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UBE2U ubiquitin conjugating enzyme E2 U [ Homo sapiens (human) ]

Gene ID: 148581, updated on 11-Jun-2021

Summary

Official Symbol
UBE2Uprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Uprovided by HGNC
Primary source
HGNC:HGNC:28559
See related
Ensembl:ENSG00000177414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward testis (RPKM 8.1) See more
Orthologs
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Genomic context

See UBE2U in Genome Data Viewer
Location:
1p31.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (64202802..64267381)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (64669306..64733051)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene receptor tyrosine kinase like orphan receptor 1 Neighboring gene ROR1 antisense RNA 1 Neighboring gene uncharacterized LOC105378773 Neighboring gene uncharacterized LOC105378774 Neighboring gene RNA, U7 small nuclear 62 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC35130

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of HULC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 U
Names
E2 ubiquitin-conjugating enzyme U
testicular tissue protein Li 216
ubiquitin carrier protein U
ubiquitin conjugating enzyme E2 U (putative)
ubiquitin conjugating enzyme E2U (putative)
ubiquitin-protein ligase U
NP_001353161.1
NP_001353162.1
NP_001353163.1
NP_001353164.1
NP_689702.1
XP_006710442.1
XP_011539066.1
XP_016855868.1
XP_016855869.1
XP_016855870.1
XP_016855871.1
XP_016855872.1
XP_016855873.1
XP_016855874.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366232.2NP_001353161.1  ubiquitin-conjugating enzyme E2 U isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL161916, AL445205
    Related
    ENSP00000360117.5, ENST00000371077.10
    Conserved Domains (1) summary
    cd00195
    Location:8147
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. NM_001366233.2NP_001353162.1  ubiquitin-conjugating enzyme E2 U isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL161916, AL445205
    Conserved Domains (1) summary
    cd00195
    Location:8146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  3. NM_001366234.2NP_001353163.1  ubiquitin-conjugating enzyme E2 U isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL161916, AL445205
    Conserved Domains (1) summary
    cd00195
    Location:8147
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  4. NM_001366235.1NP_001353164.1  ubiquitin-conjugating enzyme E2 U isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL161916, AL445205
    Conserved Domains (1) summary
    cd00195
    Location:8147
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  5. NM_152489.3NP_689702.1  ubiquitin-conjugating enzyme E2 U isoform 4

    See identical proteins and their annotated locations for NP_689702.1

    Status: VALIDATED

    Source sequence(s)
    AL161916, BC029895, BG773201, BX112562
    Consensus CDS
    CCDS627.1
    UniProtKB/Swiss-Prot
    Q5VVX9
    UniProtKB/TrEMBL
    A0A140VJY9
    Related
    ENSP00000360116.3, ENST00000371076.7
    Conserved Domains (1) summary
    cd00195
    Location:8147
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RNA

  1. NR_158768.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL161916, AL445205
  2. NR_158769.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL161916, AL445205

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    64202802..64267381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540764.2XP_011539066.1  ubiquitin-conjugating enzyme E2 U isoform X1

    See identical proteins and their annotated locations for XP_011539066.1

    Conserved Domains (1) summary
    cd00195
    Location:8147
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. XM_006710379.3XP_006710442.1  ubiquitin-conjugating enzyme E2 U isoform X3

    Conserved Domains (1) summary
    cd00195
    Location:1115
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  3. XM_017000380.1XP_016855869.1  ubiquitin-conjugating enzyme E2 U isoform X5

  4. XM_017000383.1XP_016855872.1  ubiquitin-conjugating enzyme E2 U isoform X6

  5. XM_017000379.1XP_016855868.1  ubiquitin-conjugating enzyme E2 U isoform X5

  6. XM_017000385.1XP_016855874.1  ubiquitin-conjugating enzyme E2 U isoform X7

    Related
    ENSP00000476556.1, ENST00000608956.1
  7. XM_017000381.1XP_016855870.1  ubiquitin-conjugating enzyme E2 U isoform X5

  8. XM_017000384.1XP_016855873.1  ubiquitin-conjugating enzyme E2 U isoform X6

    Related
    ENSP00000477356.1, ENST00000608020.5
  9. XM_017000382.1XP_016855871.1  ubiquitin-conjugating enzyme E2 U isoform X5

RNA

  1. XR_002959500.1 RNA Sequence

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