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Gnmt glycine N-methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 14711, updated on 6-Jun-2024

Summary

Official Symbol
Gnmtprovided by MGI
Official Full Name
glycine N-methyltransferaseprovided by MGI
Primary source
MGI:MGI:1202304
See related
Ensembl:ENSMUSG00000002769 AllianceGenome:MGI:1202304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables glycine N-methyltransferase activity and glycine binding activity. Involved in S-adenosylmethionine metabolic process and protein homotetramerization. Acts upstream of or within several processes, including glycogen metabolic process; one-carbon metabolic process; and regulation of gluconeogenesis. Predicted to be located in nucleus. Predicted to be part of methyltransferase complex. Predicted to be active in cytosol. Is expressed in several structures, including integumental system; limb; nose; pancreas tip epithelium; and skeleton. Used to study glycine N-methyltransferase deficiency and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in glycine N-methyltransferase deficiency. Orthologous to human GNMT (glycine N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward liver adult (RPKM 1724.9) See more
Orthologs
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Genomic context

See Gnmt in Genome Data Viewer
Location:
17 22.9 cM; 17 C
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47036590..47040091, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46725664..46729211, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene male enhanced antigen 1 Neighboring gene protein phosphatase 2, regulatory subunit B', delta Neighboring gene STARR-positive B cell enhancer ABC_E7538 Neighboring gene peroxisomal biogenesis factor 6 Neighboring gene canopy FGF signaling regulator 3 Neighboring gene STARR-positive B cell enhancer ABC_E2490 Neighboring gene STARR-positive B cell enhancer ABC_E3204 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:46900557-46900758 Neighboring gene pre T cell antigen receptor alpha

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S-adenosyl-L-methionine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables S-adenosyl-L-methionine binding ISO
Inferred from Sequence Orthology
more info
 
enables S-adenosylmethionine-dependent methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables folic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables glycine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glycine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables glycine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glycine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables glycine binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in S-adenosylhomocysteine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in S-adenosylhomocysteine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in S-adenosylmethionine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in S-adenosylmethionine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in S-adenosylmethionine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycine metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within methionine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within one-carbon metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein homotetramerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein homotetramerization IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sarcosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sarcosine metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of methyltransferase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glycine N-methyltransferase
Names
glycine N methyl transferase
NP_001351819.1
NP_001400081.1
NP_034451.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364890.1NP_001351819.1  glycine N-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT030702
    UniProtKB/TrEMBL
    Q5I0T9
    Conserved Domains (1) summary
    pfam13649
    Location:61146
    Methyltransf_25; Methyltransferase domain
  2. NM_001413152.1NP_001400081.1  glycine N-methyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT030702
    UniProtKB/TrEMBL
    Q5I0T9
  3. NM_010321.1NP_034451.1  glycine N-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_034451.1

    Status: VALIDATED

    Source sequence(s)
    D89664
    Consensus CDS
    CCDS28838.1
    UniProtKB/Swiss-Prot
    Q91WN7, Q9QXF8
    UniProtKB/TrEMBL
    Q5I0T9
    Related
    ENSMUSP00000002846.9, ENSMUST00000002846.9
    Conserved Domains (1) summary
    pfam12847
    Location:60175
    Methyltransf_18; Methyltransferase domain

RNA

  1. NR_182115.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT030702

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    47036590..47040091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)