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CD300LF CD300 molecule like family member f [ Homo sapiens (human) ]

Gene ID: 146722, updated on 29-Mar-2020

Summary

Official Symbol
CD300LFprovided by HGNC
Official Full Name
CD300 molecule like family member fprovided by HGNC
Primary source
HGNC:HGNC:29883
See related
Ensembl:ENSG00000186074 MIM:609807
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLM1; NKIR; CLM-1; IREM1; LMIR3; CD300f; IREM-1; IgSF13
Summary
This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression
Biased expression in spleen (RPKM 9.3), bone marrow (RPKM 8.2) and 10 other tissues See more
Orthologs

Genomic context

See CD300LF in Genome Data Viewer
Location:
17q25.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (74694308..74713000, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72690447..72709169, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928343 Neighboring gene CD300e molecule Neighboring gene uncharacterized LOC105371894 Neighboring gene RAB37, member RAS oncogene family Neighboring gene uncharacterized LOC105371893 Neighboring gene SLC9A3 regulator 1 Neighboring gene microRNA 3615 Neighboring gene N-acetyltransferase 9 (putative)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
NHGRI GWA Catalog
Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ceramide binding IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-4 receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
TRIF-dependent toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
interleukin-13-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of MyD88-dependent toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic cell clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of mast cell activation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic cell clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-4-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
CMRF35-like molecule 1
Names
CD300 antigen-like family member F
NK inhibitory receptor
immune receptor expressed on myeloid cells 1
immunoglobin superfamily member 13
immunoglobulin superfamily member 13
inhibitory receptor IREM1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289082.2NP_001276011.1  CMRF35-like molecule 1 isoform 2

    See identical proteins and their annotated locations for NP_001276011.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as sv3) differs in its 5' UTR, uses an alternate start codon, and lacks an exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    BC028199, BM680508, BM923728, DA673169
    Consensus CDS
    CCDS74148.1
    UniProtKB/Swiss-Prot
    Q8TDQ1
    Related
    ENSP00000463743.1, ENST00000469092.5
    Conserved Domains (2) summary
    cd05716
    Location:30128
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:28128
    IG_like; Immunoglobulin like
  2. NM_001289083.2NP_001276012.1  CMRF35-like molecule 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001276012.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK092757, BI911496, BM680508, BM923728, BP226373
    Consensus CDS
    CCDS74151.1
    UniProtKB/Swiss-Prot
    Q8TDQ1
    Related
    ENSP00000301573.9, ENST00000301573.13
    Conserved Domains (2) summary
    cd05716
    Location:27125
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:25125
    IG_like; Immunoglobulin like
  3. NM_001289084.2NP_001276013.1  CMRF35-like molecule 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (4) is longer, compared to isoform 1.
    Source sequence(s)
    AK298752, BI911496, BM680508, BM923728
    Consensus CDS
    CCDS74152.1
    UniProtKB/Swiss-Prot
    Q8TDQ1
    UniProtKB/TrEMBL
    B4DQD2, J3KS52
    Related
    ENSP00000462309.1, ENST00000583937.5
    Conserved Domains (3) summary
    cd05716
    Location:27125
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:25125
    IG_like; Immunoglobulin like
    pfam15330
    Location:193274
    SIT; SHP2-interacting transmembrane adaptor protein, SIT
  4. NM_001289085.2NP_001276014.1  CMRF35-like molecule 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as sv1) differs in its 5' UTR, and uses an alternate start codon, compared to variant 1. The encoded isoform (5) has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF375480, BC028199, BI911496, BM680508, BM923728
    Consensus CDS
    CCDS74149.1
    UniProtKB/Swiss-Prot
    Q8TDQ1
    Related
    ENSP00000464257.1, ENST00000464910.5
    Conserved Domains (3) summary
    cd05716
    Location:30128
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:28128
    IG_like; Immunoglobulin like
    pfam15330
    Location:181262
    SIT; SHP2-interacting transmembrane adaptor protein, SIT
  5. NM_001289086.2NP_001276015.1  CMRF35-like molecule 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR, uses an alternate start codon, and lacks an exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (6) is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    BC028199, BI911496, BM680508, BM923728, DQ153249
    Consensus CDS
    CCDS74150.1
    UniProtKB/Swiss-Prot
    Q8TDQ1
    Related
    ENSP00000355294.4, ENST00000361254.8
    Conserved Domains (2) summary
    cd05716
    Location:30128
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:28128
    IG_like; Immunoglobulin like
  6. NM_001289087.2NP_001276016.1  CMRF35-like molecule 1 isoform 7 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an exon in the central coding region, which results in a frameshift, compared to variant (1). The encoded isoform (7) has a shorter and distinct C-terminus, compared to variant 1.
    Source sequence(s)
    BC028199, BI911496, BM680508, BM922663, BM923728
    UniProtKB/Swiss-Prot
    Q8TDQ1
    Conserved Domains (2) summary
    cd05716
    Location:27125
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:25125
    IG_like; Immunoglobulin like
  7. NM_139018.5NP_620587.2  CMRF35-like molecule 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_620587.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AY358545, BM680508, BM923728, DA673169
    Consensus CDS
    CCDS11704.1
    UniProtKB/Swiss-Prot
    Q8TDQ1
    Related
    ENSP00000327075.6, ENST00000326165.11
    Conserved Domains (3) summary
    cd05716
    Location:27125
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:25125
    IG_like; Immunoglobulin like
    pfam15330
    Location:178259
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

RNA

  1. NR_110298.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8, also known as sv2) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF375481, BC028199, BI911496, BM680508, BM923728

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    74694308..74713000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024215.1XP_016879704.1  CMRF35-like molecule 1 isoform X4

  2. XM_017024212.2XP_016879701.1  CMRF35-like molecule 1 isoform X1

  3. XM_017024214.2XP_016879703.1  CMRF35-like molecule 1 isoform X3

  4. XM_017024213.2XP_016879702.1  CMRF35-like molecule 1 isoform X2

  5. XM_017024217.2XP_016879706.1  CMRF35-like molecule 1 isoform X6

  6. XM_017024216.2XP_016879705.1  CMRF35-like molecule 1 isoform X5

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