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Gsr glutathione reductase [ Mus musculus (house mouse) ]

Gene ID: 14782, updated on 8-Feb-2024

Summary

Official Symbol
Gsrprovided by MGI
Official Full Name
glutathione reductaseprovided by MGI
Primary source
MGI:MGI:95804
See related
Ensembl:ENSMUSG00000031584 AllianceGenome:MGI:95804
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gr1; Gr-1; D8Ertd238e
Summary
Enables glutathione-disulfide reductase (NADPH) activity. Predicted to be involved in several processes, including cell redox homeostasis; cellular response to oxidative stress; and glutathione metabolic process. Located in external side of plasma membrane. Is expressed in brain ventricular layer; gut; lung; metanephros; and retina. Human ortholog(s) of this gene implicated in cataract and macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 47.5), kidney adult (RPKM 30.5) and 28 other tissues See more
Orthologs
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Genomic context

See Gsr in Genome Data Viewer
Location:
8 A4; 8 20.69 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (34143266..34188190)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (33653238..33698162)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform Neighboring gene UBX domain protein 8 Neighboring gene STARR-positive B cell enhancer ABC_E4996 Neighboring gene STARR-seq mESC enhancer starr_21112 Neighboring gene predicted gene, 33433 Neighboring gene predicted gene, 24727 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene predicted gene, 40485 Neighboring gene RIKEN cDNA 1700104B16 gene Neighboring gene general transcription factor II E, polypeptide 2 (beta subunit)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (other) (1)  1 citation
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADP binding ISO
Inferred from Sequence Orthology
more info
 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables glutathione binding ISO
Inferred from Sequence Orthology
more info
 
enables glutathione-disulfide reductase (NADP) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutathione-disulfide reductase (NADP) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutathione-disulfide reductase (NADP) activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular oxidant detoxification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within glutathione metabolic process IC
Inferred by Curator
more info
PubMed 
involved_in glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
glutathione reductase, mitochondrial
Names
GR
GRase
glutathione reductase 1
NP_034474.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010344.4NP_034474.4  glutathione reductase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_034474.4

    Status: VALIDATED

    Source sequence(s)
    BC056357, BQ178602
    Consensus CDS
    CCDS22235.1
    UniProtKB/Swiss-Prot
    P47791, Q7TNC2, Q8BN97, Q8C9Z6
    UniProtKB/TrEMBL
    Q3TWI5
    Related
    ENSMUSP00000033992.9, ENSMUST00000033992.9
    Conserved Domains (3) summary
    TIGR01421
    Location:42500
    gluta_reduc_1; glutathione-disulfide reductase, animal/bacterial
    pfam00070
    Location:211287
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:390498
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    34143266..34188190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)