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Fmo1 flavin containing monooxygenase 1 [ Mus musculus (house mouse) ]

Gene ID: 14261, updated on 2-Nov-2024

Summary

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Official Symbol
Fmo1provided by MGI
Official Full Name
flavin containing monooxygenase 1provided by MGI
Primary source
MGI:MGI:1310002
See related
Ensembl:ENSMUSG00000040181 AllianceGenome:MGI:1310002
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables hypotaurine monooxygenase activity. Involved in taurine biosynthetic process. Acts upstream of or within energy homeostasis; negative regulation of fatty acid oxidation; and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in brain; cortical renal tubule; late tubule; and testis. Orthologous to human FMO1 (flavin containing dimethylaniline monoxygenase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 131.1), placenta adult (RPKM 107.8) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Fmo1 in Genome Data Viewer
Location:
1 H2.1; 1 70.34 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (162657130..162694170, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (162829561..162866610, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene proline-rich coiled-coil 2C Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:164658175-164658482 Neighboring gene STARR-positive B cell enhancer ABC_E1234 Neighboring gene STARR-seq mESC enhancer starr_02843 Neighboring gene STARR-seq mESC enhancer starr_02844 Neighboring gene flavin containing monooxygenase 4 Neighboring gene STARR-seq mESC enhancer starr_02845 Neighboring gene VISTA enhancer mm713 Neighboring gene STARR-seq mESC enhancer starr_02846 Neighboring gene predicted gene, 32197 Neighboring gene flavin containing monooxygenase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Flavin-containing monooxygenase 1 deficiency promotes neuroinflammation in dopaminergic neurons in mice. Li B, et al. Neurosci Lett, 2021 Nov 1. PMID 34500002
  2. Molecular cloning of mouse liver flavin containing monooxygenase (FMO1) cDNA and characterization of the expression product: metabolism of the neurotoxin, 1,2,3,4-tetrahydroisoquinoline (TIQ). Itoh K, et al. J Toxicol Sci, 1997 Feb. PMID 9076656
  3. Cell-, tissue-, sex- and developmental stage-specific expression of mouse flavin-containing monooxygenases (Fmos). Janmohamed A, et al. Biochem Pharmacol, 2004 Jul 1. PMID 15183119
  4. Determination of cellular localization of expression of flavin-containing monooxygenase genes in mouse tissues by in situ hybridization. Janmohamed A, et al. Methods Mol Biol, 2006. PMID 16719401
  5. Alternative promoters and repetitive DNA elements define the species-dependent tissue-specific expression of the FMO1 genes of human and mouse. Shephard EA, et al. Biochem J, 2007 Sep 15. PMID 17547558, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine.
    Title: Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine.
  2. Data indicate that in contrast to FMO2 and FMO4, FMO1 is highly expressed in metabolic tissues, including liver, kidney, white adipose tissue (WAT) and brown adipose tissue (BAT).
    Title: The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance.
  3. Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioral responses to imipramine.
    Title: Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine.
  4. The functional activity of Fmo1 was determined.
    Title: Functional activity of the mouse flavin-containing monooxygenase forms 1, 3, and 5.
  5. Fmo1, 2, 3, 4 and 5 exhibit distinct cell-, tissue-, sex- and developmental stage-specific patterns of expression.
    Title: Cell-, tissue-, sex- and developmental stage-specific expression of mouse flavin-containing monooxygenases (Fmos).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N,N-dimethylaniline monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N,N-dimethylaniline monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables N,N-dimethylaniline monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables hypotaurine monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hypotaurine monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables trimethylamine monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables trimethylamine monooxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in NADPH oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in NADPH oxidation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within energy homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of fatty acid oxidation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in organic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
involved_in taurine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in taurine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in toxin metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in toxin metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within xenobiotic metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
flavin-containing monooxygenase 1
Names
dimethylaniline monooxygenase [N-oxide-forming] 1
dimethylaniline oxidase 1
hepatic flavin-containing monooxygenase 1
trimethylamine monooxygenase
NP_001317220.1
NP_001317247.1
NP_001407099.1
NP_001407100.1
NP_001407101.1
NP_001407102.1
NP_001407103.1
NP_001407104.1
NP_034361.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330291.2 → NP_001317220.1  flavin-containing monooxygenase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    Consensus CDS
    CCDS15424.1
    UniProtKB/Swiss-Prot
    P50285
    Conserved Domains (1) summary
    pfam00743
    Location:3 → 532
    FMO-like; Flavin-binding monooxygenase-like

  2. NM_001330318.2 → NP_001317247.1  flavin-containing monooxygenase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    Consensus CDS
    CCDS87907.1
    UniProtKB/TrEMBL
    Q8C9C1
    Related
    ENSMUSP00000107143.2, ENSMUST00000111518.3
    Conserved Domains (1) summary
    pfam00743
    Location:3 → 161
    FMO-like; Flavin-binding monooxygenase-like

  3. NM_001420170.1 → NP_001407099.1  flavin-containing monooxygenase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    UniProtKB/Swiss-Prot
    P50285

  4. NM_001420171.1 → NP_001407100.1  flavin-containing monooxygenase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    UniProtKB/Swiss-Prot
    P50285

  5. NM_001420172.1 → NP_001407101.1  flavin-containing monooxygenase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    Related
    ENSMUSP00000118534.3, ENSMUST00000131058.8

  6. NM_001420173.1 → NP_001407102.1  flavin-containing monooxygenase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    Related
    ENSMUSP00000141210.2, ENSMUST00000193078.6

  7. NM_001420174.1 → NP_001407103.1  flavin-containing monooxygenase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    UniProtKB/TrEMBL
    Q8C9C1

  8. NM_001420175.1 → NP_001407104.1  flavin-containing monooxygenase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    UniProtKB/TrEMBL
    Q8C9C1

  9. NM_010231.4 → NP_034361.1  flavin-containing monooxygenase 1 isoform 1

    See identical proteins and their annotated locations for NP_034361.1

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    Consensus CDS
    CCDS15424.1
    UniProtKB/Swiss-Prot
    P50285
    Related
    ENSMUSP00000037259.8, ENSMUST00000046049.14
    Conserved Domains (1) summary
    pfam00743
    Location:3 → 532
    FMO-like; Flavin-binding monooxygenase-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    162657130..162694170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50285.1 GenPept UniProtKB/Swiss-Prot:P50285

Gene LinkOut

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