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SLC2A14 solute carrier family 2 member 14 [ Homo sapiens (human) ]

Gene ID: 144195, updated on 2-Nov-2024

Summary

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Official Symbol
SLC2A14provided by HGNC
Official Full Name
solute carrier family 2 member 14provided by HGNC
Primary source
HGNC:HGNC:18301
See related
Ensembl:ENSG00000173262 MIM:611039; AllianceGenome:HGNC:18301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUT14; SLC2A3P3
Summary
Members of the glucose transporter (GLUT) family, including SLC2A14, are highly conserved integral membrane proteins that transport hexoses such as glucose and fructose into all mammalian cells. GLUTs show tissue and cell-type specific expression (Wu and Freeze, 2002 [PubMed 12504846]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 31.0), bone marrow (RPKM 13.8) and 5 other tissues See more
Orthologs
all
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Genomic context

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See SLC2A14 in Genome Data Viewer
Location:
12p13.31
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (7812514..7891196, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (7827112..7905386, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7965110..8043792, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7918923-7919522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7919523-7920122 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:7924892-7925059 Neighboring gene NANOG neighbor homeobox Neighboring gene NANOG 5' regulatory region Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:7950942-7951507 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7951508-7952074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7954393-7954894 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:7957389-7957910 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:7957911-7958430 Neighboring gene Nanog homeobox Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4204 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:7960397-7960896 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7978921-7979457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7986285-7986785 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7991923-7992596 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7994866-7995750 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:8003712-8004911 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8012389-8013184 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8013185-8013979 Neighboring gene MPRA-validated peak1563 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:8016225-8016726 Neighboring gene ribosomal protein S20 pseudogene 29 Neighboring gene myosin light chain 9 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8025026-8025706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8033506-8034091 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8034092-8034676 Neighboring gene Sharpr-MPRA regulatory region 8483 Neighboring gene Nanog homeobox pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:8057929-8058458 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8060583-8061114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8062177-8062706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:8065488-8066477 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:8086891-8087844 Neighboring gene solute carrier family 2 member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GLUT14, a duplicon of GLUT3, is specifically expressed in testis as alternative splice forms. Wu X, et al. Genomics, 2002 Dec. PMID 12504846
  2. Genetic association of SLC2A14 polymorphism with Alzheimer's disease in a Han Chinese population. Wang W, et al. J Mol Neurosci, 2012 Jul. PMID 22421804
  3. The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease. Amir Shaghaghi M, et al. Am J Clin Nutr, 2017 Dec. PMID 28971850, Free PMC Article
  4. The SLC2A14 gene: genomic locus, tissue expression, splice variants, and subcellular localization of the protein. Amir Shaghaghi M, et al. Biochem Cell Biol, 2016 Aug. PMID 27460888
  5. Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism. Valli A, et al. Mol Cancer Res, 2019 Jul. PMID 30885992

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Under hypoxia and HIF1 blockade, cancer cells adapt their energy metabolism via upregulation of the GLUT14 glucose transporter and creatine metabolism providing new avenues for drug targeting.
    Title: Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism.
  2. Three alleles in the SLC2A14 gene associated independently with inflammatory bowel disease.
    Title: The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease.
  3. report presents an expanded SLC2A14 gene locus and a more diverse tissue expression, concurring with the existing evidence for disease associations
    Title: The SLC2A14 gene: genomic locus, tissue expression, splice variants, and subcellular localization of the protein.
  4. High expression of GLUT-14 was associated with Gastric Adenocarcinoma.
    Title: Both GLUT-1 and GLUT-14 are Independent Prognostic Factors in Gastric Adenocarcinoma.
  5. SLC2A14 polymorphism has a possible role in changing the genetic susceptibility to late Alzheimer disease age of onset in a Han Chinese population.
    Title: Genetic association of SLC2A14 polymorphism with Alzheimer's disease in a Han Chinese population.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp564K1672

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dehydroascorbic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in D-glucose import IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in D-glucose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in dehydroascorbic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dehydroascorbic acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in aggresome IDA
Inferred from Direct Assay
more info
  
located_in nucleus HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
solute carrier family 2, facilitated glucose transporter member 14
Names
glucose transporter type 14
solute carrier family 2 (facilitated glucose transporter), member 14
solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286233.2 → NP_001273162.1  solute carrier family 2, facilitated glucose transporter member 14 isoform a

    See identical proteins and their annotated locations for NP_001273162.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC006517, AK126026, AY357941, BC060766, DB061127, DB062960, DB069339, DB082816
    Consensus CDS
    CCDS8585.1
    UniProtKB/Swiss-Prot
    B3KVB5, B3KWW7, B7Z844, B7ZAC3, Q6UY84, Q8TDB8, Q8TDB9
    UniProtKB/TrEMBL
    B7Z5J8
    Related
    ENSP00000440480.1, ENST00000543909.5
    Conserved Domains (2) summary
    cd06174
    Location:38 → 472
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:39 → 489
    Sugar_tr; Sugar (and other) transporter

  2. NM_001286234.2 → NP_001273163.1  solute carrier family 2, facilitated glucose transporter member 14 isoform b

    See identical proteins and their annotated locations for NP_001273163.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AC006517, AY357941, BC060766, DB069339, DB082816
    Consensus CDS
    CCDS66301.1
    UniProtKB/TrEMBL
    B7Z5J8
    Related
    ENSP00000407287.2, ENST00000431042.7
    Conserved Domains (1) summary
    cd17431
    Location:13 → 457
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

  3. NM_001286235.2 → NP_001273164.1  solute carrier family 2, facilitated glucose transporter member 14 isoform b

    See identical proteins and their annotated locations for NP_001273164.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AC006517, AK122783, AY357941, BC060766, BG717327, DB069339, DB082816
    Consensus CDS
    CCDS66301.1
    UniProtKB/TrEMBL
    B7Z5J8
    Related
    ENSP00000340450.5, ENST00000340749.9
    Conserved Domains (1) summary
    cd17431
    Location:13 → 457
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

  4. NM_001286236.2 → NP_001273165.1  solute carrier family 2, facilitated glucose transporter member 14 isoform c

    See identical proteins and their annotated locations for NP_001273165.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at an alternate downstream start codon. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC006517, AK302881, AY357941, BC060766, DB069339, DB082816
    Consensus CDS
    CCDS66300.1
    UniProtKB/TrEMBL
    B7Z5A7
    Related
    ENSP00000440492.1, ENST00000535295.5
    Conserved Domains (2) summary
    cd06174
    Location:5 → 363
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:5 → 380
    Sugar_tr; Sugar (and other) transporter

  5. NM_001286237.2 → NP_001273166.1  solute carrier family 2, facilitated glucose transporter member 14 isoform d

    See identical proteins and their annotated locations for NP_001273166.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AC006517, AC007536
    Consensus CDS
    CCDS66302.1
    UniProtKB/TrEMBL
    B7Z5J8
    Related
    ENSP00000445929.1, ENST00000539924.5
    Conserved Domains (2) summary
    cd06174
    Location:53 → 487
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:54 → 504
    Sugar_tr; Sugar (and other) transporter

  6. NM_153449.4 → NP_703150.1  solute carrier family 2, facilitated glucose transporter member 14 isoform a

    See identical proteins and their annotated locations for NP_703150.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC006517, AF481879, AY357941, BC060766, DB069339
    Consensus CDS
    CCDS8585.1
    UniProtKB/Swiss-Prot
    B3KVB5, B3KWW7, B7Z844, B7ZAC3, Q6UY84, Q8TDB8, Q8TDB9
    UniProtKB/TrEMBL
    B7Z5J8
    Related
    ENSP00000379834.2, ENST00000396589.6
    Conserved Domains (2) summary
    cd06174
    Location:38 → 472
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:39 → 489
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    7812514..7891196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    7827112..7905386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TDB8.1 GenPept UniProtKB/Swiss-Prot:Q8TDB8

Gene LinkOut

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