavirus nonstructural protein 4 C-terminus
    cd21827
    Location:38373919
    betaCoV_Nsp7; betacoronavirus non-structural protein 7
    cd21872
    Location:42314361
    CoV_Nsp10; coronavirus non-structural protein 10
    cd21898
    Location:41184230
    betaCoV_Nsp9; betacoronavirus non-structural protein 9
    cd21796
    Location:13127
    SARS-CoV-like_Nsp1_N; N-terminal domain of non-structural protein 1 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21822
    Location:18901996
    SARS-CoV-like_Nsp3_NAB; nucleic acid binding domain of non-structural protein 3 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21814
    Location:20212136
    SARS-CoV-like_Nsp3_betaSM; betacoronavirus-specific marker of non-structural protein 3 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21732
    Location:15431845
    betaCoV_PLPro; betacoronavirus papain-like protease
    cd21717
    Location:22092739
    TM_Y_SARS-CoV-like_Nsp3_C; C-terminus of non-structural protein 3, including transmembrane and Y domains, from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
  18. YP_009944366.1 nsp1

    Conserved Domains (1) summary
    cd21796
    Location:13127
    SARS-CoV-like_Nsp1_N; N-terminal domain of non-structural protein 1 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
  19. YP_009944367.1 nsp2

    Conserved Domains (1) summary
    cd21516
    Location:2638
    cv_beta_Nsp2_SARS-like; betacoronavirus non-structural protein 2 (Nsp2) similar to SARS-CoV Nsp2, and related proteins from betacoronaviruses in the B lineage
  20. YP_009944368.1 nsp3

    Conserved Domains (9) summary
    pfam11633
    Location:509651
    SUD-M; Single-stranded poly(A) binding domain
    cd21525
    Location:654720
    SUD_C_SARS-CoV_Nsp3; C-terminal SARS-Unique Domain (SUD) of non-structural protein 3 (Nsp3) from Severe Acute Respiratory Syndrome coronavirus and related betacoronaviruses in the B lineage
    cd21557
    Location:214337
    Macro_X_Nsp3-like; X-domain of viral non-structural protein 3 and related macrodomains
    cd21562
    Location:391516
    Macro_cv_SUD-N_Nsp3-like; SUD-N macrodomain of the SARS Unique Domain (SUD) of SARS-CoV non-structural protein 3 and related macrodomains
    pfam12379
    Location:63211
    DUF3655; Protein of unknown function (DUF3655)
    cd21822
    Location:10721178
    SARS-CoV-like_Nsp3_NAB; nucleic acid binding domain of non-structural protein 3 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21814
    Location:12031318
    SARS-CoV-like_Nsp3_betaSM; betacoronavirus-specific marker of non-structural protein 3 from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
    cd21732
    Location:7251027
    betaCoV_PLPro; betacoronavirus papain-like protease
    cd21717
    Location:13911921
    TM_Y_SARS-CoV-like_Nsp3_C; C-terminus of non-structural protein 3, including transmembrane and Y domains, from Severe acute respiratory syndrome-related coronavirus and betacoronavirus in the B lineage
  21. YP_009944369.1 nsp4

    Conserved Domains (2) summary
    cd21473
    Location:14394
    cv_Nsp4_TM; coronavirus non-structural protein 4 (Nsp4) transmembrane domain
    pfam16348
    Location:406498
    Corona_NSP4_C; Coronavirus nonstructural protein 4 C-terminus
  22. YP_009944370.1 3C-like protease

    Conserved Domains (1) summary
    cd21666
    Location:4300
    betaCoV_Nsp5_Mpro; betacoronavirus non-structural protein 5, also called Main protease (Mpro)
  23. YP_009944371.1 nsp6

    Conserved Domains (1) summary
    cd21560
    Location:1290
    betaCoV-Nsp6; betacoronavirus non-structural protein 6
  24. YP_009944372.1 nsp7

    Conserved Domains (1) summary
    cd21827
    Location:183
    betaCoV_Nsp7; betacoronavirus non-structural protein 7
  25. YP_009944373.1 nsp8

    Conserved Domains (1) summary
    pfam08717
    Location:1197
    nsp8; nsp8 replicase
  26. YP_009944374.1 nsp9

    Conserved Domains (1) summary
    cd21898
    Location:1113
    betaCoV_Nsp9; betacoronavirus non-structural protein 9
  27. YP_009944375.1 nsp10

    Conserved Domains (1) summary
    cd21901
    Location:1131
    alpha_betaCoV_Nsp10; alphacoronavirus and betacoronavirus non-structural protein 14
  28. YP_009944376.1 ndp11

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