U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fmo1 flavin containing monooxygenase 1 [ Mus musculus (house mouse) ]

Gene ID: 14261, updated on 1-Mar-2024

Summary

Official Symbol
Fmo1provided by MGI
Official Full Name
flavin containing monooxygenase 1provided by MGI
Primary source
MGI:MGI:1310002
See related
Ensembl:ENSMUSG00000040181 AllianceGenome:MGI:1310002
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables monooxygenase activity. Acts upstream of or within xenobiotic metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in brain; cortical renal tubule; late tubule; and testis. Orthologous to human FMO1 (flavin containing dimethylaniline monoxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 131.1), placenta adult (RPKM 107.8) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Fmo1 in Genome Data Viewer
Location:
1 H2.1; 1 70.34 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (162657130..162694170, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (162829561..162866610, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene proline-rich coiled-coil 2C Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:164658175-164658482 Neighboring gene STARR-positive B cell enhancer ABC_E1234 Neighboring gene STARR-seq mESC enhancer starr_02843 Neighboring gene STARR-seq mESC enhancer starr_02844 Neighboring gene flavin containing monooxygenase 4 Neighboring gene STARR-seq mESC enhancer starr_02845 Neighboring gene VISTA enhancer mm713 Neighboring gene STARR-seq mESC enhancer starr_02846 Neighboring gene predicted gene, 32197 Neighboring gene flavin containing monooxygenase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N,N-dimethylaniline monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables N,N-dimethylaniline monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables hypotaurine dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables hypotaurine dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables monooxygenase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables trimethylamine monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in NADPH oxidation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within energy homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of fatty acid oxidation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in organic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in taurine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in taurine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in toxin metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within xenobiotic metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
flavin-containing monooxygenase 1
Names
dimethylaniline monooxygenase [N-oxide-forming] 1
dimethylaniline oxidase 1
hepatic flavin-containing monooxygenase 1
trimethylamine monooxygenase
NP_001317220.1
NP_001317247.1
NP_001407099.1
NP_001407100.1
NP_001407101.1
NP_001407102.1
NP_001407103.1
NP_001407104.1
NP_034361.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330291.2NP_001317220.1  flavin-containing monooxygenase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    Consensus CDS
    CCDS15424.1
    UniProtKB/Swiss-Prot
    P50285
    Conserved Domains (1) summary
    pfam00743
    Location:3532
    FMO-like; Flavin-binding monooxygenase-like
  2. NM_001330318.2NP_001317247.1  flavin-containing monooxygenase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    Consensus CDS
    CCDS87907.1
    UniProtKB/TrEMBL
    Q8C9C1
    Related
    ENSMUSP00000107143.2, ENSMUST00000111518.3
    Conserved Domains (1) summary
    pfam00743
    Location:3161
    FMO-like; Flavin-binding monooxygenase-like
  3. NM_001420170.1NP_001407099.1  flavin-containing monooxygenase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    UniProtKB/Swiss-Prot
    P50285
  4. NM_001420171.1NP_001407100.1  flavin-containing monooxygenase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    UniProtKB/Swiss-Prot
    P50285
  5. NM_001420172.1NP_001407101.1  flavin-containing monooxygenase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    UniProtKB/TrEMBL
    D3Z0T2
  6. NM_001420173.1NP_001407102.1  flavin-containing monooxygenase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    UniProtKB/TrEMBL
    D3Z0T2
  7. NM_001420174.1NP_001407103.1  flavin-containing monooxygenase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    UniProtKB/TrEMBL
    Q8C9C1
  8. NM_001420175.1NP_001407104.1  flavin-containing monooxygenase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    UniProtKB/TrEMBL
    Q8C9C1
  9. NM_010231.4NP_034361.1  flavin-containing monooxygenase 1 isoform 1

    See identical proteins and their annotated locations for NP_034361.1

    Status: VALIDATED

    Source sequence(s)
    AC117767, AC118643
    Consensus CDS
    CCDS15424.1
    UniProtKB/Swiss-Prot
    P50285
    Related
    ENSMUSP00000037259.8, ENSMUST00000046049.14
    Conserved Domains (1) summary
    pfam00743
    Location:3532
    FMO-like; Flavin-binding monooxygenase-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    162657130..162694170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)