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Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 [ Mus musculus (house mouse) ]

Gene ID: 14375, updated on 8-Feb-2024

Summary

Official Symbol
Xrcc6provided by MGI
Official Full Name
X-ray repair complementing defective repair in Chinese hamster cells 6provided by MGI
Primary source
MGI:MGI:95606
See related
Ensembl:ENSMUSG00000022471 AllianceGenome:MGI:95606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ku70; 70kDa; G22p1
Summary
Enables double-stranded DNA binding activity. Involved in positive regulation of lymphocyte differentiation. Acts upstream of or within DNA metabolic process; positive regulation of neurogenesis; and response to ionizing radiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; early conceptus; gonad; liver lobe; and telencephalon ventricular layer. Orthologous to human XRCC6 (X-ray repair cross complementing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 14.8), liver E14 (RPKM 4.4) and 23 other tissues See more
Orthologs
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Genomic context

See Xrcc6 in Genome Data Viewer
Location:
15 E1; 15 38.33 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81868805..81924286)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81987833..82040085)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S14 Neighboring gene NADH:ubiquinone oxidoreductase subunit B11B Neighboring gene desumoylating isopeptidase 1 Neighboring gene STARR-positive B cell enhancer ABC_E7400 Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) Neighboring gene RIKEN cDNA 4930407I10 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-deoxyribose-5-phosphate lyase activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP-dependent activity, acting on DNA ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA end binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
 
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to double-stranded telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables telomeric DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within V(D)J recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular hyperosmotic salinity response ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to X-ray ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair via classical nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair via nonhomologous end joining NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lymphocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in recombinational repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of DNA-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
part_of DNA-dependent protein kinase-DNA ligase 4 complex ISO
Inferred from Sequence Orthology
more info
 
part_of Ku70:Ku80 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Ku70:Ku80 complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of nonhomologous end joining complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
X-ray repair cross-complementing protein 6
Names
5'-dRP/AP lyase Ku70
5'-deoxyribose-5-phosphate lyase Ku70
ATP-dependent DNA helicase 2 subunit 1
ATP-dependent DNA helicase II 70 kDa subunit
CTC box-binding factor 75 kDa subunit
CTC75
CTCBF
DNA repair protein XRCC6
Ku p70
ku autoantigen protein p70 homolog
thyroid autoantigen 70 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411249.1NP_001398178.1  X-ray repair cross-complementing protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC102176
    UniProtKB/Swiss-Prot
    O88212, P23475, Q3UJL8, Q62027, Q62382, Q62453, Q6GTV8, Q8QZX7
    UniProtKB/TrEMBL
    A0A0R4J187
    Related
    ENSMUSP00000097968.5, ENSMUST00000100399.11
  2. NM_001411250.1NP_001398179.1  X-ray repair cross-complementing protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102176
  3. NM_010247.3NP_034377.2  X-ray repair cross-complementing protein 6 isoform 1

    See identical proteins and their annotated locations for NP_034377.2

    Status: VALIDATED

    Source sequence(s)
    AC102176
    Consensus CDS
    CCDS37153.1
    UniProtKB/Swiss-Prot
    O88212, P23475, Q3UJL8, Q62027, Q62382, Q62453, Q6GTV8, Q8QZX7
    UniProtKB/TrEMBL
    A0A0R4J187
    Related
    ENSMUSP00000068559.7, ENSMUST00000069530.13
    Conserved Domains (1) summary
    TIGR00578
    Location:22606
    ku70; ATP-dependent DNA helicase II, 70 kDa subunit (ku70)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    81868805..81924286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245456.4XP_011243758.1  X-ray repair cross-complementing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011243758.1

    UniProtKB/Swiss-Prot
    O88212, P23475, Q3UJL8, Q62027, Q62382, Q62453, Q6GTV8, Q8QZX7
    UniProtKB/TrEMBL
    A0A0R4J187
    Conserved Domains (1) summary
    TIGR00578
    Location:22606
    ku70; ATP-dependent DNA helicase II, 70 kDa subunit (ku70)
  2. XM_006520442.5XP_006520505.1  X-ray repair cross-complementing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006520505.1

    UniProtKB/Swiss-Prot
    O88212, P23475, Q3UJL8, Q62027, Q62382, Q62453, Q6GTV8, Q8QZX7
    UniProtKB/TrEMBL
    A0A0R4J187
    Conserved Domains (1) summary
    TIGR00578
    Location:22606
    ku70; ATP-dependent DNA helicase II, 70 kDa subunit (ku70)
  3. XM_006520444.2XP_006520507.1  X-ray repair cross-complementing protein 6 isoform X2

    UniProtKB/Swiss-Prot
    O88212, P23475, Q3UJL8, Q62027, Q62382, Q62453, Q6GTV8, Q8QZX7
    Conserved Domains (1) summary
    TIGR00578
    Location:51593
    ku70; ATP-dependent DNA helicase II, 70 kDa subunit (ku70)

RNA

  1. XR_383982.4 RNA Sequence