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TMEM86A transmembrane protein 86A [ Homo sapiens (human) ]

Gene ID: 144110, updated on 22-Sep-2022

Summary

Official Symbol
TMEM86Aprovided by HGNC
Official Full Name
transmembrane protein 86Aprovided by HGNC
Primary source
HGNC:HGNC:26890
See related
Ensembl:ENSG00000151117 AllianceGenome:HGNC:26890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable alkenylglycerophosphocholine hydrolase activity and alkenylglycerophosphoethanolamine hydrolase activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 12.8), skin (RPKM 8.6) and 23 other tissues See more
Orthologs
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Genomic context

See TMEM86A in Genome Data Viewer
Location:
11p15.1
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (18698779..18709107)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (18796841..18802847)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18720326..18726332)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376578 Neighboring gene SRSF3 pseudogene 1 Neighboring gene immunoglobulin superfamily member 22 Neighboring gene protein tyrosine phosphatase non-receptor type 5 Neighboring gene Sharpr-MPRA regulatory region 5421 Neighboring gene MAS related GPR family member X8, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90119

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alkenylglycerophosphocholine hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alkenylglycerophosphoethanolamine hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lysoplasmalogenase-like protein TMEM86A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153347.3NP_699178.1  lysoplasmalogenase-like protein TMEM86A

    See identical proteins and their annotated locations for NP_699178.1

    Status: VALIDATED

    Source sequence(s)
    AC103974
    Consensus CDS
    CCDS7844.1
    UniProtKB/Swiss-Prot
    Q8N2M4, Q96AJ0
    Related
    ENSP00000280734.2, ENST00000280734.3
    Conserved Domains (1) summary
    pfam07947
    Location:37224
    YhhN; YhhN-like protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    18698779..18709107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426448.1XP_047282404.1  lysoplasmalogenase-like protein TMEM86A isoform X1

    UniProtKB/Swiss-Prot
    Q96AJ0
  2. XM_047426449.1XP_047282405.1  lysoplasmalogenase-like protein TMEM86A isoform X1

    UniProtKB/Swiss-Prot
    Q96AJ0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    18796841..18802847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)