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RTN4RL1 reticulon 4 receptor like 1 [ Homo sapiens (human) ]

Gene ID: 146760, updated on 12-Aug-2018

Summary

Official Symbol
RTN4RL1provided by HGNC
Official Full Name
reticulon 4 receptor like 1provided by HGNC
Primary source
HGNC:HGNC:21329
See related
Ensembl:ENSG00000185924 MIM:610461; Vega:OTTHUMG00000180184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NgR3; NGRH2
Expression
Broad expression in brain (RPKM 5.0), fat (RPKM 3.0) and 14 other tissues See more
Orthologs

Genomic context

See RTN4RL1 in Genome Data Viewer
Location:
17p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (1934677..2025345, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1837971..1928178, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing 4 Neighboring gene replication protein A1 Neighboring gene succinate dehydrogenase complex subunit C pseudogene Neighboring gene uncharacterized LOC105371486 Neighboring gene uncharacterized LOC105371485 Neighboring gene diphthamide biosynthesis 1 Neighboring gene microRNA 132 Neighboring gene OVCA2, serine hydrolase domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp547J144

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chondroitin sulfate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
axon regeneration TAS
Traceable Author Statement
more info
PubMed 
corpus callosum development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of axon regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
anchored component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
reticulon-4 receptor-like 1
Names
Nogo-66 receptor homolog 2
Nogo-66 receptor-related protein 3
nogo receptor-like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178568.3NP_848663.1  reticulon-4 receptor-like 1 precursor

    See identical proteins and their annotated locations for NP_848663.1

    Status: VALIDATED

    Source sequence(s)
    AC099684, AC130689
    Consensus CDS
    CCDS45569.1
    UniProtKB/Swiss-Prot
    Q86UN2
    Related
    ENSP00000330631.4, OTTHUMP00000263560, ENST00000331238.6, OTTHUMT00000450155
    Conserved Domains (3) summary
    sd00033
    Location:5777
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:174233
    LRR_8; Leucine rich repeat
    cl15307
    Location:255300
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    1934677..2025345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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