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E6 E6 protein [ human papillomavirus 18 ]

Gene ID: 1489088, updated on 18-Aug-2023

Summary

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Gene symbol
E6
Gene description
E6 protein
Locus tag
HpV18gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
human papillomavirus 18
Lineage
Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus
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Genomic context

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Sequence:
NC_001357.1 (105..581)

NC_001357.1Genomic Context describing neighboring genes Neighboring gene E7 protein Neighboring gene E1 Neighboring gene E2 protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001357.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Acquisition of a phospho-acceptor site enhances HPV E6 PDZ-binding motif functional promiscuity. Sarabia-Vega V, et al. J Gen Virol, 2020 Sep. PMID 30810519
  2. The human papillomavirus (HPV) E6* proteins from high-risk, mucosal HPVs can direct degradation of cellular proteins in the absence of full-length E6 protein. Pim D, et al. J Virol, 2009 Oct. PMID 19640984, Free PMC Article
  3. E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/phosphatidylinositol 3-kinase (akt/PI3K) signaling pathway. Contreras-Paredes A, et al. Virology, 2009 Jan 5. PMID 19007961
  4. In GFP with high risk HPV-18E6 fusion protein expressed 293T and MCF-7 cells, the endogenous wild-type p53 could be transiently phosphorylated at multiple sites. Sun L, et al. J Exp Clin Cancer Res, 2008 Sep 8. PMID 18778462, Free PMC Article
  5. Differential splicing of E6 within human papillomavirus type 18 variants and functional consequences. De la Cruz-Hernández E, et al. J Gen Virol, 2005 Sep. PMID 16099904

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HPV-18E6 Inhibits Interactions between TANC2 and SNX27 in a PBM-Dependent Manner and Promotes Increased Cell Proliferation.
    Title: HPV-18E6 Inhibits Interactions between TANC2 and SNX27 in a PBM-Dependent Manner and Promotes Increased Cell Proliferation.
  2. Nanog, in Cooperation with AP1, Increases the Expression of E6/E7 Oncogenes from HPV Types 16/18.
    Title: Nanog, in Cooperation with AP1, Increases the Expression of E6/E7 Oncogenes from HPV Types 16/18.
  3. Inhibition of kinase IKKbeta suppresses cellular abnormalities induced by the human papillomavirus oncoprotein HPV 18E6.
    Title: Inhibition of kinase IKKβ suppresses cellular abnormalities induced by the human papillomavirus oncoprotein HPV 18E6.
  4. Acquisition of a phospho-acceptor site enhances HPV E6 PDZ-binding motif functional promiscuity.
    Title: Acquisition of a phospho-acceptor site enhances HPV E6 PDZ-binding motif functional promiscuity.
  5. Alternative splicing of E6E7 transcripts showed E6*I as the most frequent isoform for both viral types, followed by E6*II and E6/E7 (unspliced) transcripts in HPV16+, and by E6/E7 in HPV18+ tumors.
    Title: Characterization of HPV integration, viral gene expression and E6E7 alternative transcripts by RNA-Seq: A descriptive study in invasive cervical cancer.
  6. There is a type-dependent association between HPV16/18 DNA load and E6 protein; our study furthers the understanding of the natural history of cervical cancer.
    Title: The association between human papillomavirus 16, 18 DNA load and E6 protein expression in cervical intraepithelial neoplasia and cancer.
  7. These data suggest that HPV18 modulates its production ratio of E6 and E7 proteins by alternative selection of the two mapped branch sites for the E6*I splicing, which could be beneficial in its productive or oncogenic infection according to the host cell environment.
    Title: HPV18 Utilizes Two Alternative Branch Sites for E6*I Splicing to Produce E7 Protein.
  8. E6 association with cellular PDZ proteins promotes the nuclear localization of YAP1.
    Title: Human Papillomavirus E6 interaction with cellular PDZ domain proteins modulates YAP nuclear localization.
  9. Findings indicate O-linked N-acetylglucosamine transferase (OGT) as a cellular factor involved in human papillomaviruses type 16/18 E6 and E7 expressions and cervical cancer tumorigenesis, suggesting that targeting OGT in cervical cancer may have potential therapeutic benefit.
    Title: O-linked N-acetylglucosamine transferase promotes cervical cancer tumorigenesis through human papillomaviruses E6 and E7 oncogenes.
  10. The viral oncoprotein E6 interaction with SNX27 can alter the recycling of cargo molecules, one consequence of which is modulation of nutrient availability in HPV transformed tumour cells.
    Title: Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways.
Submit: New GeneRIF Correction See all GeneRIFs (55)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
E6 protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001357.1 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_040310.1 E6 protein [human papillomavirus 18]

    See identical proteins and their annotated locations for NP_040310.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P06463
    UniProtKB/TrEMBL
    A0A059VJI9, A0A088S6B3, A0A0K2GNF2, A0A0K2GNI9, A0A0K2GNP7, A0A0K2GNP8, A0A0K2GNQ5, A0A0K2GNT4, A0A0K2GNU9, A0A0K2GP56, A0A0K2GPE4, A0A0K2GPG3, A0A0U3JLN9, A0A0U3JRD5, A0A159DQY0, A0A1X9ZDQ9, A0A1X9ZDU1, A0A4D6Q6Z7, A0A6F8Z7X3, A0A7D5HQZ9, A0A7D5IFD8, A0A7G8YWE6, A0A7G8YWE8, D3ITV5, Q76Z97, Q9QNP8
    Conserved Domains (1) summary
    cl27673
    Location:14 → 141
    E6; Early Protein (E6)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06463.1

Gene LinkOut

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