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RTN4RL1 reticulon 4 receptor like 1 [ Homo sapiens (human) ]

Gene ID: 146760, updated on 11-Jun-2021

Summary

Official Symbol
RTN4RL1provided by HGNC
Official Full Name
reticulon 4 receptor like 1provided by HGNC
Primary source
HGNC:HGNC:21329
See related
Ensembl:ENSG00000185924 MIM:610461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NgR3; NGRH2
Expression
Broad expression in brain (RPKM 5.0), fat (RPKM 3.0) and 14 other tissues See more
Orthologs
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Genomic context

See RTN4RL1 in Genome Data Viewer
Location:
17p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (1934677..2025334, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1837971..1928628, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4981 Neighboring gene SET and MYND domain containing 4 Neighboring gene replication protein A1 Neighboring gene succinate dehydrogenase complex subunit C pseudogene Neighboring gene uncharacterized LOC105371486 Neighboring gene uncharacterized LOC105371485 Neighboring gene diphthamide biosynthesis 1 Neighboring gene microRNA 132 Neighboring gene OVCA2 serine hydrolase domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp547J144

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chondroitin sulfate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in axon regeneration TAS
Traceable Author Statement
more info
PubMed 
involved_in corpus callosum development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of axon regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in anchored component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
reticulon-4 receptor-like 1
Names
Nogo-66 receptor homolog 2
Nogo-66 receptor-related protein 3
nogo receptor-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178568.4NP_848663.1  reticulon-4 receptor-like 1 precursor

    See identical proteins and their annotated locations for NP_848663.1

    Status: VALIDATED

    Source sequence(s)
    AC099684, AC130689
    Consensus CDS
    CCDS45569.1
    UniProtKB/Swiss-Prot
    Q86UN2
    Related
    ENSP00000330631.4, ENST00000331238.7
    Conserved Domains (3) summary
    sd00033
    Location:5777
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:174233
    LRR_8; Leucine rich repeat
    cl15307
    Location:255300
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    1934677..2025334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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