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GSC goosecoid homeobox [ Homo sapiens (human) ]

Gene ID: 145258, updated on 5-Jul-2025
Official Symbol
GSCprovided by HGNC
Official Full Name
goosecoid homeoboxprovided by HGNC
Primary source
HGNC:HGNC:4612
See related
Ensembl:ENSG00000133937 MIM:138890; AllianceGenome:HGNC:4612
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GSC1; SAMS
Summary
This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in fat (RPKM 1.7), brain (RPKM 0.2) and 8 other tissues See more
Orthologs
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See GSC in Genome Data Viewer
Location:
14q32.13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (94768223..94770113, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (88998287..89000177, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (95234560..95236450, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 59 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:95147830-95148378 Neighboring gene ribosomal protein SA pseudogene 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_38793 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95234013-95234551 Neighboring gene GSC divergent transcript Neighboring gene ribosomal protein L15 pseudogene 2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
acts_upstream_of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within dorsal/ventral neural tube patterning IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ear development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within forebrain development IEA
Inferred from Electronic Annotation
more info
 
involved_in gastrulation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in middle ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in middle ear morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within muscle organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in neural crest cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within signal transduction involved in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in tissue development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
homeobox protein goosecoid

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034111.1 RefSeqGene

    Range
    5050..6940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173849.3NP_776248.1  homeobox protein goosecoid

    See identical proteins and their annotated locations for NP_776248.1

    Status: REVIEWED

    Source sequence(s)
    AY177407
    Consensus CDS
    CCDS9930.1
    UniProtKB/Swiss-Prot
    P56915, Q86YR1
    Related
    ENSP00000238558.3, ENST00000238558.5
    Conserved Domains (1) summary
    pfam00046
    Location:163216
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    94768223..94770113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    88998287..89000177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)