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Gsr glutathione reductase [ Mus musculus (house mouse) ]

Gene ID: 14782, updated on 9-Sep-2018

Summary

Official Symbol
Gsrprovided by MGI
Official Full Name
glutathione reductaseprovided by MGI
Primary source
MGI:MGI:95804
See related
Ensembl:ENSMUSG00000031584 Vega:OTTMUSG00000016634
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gr1; Gr-1; AI325518; D8Ertd238e
Expression
Ubiquitous expression in large intestine adult (RPKM 47.5), kidney adult (RPKM 30.5) and 28 other tissues See more
Orthologs

Genomic context

See Gsr in Genome Data Viewer
Location:
8 A3; 8 20.69 cM
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (33653238..33698162)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (34763710..34808634)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform Neighboring gene UBX domain protein 8 Neighboring gene predicted gene, 33433 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene predicted gene, 40485 Neighboring gene general transcription factor II E, polypeptide 2 (beta subunit) Neighboring gene small integral membrane protein 18

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (other) (1)  1 citation
  • Gene trapped (1) 

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NADP binding ISO
Inferred from Sequence Orthology
more info
 
electron transfer activity IEA
Inferred from Electronic Annotation
more info
 
flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
glutathione binding ISO
Inferred from Sequence Orthology
more info
 
glutathione-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione-disulfide reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione-disulfide reductase activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione metabolic process IC
Inferred by Curator
more info
PubMed 
glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutathione reductase, mitochondrial
Names
GR
GRase
glutathione reductase 1
NP_034474.4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010344.4NP_034474.4  glutathione reductase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_034474.4

    Status: VALIDATED

    Source sequence(s)
    BC056357, BQ178602
    Consensus CDS
    CCDS22235.1
    UniProtKB/Swiss-Prot
    P47791
    Related
    ENSMUSP00000033992.8, OTTMUSP00000017970, ENSMUST00000033992.8, OTTMUST00000040242
    Conserved Domains (3) summary
    TIGR01421
    Location:42500
    gluta_reduc_1; glutathione-disulfide reductase, animal/bacterial
    pfam00070
    Location:211287
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:390498
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    33653238..33698162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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