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Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) [ Mus musculus (house mouse) ]

Gene ID: 14812, updated on 9-Sep-2018

Summary

Official Symbol
Grin2bprovided by MGI
Official Full Name
glutamate receptor, ionotropic, NMDA2B (epsilon 2)provided by MGI
Primary source
MGI:MGI:95821
See related
Ensembl:ENSMUSG00000030209 Vega:OTTMUSG00000016356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NR2B; GluN2B; Nmdar2b; AW490526; GluRepsilon2
Expression
Biased expression in cortex adult (RPKM 5.7), frontal lobe adult (RPKM 5.7) and 5 other tissues See more
Orthologs

Genomic context

See Grin2b in Genome Data Viewer
Location:
6 G1; 6 66.38 cM
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (135729795..136173822, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (135679813..136123529, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930425L21 gene Neighboring gene predicted gene, 38911 Neighboring gene predicted gene 14329 Neighboring gene predicted gene, 26653 Neighboring gene tubulin, beta 3 class III, pseudogene 1 Neighboring gene zinc finger protein 707 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
D2 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
NMDA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NMDA glutamate receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
NMDA glutamate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
NMDA glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cation channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
extracellularly glutamate-gated ion channel activity ISO
Inferred from Sequence Orthology
more info
 
glutamate binding ISO
Inferred from Sequence Orthology
more info
 
glutamate-gated calcium ion channel activity ISO
Inferred from Sequence Orthology
more info
 
glycine binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-1 receptor binding ISO
Inferred from Sequence Orthology
more info
 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter binding ISO
Inferred from Sequence Orthology
more info
 
neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
NMDA selective glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
action potential ISO
Inferred from Sequence Orthology
more info
 
associative learning ISO
Inferred from Sequence Orthology
more info
 
behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral fear response ISO
Inferred from Sequence Orthology
more info
 
behavioral response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion transmembrane import into cytosol ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
cation transport IGI
Inferred from Genetic Interaction
more info
PubMed 
chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
detection of mechanical stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
excitatory postsynaptic potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
excitatory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
PubMed 
excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
learning IDA
Inferred from Direct Assay
more info
PubMed 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning or memory ISO
Inferred from Sequence Orthology
more info
 
learning or memory TAS
Traceable Author Statement
more info
PubMed 
long-term synaptic potentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-term synaptic potentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
memory IDA
Inferred from Direct Assay
more info
PubMed 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
memory ISO
Inferred from Sequence Orthology
more info
 
negative regulation of dendritic spine maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glutamate secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron death IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
protein heterotetramerization ISO
Inferred from Sequence Orthology
more info
 
receptor clustering ISO
Inferred from Sequence Orthology
more info
 
regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
regulation of neuronal synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
regulation of postsynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein kinase A signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ethanol ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
response to organonitrogen compound ISO
Inferred from Sequence Orthology
more info
 
rhythmic process ISO
Inferred from Sequence Orthology
more info
 
sensitization ISO
Inferred from Sequence Orthology
more info
 
sensory organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
startle response IGI
Inferred from Genetic Interaction
more info
PubMed 
startle response IMP
Inferred from Mutant Phenotype
more info
PubMed 
suckling behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
NMDA selective glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NMDA selective glutamate receptor complex IPI
Inferred from Physical Interaction
more info
PubMed 
NMDA selective glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
NMDA selective glutamate receptor complex TAS
Traceable Author Statement
more info
PubMed 
Z disc ISO
Inferred from Sequence Orthology
more info
 
apical dendrite ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
hippocampal mossy fiber to CA3 synapse ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane bounded cell projection part TAS
Traceable Author Statement
more info
PubMed 
postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synapse ISO
Inferred from Sequence Orthology
more info
 
synaptic cleft ISO
Inferred from Sequence Orthology
more info
 
synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamate receptor ionotropic, NMDA 2B
Names
N-methyl D-aspartate receptor subtype 2B
glutamate [NMDA] receptor subunit epsilon-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363750.1NP_001350679.1  glutamate receptor ionotropic, NMDA 2B precursor

    Status: VALIDATED

    Source sequence(s)
    AC124500, AC124590, AC132119, AC161364
    Conserved Domains (3) summary
    cd06378
    Location:33393
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  2. NM_008171.4NP_032197.3  glutamate receptor ionotropic, NMDA 2B precursor

    See identical proteins and their annotated locations for NP_032197.3

    Status: VALIDATED

    Source sequence(s)
    AC124500, AC124590, AC132119, AC161364
    Consensus CDS
    CCDS20648.1
    UniProtKB/Swiss-Prot
    Q01097
    UniProtKB/TrEMBL
    G3X9V4
    Related
    ENSMUSP00000107536.1, ENSMUST00000111905.7
    Conserved Domains (3) summary
    cd06378
    Location:33393
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    135729795..136173822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505575.3XP_006505638.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    See identical proteins and their annotated locations for XP_006505638.1

    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd06378
    Location:33393
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  2. XM_011241220.2XP_011239522.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    See identical proteins and their annotated locations for XP_011239522.1

    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd06378
    Location:33393
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  3. XM_011241221.2XP_011239523.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    See identical proteins and their annotated locations for XP_011239523.1

    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd06378
    Location:33393
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  4. XM_017321396.1XP_017176885.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd06378
    Location:33393
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  5. XM_006505574.3XP_006505637.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    See identical proteins and their annotated locations for XP_006505637.1

    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd06378
    Location:33393
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  6. XM_006505573.3XP_006505636.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    See identical proteins and their annotated locations for XP_006505636.1

    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd06378
    Location:33393
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
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