Format

Send to:

Choose Destination

Gja1 gap junction protein, alpha 1 [ Mus musculus (house mouse) ]

Gene ID: 14609, updated on 30-Nov-2021

Summary

Official Symbol
Gja1provided by MGI
Official Full Name
gap junction protein, alpha 1provided by MGI
Primary source
MGI:MGI:95713
See related
Ensembl:ENSMUSG00000050953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cx43; Npm1; Cnx43; Cxnk1; Gja-1; AU042049; AW546267; Cx43alpha1; connexin43
Expression
Broad expression in ovary adult (RPKM 68.8), heart adult (RPKM 61.3) and 18 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Gja1 in Genome Data Viewer
Location:
10 B4; 10 28.64 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (56253297..56266519)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (56377300..56390419)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (56097106..56110225)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 32 Neighboring gene MSL3 like 2 Neighboring gene UPF0183 protein C16orf70 homolog Neighboring gene ribosomal protein S8, pseudogene 1 Neighboring gene predicted gene, 36460 Neighboring gene predicted gene, 36517

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables connexin binding ISO
Inferred from Sequence Orthology
more info
 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables efflux transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables gap junction channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables gap junction channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables gap junction channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables gap junction channel activity ISO
Inferred from Sequence Orthology
more info
 
enables gap junction channel activity involved in cardiac conduction electrical coupling TAS
Traceable Author Statement
more info
PubMed 
enables gap junction channel activity involved in cell communication by electrical coupling ISO
Inferred from Sequence Orthology
more info
 
enables gap junction hemi-channel activity ISO
Inferred from Sequence Orthology
more info
 
enables glutathione transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ATP transport ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adult heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within atrial ventricular junction remodeling IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bone remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac conduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell communication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell communication by chemical coupling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell communication by electrical coupling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell-cell junction organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amyloid-beta IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to pH IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chronic inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epicardial cell to mesenchymal cell transition TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within epithelial cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of epithelial cell polarity TAS
Traceable Author Statement
more info
PubMed 
involved_in export across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glutamate secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lens development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of protein localization in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within milk ejection reflex IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of behavioral fear response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell communication by chemical coupling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glomerular filtration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of striated muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of atrial cardiac muscle cell membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood vessel remodeling TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of bone remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell communication by electrical coupling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane depolarization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane repolarization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane repolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to pH ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal muscle tissue regeneration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular transport ISO
Inferred from Sequence Orthology
more info
 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
part_of connexin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of connexin complex ISO
Inferred from Sequence Orthology
more info
 
located_in contractile fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in fascia adherens IDA
Inferred from Direct Assay
more info
PubMed 
located_in fascia adherens ISO
Inferred from Sequence Orthology
more info
 
located_in gap junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in gap junction ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in multivesicular body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in tight junction ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gap junction alpha-1 protein
Names
alpha 1 connexin
connexin k1
connexin-43
gap junction 43 kDa heart protein
gap junction membrane channel protein alpha 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010288.3NP_034418.1  gap junction alpha-1 protein

    See identical proteins and their annotated locations for NP_034418.1

    Status: VALIDATED

    Source sequence(s)
    AK081668, AK145692, BY061175
    Consensus CDS
    CCDS23851.1
    UniProtKB/Swiss-Prot
    P23242
    UniProtKB/TrEMBL
    Q8C4N2
    Related
    ENSMUSP00000064536.8, ENSMUST00000068581.9
    Conserved Domains (2) summary
    pfam00029
    Location:3233
    Connexin
    pfam03508
    Location:293312
    Connexin43; Gap junction alpha-1 protein (Cx43)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    56253297..56266519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155617.1XP_036011510.1  gap junction alpha-1 protein isoform X1

    Related
    ENSMUSP00000151620.2, ENSMUST00000220069.2
    Conserved Domains (2) summary
    pfam00029
    Location:3233
    Connexin
    pfam03508
    Location:293312
    Connexin43; Gap junction alpha-1 protein (Cx43)
Support Center