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Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) [ Mus musculus (house mouse) ]

Gene ID: 14812, updated on 8-Feb-2024

Summary

Official Symbol
Grin2bprovided by MGI
Official Full Name
glutamate receptor, ionotropic, NMDA2B (epsilon 2)provided by MGI
Primary source
MGI:MGI:95821
See related
Ensembl:ENSMUSG00000030209 AllianceGenome:MGI:95821
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NR2B; GluN2B; Nmdar2b; GluRepsilon2
Summary
Enables NMDA glutamate receptor activity; calcium channel activity; and neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential. Involved in negative regulation of dendritic spine maintenance and positive regulation of neuron death. Acts upstream of or within several processes, including behavioral fear response; detection of mechanical stimulus involved in sensory perception of pain; and learning or memory. Located in several cellular components, including cytoplasmic vesicle; lysosome; and synaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Is expressed in several structures, including adipose tissue; central nervous system; eye; gut; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant non-syndromic intellectual disability 6; bipolar disorder; developmental and epileptic encephalopathy 27; and neurodegenerative disease (multiple). Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 5.7), frontal lobe adult (RPKM 5.7) and 5 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See Grin2b in Genome Data Viewer
Location:
6 G1; 6 66.38 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (135690219..136150658, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (135713221..136173615, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930425L21 gene Neighboring gene STARR-seq mESC enhancer starr_17574 Neighboring gene predicted gene, 38911 Neighboring gene STARR-seq mESC enhancer starr_17582 Neighboring gene predicted gene 14329 Neighboring gene predicted gene 14330 Neighboring gene STARR-seq mESC enhancer starr_17584 Neighboring gene predicted gene, 26653 Neighboring gene STARR-seq mESC enhancer starr_17586 Neighboring gene zinc finger protein 707 pseudogene Neighboring gene predicted gene, 26105

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D2 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables NMDA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NMDA glutamate receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables NMDA glutamate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NMDA glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellularly glutamate-gated ion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate binding ISO
Inferred from Sequence Orthology
more info
 
enables glutamate-gated calcium ion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate-gated receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables glycine binding ISO
Inferred from Sequence Orthology
more info
 
enables heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-1 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic cation channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
enables neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in NMDA selective glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in associative learning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in behavioral fear response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within behavioral response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transmembrane import into cytosol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in excitatory postsynaptic potential IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within excitatory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in ionotropic glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within learning IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory TAS
Traceable Author Statement
more info
PubMed 
involved_in long-term synaptic potentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within long-term synaptic potentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within memory IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic cation transport IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of dendritic spine maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glutamate secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in protein heterotetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuronal synaptic plasticity NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of neuronal synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of postsynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein kinase A signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organonitrogen compound ISO
Inferred from Sequence Orthology
more info
 
involved_in rhythmic process ISO
Inferred from Sequence Orthology
more info
 
involved_in sensitization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sensory organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within startle response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within startle response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within suckling behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of NMDA selective glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NMDA selective glutamate receptor complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of NMDA selective glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in apical dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic branch ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in hippocampal mossy fiber to CA3 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic cleft ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 
located_in transport vesicle membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
glutamate receptor ionotropic, NMDA 2B
Names
N-methyl D-aspartate receptor subtype 2B
glutamate [NMDA] receptor subunit epsilon-2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363750.1NP_001350679.1  glutamate receptor ionotropic, NMDA 2B precursor

    Status: VALIDATED

    Source sequence(s)
    AC124500, AC124590, AC132119, AC161364
    Consensus CDS
    CCDS20648.1
    UniProtKB/Swiss-Prot
    Q01097, Q9DCB2
    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06378
    Location:33388
    PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  2. NM_008171.4NP_032197.3  glutamate receptor ionotropic, NMDA 2B precursor

    See identical proteins and their annotated locations for NP_032197.3

    Status: VALIDATED

    Source sequence(s)
    AC124500, AC124590, AC132119, AC161364
    Consensus CDS
    CCDS20648.1
    UniProtKB/Swiss-Prot
    Q01097, Q9DCB2
    UniProtKB/TrEMBL
    G3X9V4
    Related
    ENSMUSP00000107536.2, ENSMUST00000111905.8
    Conserved Domains (3) summary
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06378
    Location:33388
    PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    135690219..136150658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241221.4XP_011239523.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    See identical proteins and their annotated locations for XP_011239523.1

    UniProtKB/Swiss-Prot
    Q01097, Q9DCB2
    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06378
    Location:33388
    PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  2. XM_006505575.5XP_006505638.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    See identical proteins and their annotated locations for XP_006505638.1

    UniProtKB/Swiss-Prot
    Q01097, Q9DCB2
    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06378
    Location:33388
    PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  3. XM_006505574.5XP_006505637.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    See identical proteins and their annotated locations for XP_006505637.1

    UniProtKB/Swiss-Prot
    Q01097, Q9DCB2
    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06378
    Location:33388
    PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  4. XM_006505573.5XP_006505636.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    See identical proteins and their annotated locations for XP_006505636.1

    UniProtKB/Swiss-Prot
    Q01097, Q9DCB2
    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06378
    Location:33388
    PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  5. XM_036165858.1XP_036021751.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    UniProtKB/Swiss-Prot
    Q01097, Q9DCB2
    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06378
    Location:33388
    PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus