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GSC goosecoid homeobox [ Homo sapiens (human) ]

Gene ID: 145258, updated on 8-Dec-2018

Summary

Official Symbol
GSCprovided by HGNC
Official Full Name
goosecoid homeoboxprovided by HGNC
Primary source
HGNC:HGNC:4612
See related
Ensembl:ENSG00000133937 MIM:138890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAMS
Summary
This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in fat (RPKM 1.7), brain (RPKM 0.2) and 8 other tissues See more
Orthologs

Genomic context

See GSC in Genome Data Viewer
Location:
14q32.13
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (94768223..94770162, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (95234560..95236499, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 59 pseudogene Neighboring gene ribosomal protein SA pseudogene 4 Neighboring gene GSC divergent transcript Neighboring gene ribosomal protein L15 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
dorsal/ventral neural tube patterning IEA
Inferred from Electronic Annotation
more info
 
embryonic skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
gastrulation NAS
Non-traceable Author Statement
more info
PubMed 
middle ear morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
muscle organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
neural crest cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction involved in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034111.1 RefSeqGene

    Range
    5001..6940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173849.2NP_776248.1  homeobox protein goosecoid

    See identical proteins and their annotated locations for NP_776248.1

    Status: REVIEWED

    Source sequence(s)
    AY177407
    Consensus CDS
    CCDS9930.1
    UniProtKB/Swiss-Prot
    P56915
    Related
    ENSP00000238558.3, ENST00000238558.4
    Conserved Domains (1) summary
    pfam00046
    Location:163216
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    94768223..94770162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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