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Gtf2i general transcription factor II I [ Mus musculus (house mouse) ]

Gene ID: 14886, updated on 12-May-2024

Summary

Official Symbol
Gtf2iprovided by MGI
Official Full Name
general transcription factor II Iprovided by MGI
Primary source
MGI:MGI:1202722
See related
Ensembl:ENSMUSG00000060261 AllianceGenome:MGI:1202722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spin; Diws1t; TFII-I; WBSCR6; BAP-135; GtfII-I; 6030441I21Rik
Summary
Enables mitogen-activated protein kinase binding activity. Acts upstream of or within transition between slow and fast fiber. Located in cell projection; neuronal cell body; and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; respiratory system; and tooth. Used to study Williams-Beuren syndrome. Orthologous to human GTF2I (general transcription factor IIi). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 36.6), limb E14.5 (RPKM 32.6) and 28 other tissues See more
Orthologs
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Genomic context

See Gtf2i in Genome Data Viewer
Location:
5 G2; 5 74.48 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134266686..134346571, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134237832..134317678, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E105 Neighboring gene STARR-positive B cell enhancer ABC_E4791 Neighboring gene GTF2I repeat domain containing 2 Neighboring gene predicted gene, 57734 Neighboring gene STARR-positive B cell enhancer mm9_chr5:134712733-134713034 Neighboring gene neutrophil cytosolic factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E8084 Neighboring gene STARR-seq mESC enhancer starr_14530 Neighboring gene STARR-seq mESC enhancer starr_14534 Neighboring gene microRNA 3965 Neighboring gene predicted gene, 46925

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • 6030441I21Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
general transcription factor II-I
Names
BTK-associated protein 135
Bruton tyrosine kinase-associated protein 135
SRF-Phox1-interacting protein
Williams-Beuren syndrome chromosomal region 6 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080746.2NP_001074215.1  general transcription factor II-I isoform 1

    See identical proteins and their annotated locations for NP_001074215.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as Gamma).
    Source sequence(s)
    AC093346, BC053044, CB250008
    Consensus CDS
    CCDS39301.1
    UniProtKB/Swiss-Prot
    O54700, O55030, O55031, Q8VHD1, Q8VHD2, Q8VHD3, Q8VHD4, Q9CSB5, Q9D9K9, Q9ESZ8
    UniProtKB/TrEMBL
    G3UYD0
    Related
    ENSMUSP00000049625.8, ENSMUST00000059042.15
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  2. NM_001080747.2NP_001074216.1  general transcription factor II-I isoform 3

    See identical proteins and their annotated locations for NP_001074216.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (3, also known as Alpha) is shorter than isoform 1.
    Source sequence(s)
    AC093346, BC053044, CB250008
    Consensus CDS
    CCDS39300.1
    UniProtKB/TrEMBL
    G3UYD0
    Related
    ENSMUSP00000080714.4, ENSMUST00000082057.10
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  3. NM_001080748.2NP_001074217.1  general transcription factor II-I isoform 4

    See identical proteins and their annotated locations for NP_001074217.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' coding region compared to variant 1. The encoded isoform (4, also known as Delta or Short) is shorter than isoform 1.
    Source sequence(s)
    AC093346, BC053044, CB250008
    Consensus CDS
    CCDS57386.1
    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  4. NM_001080749.2NP_001074218.1  general transcription factor II-I isoform 5

    See identical proteins and their annotated locations for NP_001074218.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC093346, AK147201, CB250008, MG954273
    Consensus CDS
    CCDS57387.1
    UniProtKB/TrEMBL
    G3UYD0, Q3UHU8
    Related
    ENSMUSP00000133444.2, ENSMUST00000173341.9
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  5. NM_001359062.1NP_001345991.1  general transcription factor II-I isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AC093346, CB250008, MG954273
    Consensus CDS
    CCDS39301.1
    UniProtKB/Swiss-Prot
    O54700, O55030, O55031, Q8VHD1, Q8VHD2, Q8VHD3, Q8VHD4, Q9CSB5, Q9D9K9, Q9ESZ8
    UniProtKB/TrEMBL
    G3UYD0
    Related
    ENSMUSP00000133566.2, ENSMUST00000174155.8
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  6. NM_001359063.1NP_001345992.1  general transcription factor II-I isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 2 and 8, encodes isoform 2.
    Source sequence(s)
    AC093346, CB250008, MG954273
    Consensus CDS
    CCDS39299.1
    UniProtKB/TrEMBL
    G3UYD0
    Related
    ENSMUSP00000134440.2, ENSMUST00000174354.8
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  7. NM_001359064.1NP_001345993.1  general transcription factor II-I isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 2 and 7, encodes isoform 2.
    Source sequence(s)
    AC093346
    Consensus CDS
    CCDS39299.1
    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  8. NM_001359065.1NP_001345994.1  general transcription factor II-I isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variant 3, encodes isoform 3.
    Source sequence(s)
    AC093346, CB250008, MG954273
    Consensus CDS
    CCDS39300.1
    UniProtKB/TrEMBL
    G3UYD0
    Related
    ENSMUSP00000133740.2, ENSMUST00000174772.8
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  9. NM_001359066.1NP_001345995.1  general transcription factor II-I isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 4 and 11, encodes isoform 4.
    Source sequence(s)
    AC093346, CB250008, MG954273
    Consensus CDS
    CCDS57386.1
    UniProtKB/TrEMBL
    G3UYD0
    Related
    ENSMUSP00000133489.2, ENSMUST00000174513.8
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  10. NM_001359067.1NP_001345996.1  general transcription factor II-I isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variant 4 and 10, encodes isoform 4.
    Source sequence(s)
    AC093346
    Consensus CDS
    CCDS57386.1
    UniProtKB/TrEMBL
    G3UYD0
    Related
    ENSMUSP00000133969.2, ENSMUST00000173888.8
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  11. NM_010365.4NP_034495.2  general transcription factor II-I isoform 2

    See identical proteins and their annotated locations for NP_034495.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2, also known as Beta or Long) is shorter than isoform 1.
    Source sequence(s)
    AC093346, BC053044, CB250008
    Consensus CDS
    CCDS39299.1
    UniProtKB/TrEMBL
    G3UYD0
    Related
    ENSMUSP00000106892.5, ENSMUST00000111261.12
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    134266686..134346571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254157.2XP_030110017.1  general transcription factor II-I isoform X15

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  2. XM_006504386.2XP_006504449.1  general transcription factor II-I isoform X4

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  3. XM_006504389.2XP_006504452.1  general transcription factor II-I isoform X6

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  4. XM_006504384.2XP_006504447.1  general transcription factor II-I isoform X1

    See identical proteins and their annotated locations for XP_006504447.1

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  5. XM_006504385.2XP_006504448.1  general transcription factor II-I isoform X3

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  6. XM_030254165.2XP_030110025.1  general transcription factor II-I isoform X23

    UniProtKB/TrEMBL
    G3UYD0
    Related
    ENSMUSP00000134035.2, ENSMUST00000172715.8
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  7. XM_030254163.2XP_030110023.1  general transcription factor II-I isoform X22

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  8. XM_036164817.1XP_036020710.1  general transcription factor II-I isoform X19

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  9. XM_036164818.1XP_036020711.1  general transcription factor II-I isoform X20

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  10. XM_030254159.2XP_030110019.1  general transcription factor II-I isoform X16

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  11. XM_036164815.1XP_036020708.1  general transcription factor II-I isoform X18

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  12. XM_030254161.2XP_030110021.1  general transcription factor II-I isoform X21

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  13. XM_036164813.1XP_036020706.1  general transcription factor II-I isoform X12

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  14. XM_030254148.2XP_030110008.1  general transcription factor II-I isoform X7

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  15. XM_036164810.1XP_036020703.1  general transcription factor II-I isoform X9

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  16. XM_030254155.2XP_030110015.1  general transcription factor II-I isoform X10

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  17. XM_036164806.1XP_036020699.1  general transcription factor II-I isoform X5

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  18. XM_030254147.2XP_030110007.1  general transcription factor II-I isoform X2

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  19. XM_030254156.2XP_030110016.1  general transcription factor II-I isoform X13

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  20. XM_006504391.2XP_006504454.1  general transcription factor II-I isoform X14

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  21. XM_030254153.2XP_030110013.1  general transcription factor II-I isoform X8

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  22. XM_017320677.2XP_017176166.1  general transcription factor II-I isoform X11

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  23. XM_030254162.2XP_030110022.1  general transcription factor II-I isoform X21

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  24. XM_036164803.1XP_036020696.1  general transcription factor II-I isoform X2

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  25. XM_030254145.2XP_030110005.1  general transcription factor II-I isoform X1

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  26. XM_030254144.2XP_030110004.1  general transcription factor II-I isoform X1

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  27. XM_036164808.1XP_036020701.1  general transcription factor II-I isoform X7

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  28. XM_036164804.1XP_036020697.1  general transcription factor II-I isoform X2

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  29. XM_030254154.2XP_030110014.1  general transcription factor II-I isoform X8

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  30. XM_030254146.2XP_030110006.1  general transcription factor II-I isoform X1

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  31. XM_036164802.1XP_036020695.1  general transcription factor II-I isoform X2

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  32. XM_036164809.1XP_036020702.1  general transcription factor II-I isoform X8

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  33. XM_030254140.2XP_030110000.1  general transcription factor II-I isoform X1

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  34. XM_030254141.2XP_030110001.1  general transcription factor II-I isoform X1

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  35. XM_030254164.2XP_030110024.1  general transcription factor II-I isoform X22

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  36. XM_030254158.2XP_030110018.1  general transcription factor II-I isoform X15

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  37. XM_036164805.1XP_036020698.1  general transcription factor II-I isoform X3

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  38. XM_030254151.2XP_030110011.1  general transcription factor II-I isoform X7

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  39. XM_036164814.1XP_036020707.1  general transcription factor II-I isoform X12

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  40. XM_036164807.1XP_036020700.1  general transcription factor II-I isoform X6

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  41. XM_036164819.1XP_036020712.1  general transcription factor II-I isoform X20

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  42. XM_036164816.1XP_036020709.1  general transcription factor II-I isoform X18

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  43. XM_017320681.3XP_017176170.1  general transcription factor II-I isoform X17

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112184
    GTF2I; GTF2I-like repeat
  44. XM_036164811.1XP_036020704.1  general transcription factor II-I isoform X9

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat
  45. XM_036164812.1XP_036020705.1  general transcription factor II-I isoform X9

    UniProtKB/TrEMBL
    G3UYD0
    Conserved Domains (1) summary
    pfam02946
    Location:112186
    GTF2I; GTF2I-like repeat