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Gfpt2 glutamine fructose-6-phosphate transaminase 2 [ Mus musculus (house mouse) ]

Gene ID: 14584, updated on 18-Apr-2024

Summary

Official Symbol
Gfpt2provided by MGI
Official Full Name
glutamine fructose-6-phosphate transaminase 2provided by MGI
Primary source
MGI:MGI:1338883
See related
Ensembl:ENSMUSG00000020363 AllianceGenome:MGI:1338883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GFAT2
Summary
Predicted to enable glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Is expressed in craniocervical region bone; naris; and sternum. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GFPT2 (glutamine-fructose-6-phosphate transaminase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 15.4), subcutaneous fat pad adult (RPKM 9.9) and 19 other tissues See more
Orthologs
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Genomic context

Location:
11 B1.2; 11 29.9 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (49684981..49729448)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (49794155..49838620)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex, subunit 6 Neighboring gene STARR-positive B cell enhancer ABC_E9822 Neighboring gene predicted gene 12192 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:49538288-49538489 Neighboring gene predicted gene, 36411 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:49578193-49578302 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:49585761-49585914 Neighboring gene STARR-seq mESC enhancer starr_29382 Neighboring gene predicted gene, 36507 Neighboring gene STARR-seq mESC enhancer starr_29384 Neighboring gene STARR-positive B cell enhancer ABC_E5221 Neighboring gene mitogen-activated protein kinase 9 Neighboring gene predicted gene, 53699 Neighboring gene RasGEF domain family, member 1C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

General protein information

Preferred Names
glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
Names
D-fructose-6-phosphate amidotransferase 2
GFAT 2
glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2
glutamine:fructose-6-phosphate amidotransferase 2
hexosephosphate aminotransferase 2
NP_038557.1
XP_036012229.1
XP_036012230.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013529.3NP_038557.1  glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

    See identical proteins and their annotated locations for NP_038557.1

    Status: VALIDATED

    Source sequence(s)
    AK132821, BE198515, BM204562, CJ163487, DY247913
    Consensus CDS
    CCDS24622.1
    UniProtKB/Swiss-Prot
    Q5NCL2, Q9Z2Z9
    UniProtKB/TrEMBL
    Q3V0X4
    Related
    ENSMUSP00000020629.5, ENSMUST00000020629.5
    Conserved Domains (4) summary
    PLN02981
    Location:1682
    PLN02981; glucosamine:fructose-6-phosphate aminotransferase
    cd00714
    Location:2285
    GFAT; Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In ...
    cd05008
    Location:369494
    SIS_GlmS_GlmD_1; SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...
    cd05009
    Location:526680
    SIS_GlmS_GlmD_2; SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    49684981..49729448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156337.1XP_036012230.1  glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 isoform X2

    Conserved Domains (1) summary
    PLN02981
    Location:1428
    PLN02981; glucosamine:fructose-6-phosphate aminotransferase
  2. XM_036156336.1XP_036012229.1  glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 isoform X1

    UniProtKB/TrEMBL
    Q3V0X4
    Conserved Domains (1) summary
    PLN02981
    Location:2675
    PLN02981; glucosamine:fructose-6-phosphate aminotransferase