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Gstz1 glutathione transferase zeta 1 (maleylacetoacetate isomerase) [ Mus musculus (house mouse) ]

Gene ID: 14874, updated on 2-Nov-2024

Summary

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Official Symbol
Gstz1provided by MGI
Official Full Name
glutathione transferase zeta 1 (maleylacetoacetate isomerase)provided by MGI
Primary source
MGI:MGI:1341859
See related
Ensembl:ENSMUSG00000021033 AllianceGenome:MGI:1341859
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MAAI; GSTZ1-1
Summary
Predicted to enable glutathione transferase activity; maleylacetoacetate isomerase activity; and protein homodimerization activity. Predicted to be involved in L-phenylalanine catabolic process and glutathione metabolic process. Predicted to act upstream of or within tyrosine catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human GSTZ1 (glutathione S-transferase zeta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver adult (RPKM 145.2), subcutaneous fat pad adult (RPKM 143.0) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Gstz1 in Genome Data Viewer
Location:
12 D2; 12 41.34 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (87192102..87211497)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (87147161..87164723)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 63c Neighboring gene crumbs homolog 1 pseudogene Neighboring gene neuroglobin Neighboring gene protein-O-mannosyltransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E10770 Neighboring gene STARR-positive B cell enhancer ABC_E10771 Neighboring gene predicted gene 6566 Neighboring gene transmembrane p24 trafficking protein 8 Neighboring gene STARR-positive B cell enhancer ABC_E9041 Neighboring gene sterile alpha motif domain containing 15 Neighboring gene NADP+ dependent oxidoreductase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Signaling metabolite succinylacetone activates HIF-1α and promotes angiogenesis in GSTZ1-deficient hepatocellular carcinoma. Luo H, et al. JCI Insight, 2023 Oct 31. PMID 37906252, Free PMC Article
  2. Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases. Lim CE, et al. Am J Pathol, 2004 Aug. PMID 15277241, Free PMC Article
  3. Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents. Ammini CV, et al. Biochem Pharmacol, 2003 Nov 15. PMID 14599561
  4. Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a glutathione-dependent nonenzymatic bypass in tyrosine catabolism. Fernández-Cañón JM, et al. Mol Cell Biol, 2002 Jul. PMID 12052898, Free PMC Article
  5. Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways. Blackburn AC, et al. Mol Pharmacol, 2006 Feb. PMID 16278372

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a glutathione-dependent nonenzymatic bypass in tyrosine catabolism
    Title: Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a glutathione-dependent nonenzymatic bypass in tyrosine catabolism.
  2. GSTZ1-1 deficiency may alter the metabolism of some drugs and xenobiotics.
    Title: Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways.
  3. glutathione S-transferase zeta/maleylacetoacetate isomerase is induced by C/EBPalpha and dependent on PPAR gamma
    Title: C/EBPalpha-dependent induction of glutathione S-transferase zeta/maleylacetoacetate isomerase (GSTzeta/MAAI) expression during the differentiation of mouse fibroblasts into adipocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables maleylacetoacetate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables maleylacetoacetate isomerase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-phenylalanine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-phenylalanine catabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tyrosine catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
maleylacetoacetate isomerase
Names
glutathione S-transferase zeta 1
NP_001239484.1
NP_001239485.1
NP_001351235.1
NP_001351236.1
NP_034493.1
XP_006515537.1
XP_006515538.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252555.1 → NP_001239484.1  maleylacetoacetate isomerase isoform 2

    See identical proteins and their annotated locations for NP_001239484.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AA244513, AB041613, AK075927
    Consensus CDS
    CCDS88379.1
    UniProtKB/TrEMBL
    A0A1Y7VNC1, Q9JJA0
    Related
    ENSMUSP00000152343.2, ENSMUST00000222885.2
    Conserved Domains (1) summary
    TIGR01262
    Location:1 → 156
    maiA; maleylacetoacetate isomerase

  2. NM_001252556.1 → NP_001239485.1  maleylacetoacetate isomerase isoform 2

    See identical proteins and their annotated locations for NP_001239485.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AA244513, AK075927, BF722376, BY072664
    Consensus CDS
    CCDS88379.1
    UniProtKB/TrEMBL
    A0A1Y7VNC1, Q9JJA0
    Related
    ENSMUSP00000152321.2, ENSMUST00000220574.2
    Conserved Domains (1) summary
    TIGR01262
    Location:1 → 156
    maiA; maleylacetoacetate isomerase

  3. NM_001364306.1 → NP_001351235.1  maleylacetoacetate isomerase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132609
    Consensus CDS
    CCDS88378.1
    UniProtKB/TrEMBL
    A0A1Y7VJZ2
    Related
    ENSMUSP00000152707.2, ENSMUST00000222222.2
    Conserved Domains (1) summary
    TIGR01262
    Location:6 → 210
    maiA; maleylacetoacetate isomerase

  4. NM_001364307.1 → NP_001351236.1  maleylacetoacetate isomerase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132609
    Consensus CDS
    CCDS88379.1
    UniProtKB/TrEMBL
    A0A1Y7VNC1, Q9JJA0
    Conserved Domains (1) summary
    TIGR01262
    Location:1 → 156
    maiA; maleylacetoacetate isomerase

  5. NM_010363.4 → NP_034493.1  maleylacetoacetate isomerase isoform 1

    See identical proteins and their annotated locations for NP_034493.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA244513, AK075927, BY072664
    Consensus CDS
    CCDS26071.1
    UniProtKB/Swiss-Prot
    Q9WVL0
    Related
    ENSMUSP00000053540.9, ENSMUST00000063117.10
    Conserved Domains (3) summary
    cd03191
    Location:93 → 207
    GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
    cd03042
    Location:6 → 80
    GST_N_Zeta; GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    TIGR01262
    Location:7 → 211
    maiA; maleylacetoacetate isomerase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    87192102..87211497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515474.4 → XP_006515537.1  maleylacetoacetate isomerase isoform X1

    See identical proteins and their annotated locations for XP_006515537.1

    UniProtKB/TrEMBL
    A0A1Y7VNC1, Q9JJA0
    Conserved Domains (1) summary
    TIGR01262
    Location:1 → 156
    maiA; maleylacetoacetate isomerase

  2. XM_006515475.2 → XP_006515538.1  maleylacetoacetate isomerase isoform X1

    See identical proteins and their annotated locations for XP_006515538.1

    UniProtKB/TrEMBL
    A0A1Y7VNC1, Q9JJA0
    Conserved Domains (1) summary
    TIGR01262
    Location:1 → 156
    maiA; maleylacetoacetate isomerase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVL0.1 GenPept UniProtKB/Swiss-Prot:Q9WVL0

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