Format

Send to:

Choose Destination

PRIMA1 proline rich membrane anchor 1 [ Homo sapiens (human) ]

Gene ID: 145270, updated on 29-Mar-2020

Summary

Official Symbol
PRIMA1provided by HGNC
Official Full Name
proline rich membrane anchor 1provided by HGNC
Primary source
HGNC:HGNC:18319
See related
Ensembl:ENSG00000175785 MIM:613851
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRIMA
Summary
The product of this gene functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes. [provided by RefSeq, Nov 2008]
Expression
Broad expression in esophagus (RPKM 7.2), endometrium (RPKM 3.8) and 19 other tissues See more
Orthologs

Genomic context

See PRIMA1 in Genome Data Viewer
Location:
14q32.12
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (93718298..93789029, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94184644..94254766, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene unc-79 homolog, NALCN channel complex subunit Neighboring gene cytochrome c oxidase subunit 8C Neighboring gene RNA, U6 small nuclear 1258, pseudogene Neighboring gene uncharacterized LOC105370631 Neighboring gene FAM181A antisense RNA 1 Neighboring gene family with sequence similarity 181 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
neurotransmitter catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proline-rich membrane anchor 1
Names
acetylcholinesterase membrane anchor precursor PRiMA

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009069.1 RefSeqGene

    Range
    4936..75123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178013.4NP_821092.1  proline-rich membrane anchor 1 precursor

    See identical proteins and their annotated locations for NP_821092.1

    Status: REVIEWED

    Source sequence(s)
    AL132642, AL157858, AY225516, BU726715
    Consensus CDS
    CCDS9912.1
    UniProtKB/Swiss-Prot
    Q86XR5
    UniProtKB/TrEMBL
    A0A024R6J9
    Related
    ENSP00000376848.1, ENST00000393140.6
    Conserved Domains (1) summary
    pfam16101
    Location:37153
    PRIMA1; Proline-rich membrane anchor 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    93718298..93789029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536456.2XP_011534758.1  proline-rich membrane anchor 1 isoform X1

    See identical proteins and their annotated locations for XP_011534758.1

    UniProtKB/Swiss-Prot
    Q86XR5
    UniProtKB/TrEMBL
    A0A024R6J9
    Conserved Domains (1) summary
    pfam16101
    Location:37153
    PRIMA1; Proline-rich membrane anchor 1
  2. XM_024449482.1XP_024305250.1  proline-rich membrane anchor 1 isoform X2

    Related
    ENSP00000434370.1, ENST00000477603.5
    Conserved Domains (1) summary
    pfam16101
    Location:37119
    PRIMA1; Proline-rich membrane anchor 1

RNA

  1. XR_002957532.1 RNA Sequence

  2. XR_002957533.1 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187601.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    832860..903047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178004.1: Suppressed sequence

    Description
    NM_178004.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Support Center