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Gstm1 glutathione S-transferase, mu 1 [ Mus musculus (house mouse) ]

Gene ID: 14862, updated on 12-May-2024

Summary

Official Symbol
Gstm1provided by MGI
Official Full Name
glutathione S-transferase, mu 1provided by MGI
Primary source
MGI:MGI:95860
See related
Ensembl:ENSMUSG00000058135 AllianceGenome:MGI:95860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gstb1; Gstb-1
Summary
Enables identical protein binding activity. Acts upstream of or within cellular response to xenobiotic stimulus. Located in myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver; and sensory organ. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human GSTM1 (glutathione S-transferase mu 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 2975.4), liver adult (RPKM 1111.2) and 10 other tissues See more
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Genomic context

See Gstm1 in Genome Data Viewer
Location:
3 F2.3; 3 46.83 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107919566..107925289, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108012250..108017973, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 12497 Neighboring gene glutathione S-transferase, mu 2 Neighboring gene STARR-seq mESC enhancer starr_08676 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:107820964-107821073 Neighboring gene predicted gene 12502 Neighboring gene predicted gene, 36498 Neighboring gene glutathione S-transferase, mu 4 Neighboring gene predicted gene, 25592

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables glutathione binding ISO
Inferred from Sequence Orthology
more info
 
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nickel cation binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables steroid binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in xenobiotic catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutathione S-transferase Mu 1
Names
GST 1-1
GST class-mu 1
glutathione S-transferase GT8.7
pmGT10
NP_001361607.1
NP_034488.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374678.1NP_001361607.1  glutathione S-transferase Mu 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC079042, AL671877
    Consensus CDS
    CCDS89677.1
    UniProtKB/TrEMBL
    A2AE89
    Related
    ENSMUSP00000118874.3, ENSMUST00000126593.3
    Conserved Domains (2) summary
    cd03209
    Location:92238
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cd03075
    Location:384
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
  2. NM_010358.5NP_034488.1  glutathione S-transferase Mu 1 isoform 2

    See identical proteins and their annotated locations for NP_034488.1

    Status: VALIDATED

    Source sequence(s)
    AI841190, AL671877, BC046758
    Consensus CDS
    CCDS17747.1
    UniProtKB/Swiss-Prot
    A2AE90, P10649, Q58ET5
    Related
    ENSMUSP00000004140.5, ENSMUST00000004140.11
    Conserved Domains (2) summary
    cd03209
    Location:92212
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cd03075
    Location:384
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    107919566..107925289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)