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Gbp2 guanylate binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 14469, updated on 8-Feb-2024

Summary

Official Symbol
Gbp2provided by MGI
Official Full Name
guanylate binding protein 2provided by MGI
Primary source
MGI:MGI:102772
See related
Ensembl:ENSMUSG00000028270 AllianceGenome:MGI:102772
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including Hsp90 protein binding activity; cytoskeletal protein binding activity; and guanyl ribonucleotide binding activity. Acts upstream of or within several processes, including cellular response to interferon-beta; cellular response to lipopolysaccharide; and defense response to other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to several human genes including GBP2 (guanylate binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 40.7), subcutaneous fat pad adult (RPKM 15.6) and 13 other tissues See more
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Genomic context

See Gbp2 in Genome Data Viewer
Location:
3 H1; 3 66.69 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (142326424..142343769)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (142620663..142638008)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene guanylate binding protein 3 Neighboring gene predicted gene, 40158 Neighboring gene STARR-positive B cell enhancer ABC_E10218 Neighboring gene STARR-positive B cell enhancer mm9_chr3:142263123-142263423 Neighboring gene guanylate binding protein 2b Neighboring gene STARR-positive B cell enhancer mm9_chr3:142282846-142283147 Neighboring gene predicted gene, 54185 Neighboring gene microRNA 6381 Neighboring gene STARR-seq mESC enhancer starr_09157 Neighboring gene STARR-seq mESC enhancer starr_09159 Neighboring gene guanylate binding protein 2, pseudogene Neighboring gene human immunodeficiency virus type I enhancer binding protein 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables GTPase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables cytokine binding ISO
Inferred from Sequence Orthology
more info
 
enables endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adhesion of symbiont to host IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to interferon-beta IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to interferon-beta IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytolysis in another organism IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytolysis in another organism IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to protozoan IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within defense response to protozoan IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of AIM2 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of pyroptosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of pyroptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein targeting IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in symbiont cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in symbiont cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in symbiont-containing vacuole membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
guanylate-binding protein 2
Names
GBP-2
GTP-binding protein 2
guanine nucleotide-binding protein 2
guanylate nucleotide binding protein 2
guanylate-binding protein 1
interferon-induced guanylate-binding protein 2
mGBP-2
mGBP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010260.1NP_034390.1  guanylate-binding protein 2

    See identical proteins and their annotated locations for NP_034390.1

    Status: PROVISIONAL

    Source sequence(s)
    AF077007
    Consensus CDS
    CCDS17880.1
    UniProtKB/Swiss-Prot
    Q4FK03, Q8CIC6, Q921N2, Q9R1I0, Q9Z0E6
    UniProtKB/TrEMBL
    Q3UDC7
    Related
    ENSMUSP00000132435.2, ENSMUST00000165774.8
    Conserved Domains (3) summary
    pfam02841
    Location:282578
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:18280
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:288578
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    142326424..142343769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)