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MESP2 mesoderm posterior bHLH transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 145873, updated on 13-Mar-2020

Summary

Official Symbol
MESP2provided by HGNC
Official Full Name
mesoderm posterior bHLH transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:29659
See related
Ensembl:ENSG00000188095 MIM:605195
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCDO2; bHLHc6
Summary
This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See MESP2 in Genome Data Viewer
Location:
15q26.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (89776332..89778754)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90319589..90321985)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene WD repeat domain 93 Neighboring gene mesoderm posterior bHLH transcription factor 1 Neighboring gene mitochondrial ribosomal protein L15 pseudogene 1 Neighboring gene alanyl aminopeptidase, membrane Neighboring gene FOXA motif-containing MPRA enhancer 170 Neighboring gene uncharacterized LOC105370965

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
heart morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mesoderm formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
somitogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mesoderm posterior protein 2
Names
class C basic helix-loop-helix protein 6
mesoderm posterior 2 homolog
mesoderm posterior basic helix-loop-helix transcription factor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008608.2 RefSeqGene

    Range
    20742..23164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039958.2NP_001035047.1  mesoderm posterior protein 2

    See identical proteins and their annotated locations for NP_001035047.1

    Status: REVIEWED

    Source sequence(s)
    AC079075
    Consensus CDS
    CCDS42078.1
    UniProtKB/Swiss-Prot
    Q0VG99
    Related
    ENSP00000342392.3, ENST00000341735.5
    Conserved Domains (1) summary
    pfam00010
    Location:82135
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    89776332..89778754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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