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SLFN13 schlafen family member 13 [ Homo sapiens (human) ]

Gene ID: 146857, updated on 1-Jun-2020

Summary

Official Symbol
SLFN13provided by HGNC
Official Full Name
schlafen family member 13provided by HGNC
Primary source
HGNC:HGNC:26481
See related
Ensembl:ENSG00000154760 MIM:614957
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLFN10; hSLFN13
Expression
Broad expression in bone marrow (RPKM 5.2), spleen (RPKM 4.2) and 24 other tissues See more
Orthologs

Genomic context

See SLFN13 in Genome Data Viewer
Location:
17q12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (35435096..35451103, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (33762115..33775856, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ubiquitin fold modifier 1 pseudogene Neighboring gene DTW domain containing 2 pseudogene Neighboring gene schlafen family member 12 Neighboring gene adenylosuccinate synthase 2 pseudogene Neighboring gene schlafen family member 12 like Neighboring gene E2F transcription factor 3 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31952, DKFZp666J196, DKFZp686I026

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
endoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
tRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
schlafen family member 13
Names
schlafen-13

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144682.6NP_653283.3  schlafen family member 13

    See identical proteins and their annotated locations for NP_653283.3

    Status: VALIDATED

    Source sequence(s)
    AC015911, AC060766, CR749630, DA720331
    Consensus CDS
    CCDS32620.1
    UniProtKB/Swiss-Prot
    Q68D06
    Related
    ENSP00000285013.6, ENST00000285013.11
    Conserved Domains (3) summary
    cl21455
    Location:595676
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:848895
    UvrD_C_2; UvrD-like helicase C-terminal domain
    cl27772
    Location:15347
    B3R; Poxviridae B3 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    35435096..35451103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450615.1XP_024306383.1  schlafen family member 13 isoform X1

    Conserved Domains (3) summary
    cl21455
    Location:595676
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:848895
    UvrD_C_2; UvrD-like helicase C-terminal domain
    cl27772
    Location:15347
    B3R; Poxviridae B3 protein
  2. XM_024450614.1XP_024306382.1  schlafen family member 13 isoform X1

    Conserved Domains (3) summary
    cl21455
    Location:595676
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:848895
    UvrD_C_2; UvrD-like helicase C-terminal domain
    cl27772
    Location:15347
    B3R; Poxviridae B3 protein
  3. XM_011524383.2XP_011522685.1  schlafen family member 13 isoform X2

    See identical proteins and their annotated locations for XP_011522685.1

    UniProtKB/TrEMBL
    B3KV92
    Related
    ENSP00000435442.1, ENST00000534689.5
    Conserved Domains (2) summary
    cl21455
    Location:264345
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:517564
    UvrD_C_2; UvrD-like helicase C-terminal domain
  4. XM_017024233.1XP_016879722.1  schlafen family member 13 isoform X1

    UniProtKB/Swiss-Prot
    Q68D06
    Conserved Domains (3) summary
    cl21455
    Location:595676
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:848895
    UvrD_C_2; UvrD-like helicase C-terminal domain
    cl27772
    Location:15347
    B3R; Poxviridae B3 protein
  5. XM_017024232.1XP_016879721.1  schlafen family member 13 isoform X1

    UniProtKB/Swiss-Prot
    Q68D06
    Conserved Domains (3) summary
    cl21455
    Location:595676
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:848895
    UvrD_C_2; UvrD-like helicase C-terminal domain
    cl27772
    Location:15347
    B3R; Poxviridae B3 protein
  6. XM_005257922.2XP_005257979.1  schlafen family member 13 isoform X1

    See identical proteins and their annotated locations for XP_005257979.1

    UniProtKB/Swiss-Prot
    Q68D06
    Related
    ENSP00000467426.1, ENST00000533791.5
    Conserved Domains (3) summary
    cl21455
    Location:595676
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:848895
    UvrD_C_2; UvrD-like helicase C-terminal domain
    cl27772
    Location:15347
    B3R; Poxviridae B3 protein
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