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Glul glutamate-ammonia ligase (glutamine synthetase) [ Mus musculus (house mouse) ]

Gene ID: 14645, updated on 18-Apr-2019

Summary

Official Symbol
Glulprovided by MGI
Official Full Name
glutamate-ammonia ligase (glutamine synthetase)provided by MGI
Primary source
MGI:MGI:95739
See related
Ensembl:ENSMUSG00000026473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GS; Glns
Expression
Broad expression in genital fat pad adult (RPKM 555.7), frontal lobe adult (RPKM 388.8) and 24 other tissues See more
Orthologs

Genomic context

See Glul in Genome Data Viewer
Location:
1; 1 G3
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (153899929..153909723)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (155747075..155756844)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene transmembrane epididymal protein 1A Neighboring gene predicted gene, 38440 Neighboring gene microRNA 8114 Neighboring gene uncharacterized LOC108167736 Neighboring gene predicted gene, 30327 Neighboring gene predicted gene, 46165

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
dynein light chain binding ISO
Inferred from Sequence Orthology
more info
 
glutamate binding ISO
Inferred from Sequence Orthology
more info
 
glutamate-ammonia ligase activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-cysteine S-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ammonia assimilation cycle ISO
Inferred from Sequence Orthology
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cellular response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
glutamate metabolic process ISO
Inferred from Sequence Orthology
more info
 
glutamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
nitrogen compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein palmitoylation ISO
Inferred from Sequence Orthology
more info
 
regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
regulation of protein localization to nucleolus ISO
Inferred from Sequence Orthology
more info
 
regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
response to glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosome biogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon terminus ISO
Inferred from Sequence Orthology
more info
 
cell body IDA
Inferred from Direct Assay
more info
PubMed 
cell projection ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
glial cell projection IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
myelin sheath HDA PubMed 
myelin sheath ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamine synthetase
Names
glutamate decarboxylase
glutamate-ammonia ligase (glutamine synthase)
palmitoyltransferase GLUL
NP_032157.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008131.4NP_032157.2  glutamine synthetase

    See identical proteins and their annotated locations for NP_032157.2

    Status: VALIDATED

    Source sequence(s)
    AC099702, AK159106, BE946110
    Consensus CDS
    CCDS15381.1
    UniProtKB/Swiss-Prot
    P15105
    Related
    ENSMUSP00000083375.5, ENSMUST00000086199.11
    Conserved Domains (3) summary
    PLN02284
    Location:22362
    PLN02284; glutamine synthetase
    pfam00120
    Location:114356
    Gln-synt_C; Glutamine synthetase, catalytic domain
    pfam03951
    Location:30104
    Gln-synt_N; Glutamine synthetase, beta-Grasp domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    153899929..153909723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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