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SESN3 sestrin 3 [ Homo sapiens (human) ]

Gene ID: 143686, updated on 2-Nov-2024

Summary

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Official Symbol
SESN3provided by HGNC
Official Full Name
sestrin 3provided by HGNC
Primary source
HGNC:HGNC:23060
See related
Ensembl:ENSG00000149212 MIM:607768; AllianceGenome:HGNC:23060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEST3
Summary
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in brain (RPKM 14.9), lymph node (RPKM 14.4) and 24 other tissues See more
Orthologs
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Genomic context

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See SESN3 in Genome Data Viewer
Location:
11q21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (95165513..95232475, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (95172632..95239638, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (94898677..94965639, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr11.4868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:94883489-94884030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:94884031-94884572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3847 Neighboring gene lncRNA imatinib upregulated Neighboring gene BUD13 homolog pseudogene 1 Neighboring gene uncharacterized LOC100129203 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3848 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3849 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:94964745-94965384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:94965385-94966024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:94981794-94982294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5416 Neighboring gene Sharpr-MPRA regulatory region 282 Neighboring gene VISTA enhancer hs2531 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:95074595-95075094 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:95092304-95093503 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:95180437-95180967 Neighboring gene uncharacterized LOC105369439 Neighboring gene MPRA-validated peak1408 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr11:95209557-95210058 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:95215468-95216018 Neighboring gene uncharacterized LOC105369440

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inhibition of nucleo-cytoplasmic proteasome translocation by the aromatic amino acids or silencing Sestrin3-their sensing mediator-is tumor suppressive. Livneh I, et al. Cell Death Differ, 2024 Oct. PMID 39266717, Free PMC Article
  2. Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability. Kopnin PB, et al. Cancer Res, 2007 May 15. PMID 17510393, Free PMC Article
  3. Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells. Vakana E, et al. PLoS One, 2013. PMID 24260131, Free PMC Article
  4. Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle. Nascimento EB, et al. Am J Physiol Endocrinol Metab, 2013 Dec 1. PMID 24129397, Free PMC Article
  5. Prediction and Validation of Transcription Factors Modulating the Expression of Sestrin3 Gene Using an Integrated Computational and Experimental Approach. Srivastava R, et al. PLoS One, 2016. PMID 27466818, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of nucleo-cytoplasmic proteasome translocation by the aromatic amino acids or silencing Sestrin3-their sensing mediator-is tumor suppressive.
    Title: Inhibition of nucleo-cytoplasmic proteasome translocation by the aromatic amino acids or silencing Sestrin3-their sensing mediator-is tumor suppressive.
  2. Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development of new-onset diabetes after kidney transplantation.
    Title: Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development of new-onset diabetes after kidney transplantation.
  3. The functions and roles of sestrins in regulating human diseases.
    Title: The functions and roles of sestrins in regulating human diseases.
  4. Oncogenic role of early growth response-1 in liver cancer through the regulation of the microRNA-675/sestrin 3 and the Wnt/beta-catenin signaling pathway.
    Title: Oncogenic role of early growth response-1 in liver cancer through the regulation of the microRNA-675/sestrin 3 and the Wnt/β-catenin signaling pathway.
  5. Colon and liver tissue damage detection using methylated SESN3 and PTK2B genes in circulating cell-free DNA in patients with acute graft-versus-host disease.
    Title: Colon and liver tissue damage detection using methylated SESN3 and PTK2B genes in circulating cell-free DNA in patients with acute graft-versus-host disease.
  6. Circulating Sestrin Levels Are Increased in Hypertension Patients.
    Title: Circulating Sestrin Levels Are Increased in Hypertension Patients.
  7. identified new interactions between miR-200 and the oxidative stress response SESN proteins that affect anoikis resistance in human endometrial cancer cells.
    Title: Interactions between microRNA-200 family and Sestrin proteins in endometrial cancer cell lines and their significance to anoikis.
  8. It is possible that the over expression of the SESN3 gene, known to suppress oxidative damage, may have contributed to the attenuation of fatigue in Puerto Rican Men during Radiotherapy for Prostate Cancer
    Title: Gene Expression, and Fatigue in Puerto Rican Men during Radiotherapy for Prostate Cancer: an Exploratory Study.
  9. Results suggest that Sesn3 is a target gene for rno-miR-155. Moreover, the rno-miR-155 antagonist may induce the expression of Sesn3, and then indirectly decrease the damage of oxidative stress to protect the brain from epileptogenesis-associated impairments.
    Title: Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiological features and cell apoptosis by activating Sestrin-3.
  10. The expression of SESN3 and (TSC2 and FOXO1) was identified in Lewy bodies from brainstem.
    Title: Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC29667

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-leucine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on peroxide as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in TORC2 signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to L-leucine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to leucine starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of response to reactive oxygen species IEA
Inferred from Electronic Annotation
more info
  
involved_in response to insulin IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GATOR2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TORC2 complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sestrin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271594.2 → NP_001258523.1  sestrin-3 isoform 2

    See identical proteins and their annotated locations for NP_001258523.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site compared to variant 1. It encodes a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AK302366, AP000787
    Consensus CDS
    CCDS60938.1
    UniProtKB/Swiss-Prot
    P58005
    Related
    ENSP00000278499.2, ENST00000278499.6
    Conserved Domains (1) summary
    pfam04636
    Location:1 → 351
    PA26; PA26 p53-induced protein (sestrin)

  2. NM_144665.4 → NP_653266.2  sestrin-3 isoform 1

    See identical proteins and their annotated locations for NP_653266.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF086251, AK096300, AP000787
    Consensus CDS
    CCDS8303.1
    UniProtKB/Swiss-Prot
    B7Z7P9, P58005, Q96AD1
    Related
    ENSP00000441927.1, ENST00000536441.7
    Conserved Domains (1) summary
    pfam04636
    Location:39 → 490
    PA26; PA26 p53-induced protein (sestrin)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    95165513..95232475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542614.2 → XP_011540916.1  sestrin-3 isoform X1

    Conserved Domains (1) summary
    pfam04636
    Location:16 → 467
    PA26; PA26 p53-induced protein (sestrin)

  2. XM_024448355.2 → XP_024304123.1  sestrin-3 isoform X2

    Conserved Domains (1) summary
    pfam04636
    Location:1 → 412
    PA26; PA26 p53-induced protein (sestrin)

  3. XM_047426416.1 → XP_047282372.1  sestrin-3 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    95172632..95239638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367754.1 → XP_054223729.1  sestrin-3 isoform X1

  2. XM_054367755.1 → XP_054223730.1  sestrin-3 isoform X2

  3. XM_054367756.1 → XP_054223731.1  sestrin-3 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58005.2 GenPept UniProtKB/Swiss-Prot:P58005

Gene LinkOut

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