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Cxcl1 chemokine (C-X-C motif) ligand 1 [ Mus musculus (house mouse) ]

Gene ID: 14825, updated on 13-Jan-2020

Summary

Official Symbol
Cxcl1provided by MGI
Official Full Name
chemokine (C-X-C motif) ligand 1provided by MGI
Primary source
MGI:MGI:108068
See related
Ensembl:ENSMUSG00000029380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KC; Fsp; N51; gro; Gro1; Mgsa; Scyb1
Summary
This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013]
Expression
Broad expression in ovary adult (RPKM 2.9), placenta adult (RPKM 2.3) and 22 other tissues See more

Genomic context

See Cxcl1 in Genome Data Viewer
Location:
5 E1; 5 44.78 cM
Exon count:
4
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (90891245..90893121)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (91320271..91322147)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene chemokine (C-X-C motif) ligand 3 Neighboring gene chemokine (C-X-C motif) ligand 15 Neighboring gene chemokine (C-X-C motif) ligand 2 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like Neighboring gene predicted gene, 52819

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine activity ISO
Inferred from Sequence Orthology
more info
 
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
defense response IEA
Inferred from Electronic Annotation
more info
 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
killing of cells of other organism ISO
Inferred from Sequence Orthology
more info
 
leukocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neutrophil mediated killing of fungus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of superoxide anion generation IDA
Inferred from Direct Assay
more info
PubMed 
response to molecule of bacterial origin ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
growth-regulated alpha protein
Names
C-X-C motif chemokine 1
GRO1 oncogene
KC/GR)-alpha
KC/GRO-alpha
alpha-chemokine
platelet-derived growth factor-inducible protein KC
secretory protein N51

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008176.3NP_032202.1  growth-regulated alpha protein precursor

    See identical proteins and their annotated locations for NP_032202.1

    Status: REVIEWED

    Source sequence(s)
    BQ031102, BY335927
    Consensus CDS
    CCDS39143.1
    UniProtKB/Swiss-Prot
    P12850
    UniProtKB/TrEMBL
    A2RTH0
    Related
    ENSMUSP00000031327.8, ENSMUST00000031327.8
    Conserved Domains (1) summary
    cd00273
    Location:3092
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p6 C57BL/6J

    Range
    90891245..90893121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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