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SLC2A14 solute carrier family 2 member 14 [ Homo sapiens (human) ]

Gene ID: 144195, updated on 16-Oct-2021

Summary

Official Symbol
SLC2A14provided by HGNC
Official Full Name
solute carrier family 2 member 14provided by HGNC
Primary source
HGNC:HGNC:18301
See related
Ensembl:ENSG00000173262 MIM:611039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUT14; SLC2A3P3
Summary
Members of the glucose transporter (GLUT) family, including SLC2A14, are highly conserved integral membrane proteins that transport hexoses such as glucose and fructose into all mammalian cells. GLUTs show tissue and cell-type specific expression (Wu and Freeze, 2002 [PubMed 12504846]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 31.0), bone marrow (RPKM 13.8) and 5 other tissues See more
Orthologs
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Genomic context

See SLC2A14 in Genome Data Viewer
Location:
12p13.31
Exon count:
21
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (7812514..7891196, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7965110..8043792, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NANOG neighbor homeobox Neighboring gene NANOG 5' regulatory region Neighboring gene Nanog homeobox Neighboring gene ribosomal protein S20 pseudogene 29 Neighboring gene myosin light chain 9 pseudogene Neighboring gene Nanog homeobox pseudogene 1 Neighboring gene solute carrier family 2 member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564K1672

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in dehydroascorbic acid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 14
Names
glucose transporter type 14
solute carrier family 2 (facilitated glucose transporter), member 14
solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286233.2NP_001273162.1  solute carrier family 2, facilitated glucose transporter member 14 isoform a

    See identical proteins and their annotated locations for NP_001273162.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC006517, AK126026, AY357941, BC060766, DB061127, DB062960, DB069339, DB082816
    Consensus CDS
    CCDS8585.1
    UniProtKB/Swiss-Prot
    Q8TDB8
    Related
    ENSP00000440480.1, ENST00000543909.5
    Conserved Domains (2) summary
    cd06174
    Location:38472
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:39489
    Sugar_tr; Sugar (and other) transporter
  2. NM_001286234.2NP_001273163.1  solute carrier family 2, facilitated glucose transporter member 14 isoform b

    See identical proteins and their annotated locations for NP_001273163.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AC006517, AY357941, BC060766, DB069339, DB082816
    Consensus CDS
    CCDS66301.1
    UniProtKB/Swiss-Prot
    Q8TDB8
    Related
    ENSP00000407287.2, ENST00000431042.7
    Conserved Domains (1) summary
    cd17431
    Location:13457
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  3. NM_001286235.2NP_001273164.1  solute carrier family 2, facilitated glucose transporter member 14 isoform b

    See identical proteins and their annotated locations for NP_001273164.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AC006517, AK122783, AY357941, BC060766, BG717327, DB069339, DB082816
    Consensus CDS
    CCDS66301.1
    UniProtKB/Swiss-Prot
    Q8TDB8
    Related
    ENSP00000340450.5, ENST00000340749.9
    Conserved Domains (1) summary
    cd17431
    Location:13457
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  4. NM_001286236.2NP_001273165.1  solute carrier family 2, facilitated glucose transporter member 14 isoform c

    See identical proteins and their annotated locations for NP_001273165.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at an alternate downstream start codon. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC006517, AK302881, AY357941, BC060766, DB069339, DB082816
    Consensus CDS
    CCDS66300.1
    UniProtKB/Swiss-Prot
    Q8TDB8
    Related
    ENSP00000440492.1, ENST00000535295.5
    Conserved Domains (2) summary
    cd06174
    Location:5363
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:5380
    Sugar_tr; Sugar (and other) transporter
  5. NM_001286237.2NP_001273166.1  solute carrier family 2, facilitated glucose transporter member 14 isoform d

    See identical proteins and their annotated locations for NP_001273166.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AC006517, AC007536
    Consensus CDS
    CCDS66302.1
    UniProtKB/Swiss-Prot
    Q8TDB8
    Related
    ENSP00000445929.1, ENST00000539924.5
    Conserved Domains (2) summary
    cd06174
    Location:53487
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:54504
    Sugar_tr; Sugar (and other) transporter
  6. NM_153449.4NP_703150.1  solute carrier family 2, facilitated glucose transporter member 14 isoform a

    See identical proteins and their annotated locations for NP_703150.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC006517, AF481879, AY357941, BC060766, DB069339
    Consensus CDS
    CCDS8585.1
    UniProtKB/Swiss-Prot
    Q8TDB8
    Related
    ENSP00000379834.2, ENST00000396589.6
    Conserved Domains (2) summary
    cd06174
    Location:38472
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:39489
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    7812514..7891196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018847.1XP_016874336.1  solute carrier family 2, facilitated glucose transporter member 14 isoform X2

    UniProtKB/Swiss-Prot
    Q8TDB8
    Conserved Domains (1) summary
    cd17431
    Location:13457
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  2. XM_017018845.2XP_016874334.1  solute carrier family 2, facilitated glucose transporter member 14 isoform X1

    Conserved Domains (1) summary
    cd17431
    Location:37481
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  3. XM_005253317.5XP_005253374.1  solute carrier family 2, facilitated glucose transporter member 14 isoform X2

    See identical proteins and their annotated locations for XP_005253374.1

    UniProtKB/Swiss-Prot
    Q8TDB8
    Conserved Domains (1) summary
    cd17431
    Location:13457
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  4. XM_005253315.4XP_005253372.1  solute carrier family 2, facilitated glucose transporter member 14 isoform X2

    See identical proteins and their annotated locations for XP_005253372.1

    UniProtKB/Swiss-Prot
    Q8TDB8
    Conserved Domains (1) summary
    cd17431
    Location:13457
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  5. XM_017018844.1XP_016874333.1  solute carrier family 2, facilitated glucose transporter member 14 isoform X1

    Conserved Domains (1) summary
    cd17431
    Location:37481
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  6. XM_017018841.1XP_016874330.1  solute carrier family 2, facilitated glucose transporter member 14 isoform X1

    Conserved Domains (1) summary
    cd17431
    Location:37481
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  7. XM_017018846.1XP_016874335.1  solute carrier family 2, facilitated glucose transporter member 14 isoform X2

    UniProtKB/Swiss-Prot
    Q8TDB8
    Conserved Domains (1) summary
    cd17431
    Location:13457
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  8. XM_011520562.1XP_011518864.1  solute carrier family 2, facilitated glucose transporter member 14 isoform X2

    See identical proteins and their annotated locations for XP_011518864.1

    UniProtKB/Swiss-Prot
    Q8TDB8
    Conserved Domains (1) summary
    cd17431
    Location:13457
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  9. XM_011520563.2XP_011518865.1  solute carrier family 2, facilitated glucose transporter member 14 isoform X2

    See identical proteins and their annotated locations for XP_011518865.1

    UniProtKB/Swiss-Prot
    Q8TDB8
    Conserved Domains (1) summary
    cd17431
    Location:13457
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  10. XM_024448849.1XP_024304617.1  solute carrier family 2, facilitated glucose transporter member 14 isoform X2

    Conserved Domains (1) summary
    cd17431
    Location:13457
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  11. XM_024448848.1XP_024304616.1  solute carrier family 2, facilitated glucose transporter member 14 isoform X1

    Conserved Domains (1) summary
    cd17431
    Location:37481
    MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
  12. XM_011520565.2XP_011518867.1  solute carrier family 2, facilitated glucose transporter member 14 isoform X3

    See identical proteins and their annotated locations for XP_011518867.1

    UniProtKB/Swiss-Prot
    Q8TDB8
    Conserved Domains (2) summary
    cd06174
    Location:5363
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:5380
    Sugar_tr; Sugar (and other) transporter
  13. XM_011520564.2XP_011518866.1  solute carrier family 2, facilitated glucose transporter member 14 isoform X3

    See identical proteins and their annotated locations for XP_011518866.1

    UniProtKB/Swiss-Prot
    Q8TDB8
    Conserved Domains (2) summary
    cd06174
    Location:5363
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:5380
    Sugar_tr; Sugar (and other) transporter
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