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Gclm glutamate-cysteine ligase, modifier subunit [ Mus musculus (house mouse) ]

Gene ID: 14630, updated on 18-Sep-2024

Summary

Official Symbol
Gclmprovided by MGI
Official Full Name
glutamate-cysteine ligase, modifier subunitprovided by MGI
Primary source
MGI:MGI:104995
See related
Ensembl:ENSMUSG00000028124 AllianceGenome:MGI:104995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcmc; Glclr
Summary
Enables glutamate-cysteine ligase catalytic subunit binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; glutathione biosynthetic process; and positive regulation of glutamate-cysteine ligase activity. Part of glutamate-cysteine ligase complex. Is expressed in several structures, including alimentary system; liver; nervous system; urinary system; and vibrissa. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 93.5), liver E14 (RPKM 50.1) and 27 other tissues See more
Orthologs
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Genomic context

See Gclm in Genome Data Viewer
Location:
3 G1; 3 52.94 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (122039206..122060864)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (122245487..122267215)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46822 Neighboring gene STARR-seq mESC enhancer starr_08871 Neighboring gene predicted gene, 40137 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_08872 Neighboring gene STARR-positive B cell enhancer ABC_E6112 Neighboring gene STARR-seq mESC enhancer starr_08873 Neighboring gene peptidylprolyl isomerase A pseudogene 3_1245.1 Neighboring gene deoxynucleotidyltransferase, terminal, interacting protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E6113 Neighboring gene nuclear encoded tRNA arginine 2 (anticodon TCT) Neighboring gene predicted gene, 40190

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutamate-cysteine ligase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to glutamate-cysteine ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate-cysteine ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate-cysteine ligase catalytic subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutamate-cysteine ligase catalytic subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
enables glutamate-cysteine ligase catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables glutamate-cysteine ligase catalytic subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables glutamate-cysteine ligase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic mitochondrial changes IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in blood vessel diameter maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel diameter maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to fibroblast growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to follicle-stimulating hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hepatocyte growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to thyroxine stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cysteine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glutamate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glutamate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glutathione biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within glutathione biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glutathione biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glutathione biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within glutathione metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hepatic stellate cell activation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of glutamate-cysteine ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of mitochondrial depolarization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to activity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to human chorionic gonadotropin IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nitrosative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nitrosative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nutrient IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of glutamate-cysteine ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of glutamate-cysteine ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of glutamate-cysteine ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamate--cysteine ligase regulatory subunit
Names
GCS light chain
gamma-ECS regulatory subunit
gamma-glutamylcysteine synthetase regulatory subunit
NP_032155.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008129.4NP_032155.1  glutamate--cysteine ligase regulatory subunit

    See identical proteins and their annotated locations for NP_032155.1

    Status: VALIDATED

    Source sequence(s)
    AK028236, BB615104, DV659479
    Consensus CDS
    CCDS17808.1
    UniProtKB/Swiss-Prot
    O09172
    UniProtKB/TrEMBL
    Q3T9P2, Q4FJZ6
    Related
    ENSMUSP00000029769.8, ENSMUST00000029769.14
    Conserved Domains (1) summary
    cl00470
    Location:109211
    AKR_SF; Aldo-keto reductase (AKR) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    122039206..122060864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)