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Gbx2 gastrulation brain homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 14472, updated on 11-Dec-2018

Summary

Official Symbol
Gbx2provided by MGI
Official Full Name
gastrulation brain homeobox 2provided by MGI
Primary source
MGI:MGI:95668
See related
Ensembl:ENSMUSG00000034486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gbx-2; MMoxA; Stra7; D130058E05Rik
Expression
Biased expression in whole brain E14.5 (RPKM 10.0), CNS E14 (RPKM 6.9) and 5 other tissues See more
Orthologs

Genomic context

See Gbx2 in Genome Data Viewer
Location:
1 D; 1 45.06 cM
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (89927962..89931176, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (91824537..91827751, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 Neighboring gene predicted gene 28499 Neighboring gene predicted gene, 41914 Neighboring gene RIKEN cDNA 4933400F21 gene Neighboring gene uncharacterized LOC102637806 Neighboring gene predicted gene, 41915 Neighboring gene ankyrin repeat and SOCS box-containing 18 Neighboring gene predicted gene, 34616

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Dopaminergic Neurogenesis, organism-specific biosystem (from WikiPathways)
    Dopaminergic Neurogenesis, organism-specific biosystemhttps://www.michaeljfox.org/foundation/grant-detail.php?grant_id=141
  • PluriNetWork, organism-specific biosystem (from WikiPathways)
    PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
autonomic nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in blood vessel morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebellar granule cell precursor proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebellum development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hindbrain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hindbrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
midbrain-hindbrain boundary development IMP
Inferred from Mutant Phenotype
more info
PubMed 
midbrain-hindbrain boundary morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
rhombomere 2 development IMP
Inferred from Mutant Phenotype
more info
PubMed 
thalamus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeobox protein GBX-2
Names
gastrulation and brain-specific homeobox protein 2
stimulated by retinoic acid gene 7 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010262.3NP_034392.1  homeobox protein GBX-2

    See identical proteins and their annotated locations for NP_034392.1

    Status: VALIDATED

    Source sequence(s)
    AC124227
    Consensus CDS
    CCDS15150.1
    UniProtKB/Swiss-Prot
    P48031
    Related
    ENSMUSP00000048508.7, ENSMUST00000036954.8
    Conserved Domains (1) summary
    pfam00046
    Location:250303
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    89927962..89931176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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