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Gata4 GATA binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 14463, updated on 2-Apr-2024

Summary

Official Symbol
Gata4provided by MGI
Official Full Name
GATA binding protein 4provided by MGI
Primary source
MGI:MGI:95664
See related
Ensembl:ENSMUSG00000021944 AllianceGenome:MGI:95664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gata-4
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including heart development; negative regulation of cell death; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and regulation of gene expression. Located in chromatin and nucleus. Is expressed in several structures, including early conceptus; embryo mesenchyme; gut; heart; and reproductive system. Used to study atrial heart septal defect 2 and congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 86.2), stomach adult (RPKM 63.9) and 5 other tissues See more
Orthologs
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Genomic context

See Gata4 in Genome Data Viewer
Location:
14 D1; 14 33.24 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (63436363..63509161, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (63198914..63271712, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene farnesyl diphosphate farnesyl transferase 1 Neighboring gene STARR-seq mESC enhancer starr_36919 Neighboring gene STARR-positive B cell enhancer ABC_E3119 Neighboring gene predicted gene, 53861 Neighboring gene nei like 2 (E. coli) Neighboring gene STARR-seq mESC enhancer starr_36921 Neighboring gene predicted gene 4151 Neighboring gene VISTA enhancer mm245 Neighboring gene predicted gene, 36165 Neighboring gene predicted gene, 46458

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables NFAT protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables co-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transcription coactivator binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Sertoli cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aortic valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in atrial septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in atrial septum primum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrial septum secundum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in atrioventricular canal development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in atrioventricular valve formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within atrioventricular valve morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in atrioventricular valve morphogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of cardiac muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cardiac muscle tissue regeneration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cardiac right ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac septum development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell-cell signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to follicle-stimulating hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to gonadotropin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in diaphragm morphogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within embryonic digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic foregut morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic heart tube anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocardial cushion development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in endocardial cushion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocardial cushion development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gastrulation with mouth forming second IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intestinal epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within lung lobe formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lung morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in male gonad development ISO
Inferred from Sequence Orthology
more info
 
involved_in mitral valve formation TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of connective tissue replacement IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in outflow tract morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of miRNA transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cardiac muscle cell contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to estrogen IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within seminiferous tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction involved in regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in skeletal muscle cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transdifferentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in tricuspid valve formation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within tube morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vasculogenesis involved in coronary vascular morphogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within ventricular cardiac muscle tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ventricular septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
transcription factor GATA-4
Names
GATA-binding factor 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310610.1NP_001297539.1  transcription factor GATA-4 isoform 1

    See identical proteins and their annotated locations for NP_001297539.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC090962, AK134639, BB044491
    Consensus CDS
    CCDS79331.1
    UniProtKB/TrEMBL
    E9PXW9, Q8VI87
    Related
    ENSMUSP00000066927.4, ENSMUST00000067417.10
    Conserved Domains (2) summary
    cd00202
    Location:270321
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:1204
    GATA-N; GATA-type transcription activator, N-terminal
  2. NM_008092.4NP_032118.2  transcription factor GATA-4 isoform 2

    See identical proteins and their annotated locations for NP_032118.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame donor splice site in the central coding region compared to variant 1. The encoded isoform (2) is one amino acid shorter than isoform 1.
    Source sequence(s)
    AC090962, AK134639, BB044491
    Consensus CDS
    CCDS49519.1
    UniProtKB/Swiss-Prot
    B9EHF7, P97491, Q08369, Q9QZK4
    UniProtKB/TrEMBL
    Q8VI87
    Related
    ENSMUSP00000113891.2, ENSMUST00000118022.8
    Conserved Domains (3) summary
    smart00401
    Location:267314
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:269320
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:1204
    GATA-N; GATA-type transcription activator, N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    63436363..63509161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244956.3XP_011243258.1  transcription factor GATA-4 isoform X1

    See identical proteins and their annotated locations for XP_011243258.1

    UniProtKB/TrEMBL
    E9PXW9, Q8VI87
    Conserved Domains (2) summary
    cd00202
    Location:270321
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:1204
    GATA-N; GATA-type transcription activator, N-terminal
  2. XM_011244957.3XP_011243259.1  transcription factor GATA-4 isoform X1

    See identical proteins and their annotated locations for XP_011243259.1

    UniProtKB/TrEMBL
    E9PXW9, Q8VI87
    Conserved Domains (2) summary
    cd00202
    Location:270321
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:1204
    GATA-N; GATA-type transcription activator, N-terminal