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Gls glutaminase [ Mus musculus (house mouse) ]

Gene ID: 14660, updated on 21-Apr-2024

Summary

Official Symbol
Glsprovided by MGI
Official Full Name
glutaminaseprovided by MGI
Primary source
MGI:MGI:95752
See related
Ensembl:ENSMUSG00000026103 AllianceGenome:MGI:95752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330442B14; B230365M23Rik
Summary
Enables glutaminase activity and identical protein binding activity. Involved in glutamate biosynthetic process; glutamine catabolic process; and protein homotetramerization. Acts upstream of or within chemical synaptic transmission; regulation of respiratory gaseous exchange by nervous system process; and suckling behavior. Predicted to be located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to human GLS (glutaminase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 20.0), cortex adult (RPKM 19.9) and 26 other tissues See more
Orthologs
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Genomic context

Location:
1 C1.1; 1 26.86 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52202608..52274168, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52163449..52235009, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 4 Neighboring gene STARR-seq mESC enhancer starr_00894 Neighboring gene STARR-positive B cell enhancer ABC_E10010 Neighboring gene predicted gene, 31812 Neighboring gene STARR-positive B cell enhancer ABC_E3272 Neighboring gene STARR-positive B cell enhancer ABC_E3273 Neighboring gene signal transducer and activator of transcription 1 Neighboring gene transmembrane protein 209 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7722 Neighboring gene STARR-positive B cell enhancer ABC_E1992 Neighboring gene predicted gene, 31867 Neighboring gene tripartite motif-containing 75 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (7) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutaminase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables glutaminase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutaminase kidney isoform, mitochondrial
NP_001074550.1
NP_001106854.1
XP_006495764.1
XP_006495765.1
XP_006495767.1
XP_017171725.1
XP_036016518.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081081.2NP_001074550.1  glutaminase kidney isoform, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001074550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC123752
    Consensus CDS
    CCDS35561.1
    UniProtKB/Swiss-Prot
    D3Z7P3, E9PUF0, Q69ZX9
    Related
    ENSMUSP00000110158.3, ENSMUST00000114513.9
    Conserved Domains (4) summary
    sd00045
    Location:562588
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:562652
    Ank_2; Ankyrin repeats (3 copies)
    pfam17959
    Location:144227
    EF-hand_14; EF-hand domain
    pfam04960
    Location:249535
    Glutaminase
  2. NM_001113383.1NP_001106854.1  glutaminase kidney isoform, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon, compared to variant 1, resulting in a shorter protein (isoform 2) that has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK173039, BE849049
    Consensus CDS
    CCDS48256.1
    UniProtKB/Swiss-Prot
    D3Z7P3
    Related
    ENSMUSP00000110155.2, ENSMUST00000114510.8
    Conserved Domains (1) summary
    pfam04960
    Location:249535
    Glutaminase; Glutaminase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    52202608..52274168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316236.2XP_017171725.1  glutaminase kidney isoform, mitochondrial isoform X4

    Conserved Domains (3) summary
    sd00045
    Location:224250
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:224314
    Ank_2; Ankyrin repeats (3 copies)
    pfam04960
    Location:9197
    Glutaminase
  2. XM_036160625.1XP_036016518.1  glutaminase kidney isoform, mitochondrial isoform X2

    UniProtKB/TrEMBL
    D3Z7P4
    Conserved Domains (3) summary
    sd00045
    Location:333359
    ANK; ANK repeat [structural motif]
    pfam04960
    Location:20304
    Glutaminase
    pfam12796
    Location:333425
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_006495702.3XP_006495765.1  glutaminase kidney isoform, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006495765.1

    UniProtKB/TrEMBL
    D3Z7P4
    Related
    ENSMUSP00000110157.2, ENSMUST00000114512.8
    Conserved Domains (3) summary
    sd00045
    Location:333359
    ANK; ANK repeat [structural motif]
    pfam04960
    Location:20304
    Glutaminase
    pfam12796
    Location:333425
    Ank_2; Ankyrin repeats (3 copies)
  4. XM_006495701.4XP_006495764.1  glutaminase kidney isoform, mitochondrial isoform X1

    Conserved Domains (2) summary
    pfam17959
    Location:144227
    EF-hand_14; EF-hand domain
    pfam04960
    Location:249535
    Glutaminase
  5. XM_006495704.5XP_006495767.1  glutaminase kidney isoform, mitochondrial isoform X3

    Conserved Domains (2) summary
    pfam17959
    Location:144227
    EF-hand_14; EF-hand domain
    cl00907
    Location:249353
    Glutaminase