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ITLN2 intelectin 2 [ Homo sapiens (human) ]

Gene ID: 142683, updated on 23-Nov-2023

Summary

Official Symbol
ITLN2provided by HGNC
Official Full Name
intelectin 2provided by HGNC
Primary source
HGNC:HGNC:20599
See related
Ensembl:ENSG00000158764 MIM:609874; AllianceGenome:HGNC:20599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HL2; HL-2
Summary
Predicted to enable oligosaccharide binding activity. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine (RPKM 141.3), duodenum (RPKM 79.7) and 1 other tissue See more
Orthologs
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Genomic context

See ITLN2 in Genome Data Viewer
Location:
1q23.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (160945025..160954809, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160082115..160094468, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (160914815..160924599, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene spermine synthase pseudogene Neighboring gene Sharpr-MPRA regulatory region 12849 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:160882532-160883186 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:160883187-160883841 Neighboring gene MPRA-validated peak433 silencer Neighboring gene uncharacterized LOC124904441 Neighboring gene uncharacterized LOC101928372 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:160931121-160931639 Neighboring gene Sharpr-MPRA regulatory region 3396 Neighboring gene Sharpr-MPRA regulatory region 578 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:160960931-160961769 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:160975781-160976290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:160976291-160976800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:160976801-160977309 Neighboring gene F11 receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:160985695-160986292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1969 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:160991075-160991672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161002153-161003089 Neighboring gene GLR5 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oligosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
intelectin-2
Names
endothelial lectin HL-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080878.3NP_543154.1  intelectin-2 precursor

    See identical proteins and their annotated locations for NP_543154.1

    Status: VALIDATED

    Source sequence(s)
    AL354714, AL591806, AY358905
    Consensus CDS
    CCDS1212.1
    UniProtKB/Swiss-Prot
    Q17RR2, Q5VYI0, Q8WWU7
    Related
    ENSP00000357008.3, ENST00000368029.4
    Conserved Domains (1) summary
    cl00085
    Location:4994
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    160945025..160954809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453321.2XP_024309089.1  intelectin-2 isoform X1

    Conserved Domains (1) summary
    cl00085
    Location:4893
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    160082115..160094468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334534.1XP_054190509.1  intelectin-2 isoform X2

  2. XM_054334535.1XP_054190510.1  intelectin-2 isoform X1