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SESN3 sestrin 3 [ Homo sapiens (human) ]

Gene ID: 143686, updated on 12-Oct-2019

Summary

Official Symbol
SESN3provided by HGNC
Official Full Name
sestrin 3provided by HGNC
Primary source
HGNC:HGNC:23060
See related
Ensembl:ENSG00000149212 MIM:607768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEST3
Summary
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in brain (RPKM 14.9), lymph node (RPKM 14.4) and 24 other tissues See more
Orthologs

Genomic context

See SESN3 in Genome Data Viewer
Location:
11q21
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (95165513..95232536, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (94898677..94965705, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929295 Neighboring gene BUD13 homolog pseudogene 1 Neighboring gene uncharacterized LOC100129203 Neighboring gene VISTA enhancer hs2531 Neighboring gene uncharacterized LOC105369439

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
    Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystemThe hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated ...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Longevity regulating pathway, organism-specific biosystem (from KEGG)
    Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
  • TP53 Regulates Metabolic Genes, organism-specific biosystem (from REACTOME)
    TP53 Regulates Metabolic Genes, organism-specific biosystemWhile the p53 tumor suppressor protein (TP53) is known to inhibit cell growth by inducing apoptosis, senescence and cell cycle arrest, recent studies have found that p53 is also able to influence cel...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC29667

Gene Ontology Provided by GOA

Function Evidence Code Pubs
leucine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidoreductase activity, acting on peroxide as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
TORC2 signaling IEA
Inferred from Electronic Annotation
more info
 
cellular response to amino acid starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to amino acid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to leucine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to leucine starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of response to reactive oxygen species IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with GATOR2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with GATOR2 complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271594.2NP_001258523.1  sestrin-3 isoform 2

    See identical proteins and their annotated locations for NP_001258523.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site compared to variant 1. It encodes a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AK302366, AP000787
    Consensus CDS
    CCDS60938.1
    UniProtKB/Swiss-Prot
    P58005
    Related
    ENSP00000278499.2, ENST00000278499.6
    Conserved Domains (1) summary
    pfam04636
    Location:1351
    PA26; PA26 p53-induced protein (sestrin)
  2. NM_144665.4NP_653266.2  sestrin-3 isoform 1

    See identical proteins and their annotated locations for NP_653266.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF086251, AK096300, AP000787
    Consensus CDS
    CCDS8303.1
    UniProtKB/Swiss-Prot
    P58005
    Related
    ENSP00000441927.1, ENST00000536441.7
    Conserved Domains (1) summary
    pfam04636
    Location:39490
    PA26; PA26 p53-induced protein (sestrin)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    95165513..95232536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448355.1XP_024304123.1  sestrin-3 isoform X2

    Conserved Domains (1) summary
    pfam04636
    Location:1412
    PA26; PA26 p53-induced protein (sestrin)
  2. XM_011542614.1XP_011540916.1  sestrin-3 isoform X1

    Conserved Domains (1) summary
    pfam04636
    Location:16467
    PA26; PA26 p53-induced protein (sestrin)
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