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Gart phosphoribosylglycinamide formyltransferase [ Mus musculus (house mouse) ]

Gene ID: 14450, updated on 2-Nov-2024

Summary

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Official Symbol
Gartprovided by MGI
Official Full Name
phosphoribosylglycinamide formyltransferaseprovided by MGI
Primary source
MGI:MGI:95654
See related
Ensembl:ENSMUSG00000022962 AllianceGenome:MGI:95654
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gaps; Prgs
Summary
Enables phosphoribosylamine-glycine ligase activity. Involved in purine ribonucleoside monophosphate biosynthetic process. Is active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 16.3), liver E14 (RPKM 16.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gart in Genome Data Viewer
Location:
16 C3.3; 16 53.18 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91418283..91444505, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91621395..91646972, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 50B Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:91588013-91588235 Neighboring gene STARR-positive B cell enhancer ABC_E3173 Neighboring gene STARR-positive B cell enhancer mm9_chr16:91619128-91619428 Neighboring gene DnaJ heat shock protein family (Hsp40) member C28 Neighboring gene STARR-positive B cell enhancer ABC_E3174 Neighboring gene STARR-positive B cell enhancer ABC_E7475 Neighboring gene predicted gene, 36712 Neighboring gene Son DNA binding protein Neighboring gene downstream neighbor of SON Neighboring gene STARR-positive B cell enhancer ABC_E2468

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tight binding of folate substrates and inhibitors to recombinant mouse glycinamide ribonucleotide formyltransferase. Sanghani SP, et al. Biochemistry, 1997 Aug 26. PMID 9265631
  2. Analysis of a mouse gene encoding three steps of purine synthesis reveals use of an intronic polyadenylation signal without alternative exon usage. Kan JL, et al. J Biol Chem, 1995 Jan 27. PMID 7829519
  3. Negative and positive cis-acting elements in the promoter of the mouse gene that encodes the serine/glycine-rich peptide core of secretory granule proteoglycans. Avraham S, et al. J Biol Chem, 1992 Jan 5. PMID 1730621
  4. Mouse cDNAs encoding a trifunctional protein of de novo purine synthesis and a related single-domain glycinamide ribonucleotide synthetase. Kan JL, et al. Gene, 1993 Dec 31. PMID 8299947
  5. Comparative gene mapping of human chromosome 21 and mouse chromosome 16. Cox DR, et al. Ann N Y Acad Sci, 1985. PMID 3160288

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylamine-glycine ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylamine-glycine ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoribosylamine-glycine ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphoribosylformylglycinamidine cyclo-ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylformylglycinamidine cyclo-ligase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables phosphoribosylglycinamide formyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' AMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 'de novo' AMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in 'de novo' IMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' IMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in 'de novo' XMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 'de novo' XMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in GMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in adenine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in brainstem development IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebellum development IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebral cortex development IEA
Inferred from Electronic Annotation
more info
  
involved_in glycine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in purine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tetrahydrofolate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
trifunctional purine biosynthetic protein adenosine-3
Names
glycinamide ribonucleotide synthetase
glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide formyltransferase
NP_001344280.1
NP_001412023.1
NP_001412024.1
NP_034386.2
XP_036015674.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357351.2 → NP_001344280.1  trifunctional purine biosynthetic protein adenosine-3

    Status: VALIDATED

    Source sequence(s)
    AC131691
    Consensus CDS
    CCDS28329.1
    UniProtKB/Swiss-Prot
    Q3TGI3, Q64737, Q6NS48
    UniProtKB/TrEMBL
    Q3UJP8
    Related
    ENSMUSP00000156002.2, ENSMUST00000232289.2
    Conserved Domains (3) summary
    cd08645
    Location:809 → 991
    FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
    PRK00885
    Location:4 → 427
    PRK00885; phosphoribosylamine--glycine ligase; Provisional
    PRK05385
    Location:435 → 766
    PRK05385; phosphoribosylaminoimidazole synthetase; Provisional

  2. NM_001425094.1 → NP_001412023.1  trifunctional purine biosynthetic protein adenosine-3

    Status: VALIDATED

    Source sequence(s)
    AC131691
    UniProtKB/Swiss-Prot
    Q3TGI3, Q64737, Q6NS48

  3. NM_001425095.1 → NP_001412024.1  trifunctional purine biosynthetic protein adenosine-3

    Status: VALIDATED

    Source sequence(s)
    AC131691
    UniProtKB/Swiss-Prot
    Q3TGI3, Q64737, Q6NS48

  4. NM_010256.3 → NP_034386.2  trifunctional purine biosynthetic protein adenosine-3

    See identical proteins and their annotated locations for NP_034386.2

    Status: VALIDATED

    Source sequence(s)
    AC131691
    Consensus CDS
    CCDS28329.1
    UniProtKB/Swiss-Prot
    Q3TGI3, Q64737, Q6NS48
    UniProtKB/TrEMBL
    Q3UJP8
    Related
    ENSMUSP00000023684.8, ENSMUST00000023684.14
    Conserved Domains (3) summary
    cd08645
    Location:809 → 991
    FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
    PRK00885
    Location:4 → 427
    PRK00885; phosphoribosylamine--glycine ligase; Provisional
    PRK05385
    Location:435 → 766
    PRK05385; phosphoribosylaminoimidazole synthetase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    91418283..91444505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159781.1 → XP_036015674.1  trifunctional purine biosynthetic protein adenosine-3 isoform X2

    Conserved Domains (2) summary
    PRK00885
    Location:4 → 427
    PRK00885; phosphoribosylamine--glycine ligase; Provisional
    PRK05385
    Location:435 → 703
    PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64737.3 GenPept UniProtKB/Swiss-Prot:Q64737

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