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Glul glutamate-ammonia ligase (glutamine synthetase) [ Mus musculus (house mouse) ]

Gene ID: 14645, updated on 17-Jan-2023

Summary

Official Symbol
Glulprovided by MGI
Official Full Name
glutamate-ammonia ligase (glutamine synthetase)provided by MGI
Primary source
MGI:MGI:95739
See related
Ensembl:ENSMUSG00000026473 AllianceGenome:MGI:95739
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GS; Glns
Summary
Predicted to enable several functions, including anion binding activity; dynein light chain binding activity; and metal ion binding activity. Involved in regulation of endothelial cell migration and regulation of sprouting angiogenesis. Acts upstream of or within cellular response to starvation and response to glucose. Located in cell body; cytoplasm; and glial cell projection. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and urinary system. Used to study temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and temporal lobe epilepsy. Orthologous to human GLUL (glutamate-ammonia ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 555.7), frontal lobe adult (RPKM 388.8) and 24 other tissues See more
Orthologs
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Genomic context

See Glul in Genome Data Viewer
Location:
1; 1 G3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (153775675..153785469)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (153899929..153909723)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene transmembrane epididymal protein 1B Neighboring gene transmembrane epididymal protein 1A Neighboring gene microRNA 8114 Neighboring gene predicted gene, 30327 Neighboring gene predicted gene 28286 Neighboring gene predicted gene, 46165 Neighboring gene predicted gene, 25336

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables dynein light chain binding ISO
Inferred from Sequence Orthology
more info
 
enables glutamate binding ISO
Inferred from Sequence Orthology
more info
 
enables glutamate-ammonia ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutamate-ammonia ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ammonia assimilation cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in glutamate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glutamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glutamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nitrogen compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization to nucleolus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosome biogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in glial cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamine synthetase
Names
glutamate decarboxylase
glutamate-ammonia ligase (glutamine synthase)
palmitoyltransferase GLUL
NP_032157.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008131.5NP_032157.2  glutamine synthetase

    See identical proteins and their annotated locations for NP_032157.2

    Status: VALIDATED

    Source sequence(s)
    AC099702
    Consensus CDS
    CCDS15381.1
    UniProtKB/Swiss-Prot
    P15105, Q91VC6
    Related
    ENSMUSP00000083375.6, ENSMUST00000086199.12
    Conserved Domains (3) summary
    PLN02284
    Location:22362
    PLN02284; glutamine synthetase
    pfam00120
    Location:114356
    Gln-synt_C; Glutamine synthetase, catalytic domain
    pfam03951
    Location:30104
    Gln-synt_N; Glutamine synthetase, beta-Grasp domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    153775675..153785469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)