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B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 14595, updated on 2-Nov-2024

Summary

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Official Symbol
B4galt1provided by MGI
Official Full Name
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1provided by MGI
Primary source
MGI:MGI:95705
See related
Ensembl:ENSMUSG00000028413 AllianceGenome:MGI:95705
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GalT; Ggtb; Ggtb2; b4Gal-T1; B-1,4-GalT; B-1,4-GalT1; beta4Gal-T1; beta-1,4-GalT; beta-1,4-GalT1
Summary
This gene encodes two distinct enzyme isoforms, a long membrane-bound form and a short soluble form. These alternate isoforms are thought to be produced through alternative nested transcription initiation and different in-frame start codon usage. These enzymes catalyze the transfer of galactose to acceptor sugars, such as N-acetylglucosamine and glucose. The long form of this enzyme is localized to the trans-Golgi membrane and is involved in glycoconjugate biosynthesis. The short form functions in lactose biosynthesis though formation of a heterodimer with alpha-lactalbumin. [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in adrenal adult (RPKM 28.6), ovary adult (RPKM 25.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See B4galt1 in Genome Data Viewer
Location:
4 A5; 4 20.46 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (40804602..40855711, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (40804602..40853984, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) Neighboring gene STARR-positive B cell enhancer ABC_E7962 Neighboring gene STARR-positive B cell enhancer ABC_E4617 Neighboring gene STARR-seq mESC enhancer starr_09993 Neighboring gene presenilin enhancer gamma secretase subunit, pseudogene Neighboring gene predicted gene, 34213 Neighboring gene STARR-seq mESC enhancer starr_09997 Neighboring gene STARR-positive B cell enhancer ABC_E11234 Neighboring gene STARR-positive B cell enhancer mm9_chr4:40801010-40801311 Neighboring gene microRNA 5123 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:40822974-40823216 Neighboring gene STARR-positive B cell enhancer mm9_chr4:40823726-40824026 Neighboring gene predicted gene, 34289 Neighboring gene STARR-seq mESC enhancer starr_10005 Neighboring gene STARR-seq mESC enhancer starr_10006 Neighboring gene lysine (K)-specific demethylase 2B pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of two cis-regulatory regions in the murine beta 1,4-galactosyltransferase gene. Evidence for a negative regulatory element that controls initiation at the proximal site. Harduin-Lepers A, et al. J Biol Chem, 1993 Jul 5. PMID 8314795
  2. Determination of the half-life of the murine beta4-galactosyltransferase-1 mRNA in somatic cells using the tetracycline-controlled transcriptional regulation system. Scocca JR, et al. Biochimie, 2003 Mar-Apr. PMID 12770778
  3. Cell surface beta1,4-galactosyltransferase function in mammary gland morphogenesis: insights from transgenic and knockout mouse models. Hathaway HJ. J Mammary Gland Biol Neoplasia, 2003 Oct. PMID 14985638
  4. Targeted mutations in beta1,4-galactosyltransferase I reveal its multiple cellular functions. Rodeheffer C, et al. Biochim Biophys Acta, 2002 Dec 19. PMID 12417408
  5. Cell surface beta-1,4-galactosyltransferase-I activates G protein-dependent exocytotic signaling. Shi X, et al. Development, 2001 Mar. PMID 11171390

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. beta-1,4-Galactosyltransferase 1 protects against cerebral ischemia injury in mice by suppressing ferroptosis via the TAZ/Nrf2/HO-1 signaling pathway.
    Title: β-1,4-Galactosyltransferase 1 protects against cerebral ischemia injury in mice by suppressing ferroptosis via the TAZ/Nrf2/HO-1 signaling pathway.
  2. Transcriptional Mechanism of the Mouse beta4-Galactosyltransferase 6 Gene in Mouse Neuroblastoma Cell Line Neuro-2a.
    Title: Transcriptional Mechanism of the Mouse β4-Galactosyltransferase 6 Gene in Mouse Neuroblastoma Cell Line Neuro-2a.
  3. MicroRNA-15a/beta1,4-GalT-I axis contributes to cartilage degeneration via NF-kappaB signaling in osteoarthritis.
    Title: MicroRNA-15a/β1,4-GalT-I axis contributes to cartilage degeneration via NF-κB signaling in osteoarthritis.
  4. B-cell-specific ablation of beta-1,4-galactosyltransferase 1 prevents aging-related IgG glycans changes and improves aging phenotype in mice.
    Title: B-cell-specific ablation of β-1,4-galactosyltransferase 1 prevents aging-related IgG glycans changes and improves aging phenotype in mice.
  5. Aberration of Serum and Tissue N-Glycans in Mouse beta1,4-GalT1 Y286L Mutant Variants.
    Title: Aberration of Serum and Tissue N-Glycans in Mouse β1,4-GalT1 Y286L Mutant Variants.
  6. beta4GALT1 controls beta1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis.
    Title: β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis.
  7. Ganglioside Synthase Knockout Reduces Prion Disease Incubation Time in Mouse Models.
    Title: Ganglioside Synthase Knockout Reduces Prion Disease Incubation Time in Mouse Models.
  8. The loss of the long GalT-I isoform also leads to a loss of actin stress fibers, focal adhesions and rac GTPase activation.
    Title: Mouse fibroblasts null for the long isoform of β1,4-galactosyltransferase-I show defective cell-matrix interactions.
  9. beta4GalT1 can regulate N-glycans of CXCR3 in RA. N-glycans of CXCR3 affects CXCL10/CXCR3 ligand-binding which enhancing fibroblast-like synoviocytes invasion.
    Title: The β4GalT1 affects the fibroblast-like synoviocytes invasion in rheumatoid arthritis by modifying N-linked glycosylation of CXCR3.
  10. Beta 1,4-galactosyltransferase I possibly regulate mutual uterus-embryo adhesion and embryo implantation by regulating cell surface Le(Y) glycan expression.
    Title: Regulatory function of β1,4-galactosyltransferase I expression on Lewis-Y glycan and embryo implantation.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyllactosamine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables N-acetyllactosamine synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables galactosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lactose synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lactose synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within acute inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within angiogenesis involved in wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within binding of sperm to zona pellucida IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within binding of sperm to zona pellucida IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within cell adhesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within development of secondary sexual characteristics IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epithelial cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within galactose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glycoprotein biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lactose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lactose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within macrophage migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within oligosaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within penetration of zona pellucida IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of circulating fibrinogen levels ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of circulating fibrinogen levels ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of acrosome reaction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi trans cisterna IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi trans cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane IEA
Inferred from Electronic Annotation
more info
  
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in desmosome IEA
Inferred from Electronic Annotation
more info
  
located_in desmosome ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in filopodium IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
beta-1,4-galactosyltransferase 1
Names
N-acetyllactosamine synthase
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1
b1,4-Galactosyltransferase I
beta-1,4-GalTase 1
beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
galactosyltransferase 2 beta 1, 4
glycoprotein galactosyltransferase beta 1, 4
lactose synthase A protein
nal synthase
neolactotriaosylceramide beta-1,4-galactosyltransferase
NP_001365448.1
NP_071641.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378519.2 → NP_001365448.1  beta-1,4-galactosyltransferase 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AEKQ02033059, AL833775
    UniProtKB/TrEMBL
    B1AXY5, Q3TJS1
    Conserved Domains (1) summary
    cd00899
    Location:163 → 381
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

  2. NM_022305.6 → NP_071641.1  beta-1,4-galactosyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_071641.1

    Status: REVIEWED

    Source sequence(s)
    AEKQ02033059, AL833775
    Consensus CDS
    CCDS18051.1
    UniProtKB/Swiss-Prot
    P15535
    UniProtKB/TrEMBL
    B1AXY5, Q3U478
    Related
    ENSMUSP00000030121.7, ENSMUST00000030121.13
    Conserved Domains (1) summary
    cd00899
    Location:176 → 394
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RNA

  1. NR_165793.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AEKQ02033059, AL833775

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    40804602..40855711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004941815.1 RNA Sequence

  2. XR_004941814.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15535.1 GenPept UniProtKB/Swiss-Prot:P15535

Gene LinkOut

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