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Fkbp5 FK506 binding protein 5 [ Mus musculus (house mouse) ]

Gene ID: 14229, updated on 20-Feb-2024

Summary

Official Symbol
Fkbp5provided by MGI
Official Full Name
FK506 binding protein 5provided by MGI
Primary source
MGI:MGI:104670
See related
Ensembl:ENSMUSG00000024222 AllianceGenome:MGI:104670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dit1; FKBP-5; FKBP51; D17Ertd592e
Summary
Predicted to enable heat shock protein binding activity and peptidyl-prolyl cis-trans isomerase activity. Acts upstream of or within response to bacterium. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; integumental system; and reproductive system. Human ortholog(s) of this gene implicated in major depressive disorder. Orthologous to human FKBP5 (FKBP prolyl isomerase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 58.3), genital fat pad adult (RPKM 40.8) and 21 other tissues See more
Orthologs
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Genomic context

See Fkbp5 in Genome Data Viewer
Location:
17 A3.3; 17 14.66 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28617727..28705123, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28398753..28486149, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene TEA domain family member 3 Neighboring gene STARR-seq mESC enhancer starr_42209 Neighboring gene TUB like protein 1 Neighboring gene STARR-seq mESC enhancer starr_42210 Neighboring gene predicted gene, 22146 Neighboring gene RIKEN cDNA E230001N04 gene Neighboring gene STARR-positive B cell enhancer ABC_E10942 Neighboring gene predicted gene, 41506 Neighboring gene armadillo repeat containing 12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP5
Names
51 kDa FK506-binding protein
51 kDa FKBP
PPIase FKBP5
rotamase
NP_034350.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010220.4NP_034350.1  peptidyl-prolyl cis-trans isomerase FKBP5

    See identical proteins and their annotated locations for NP_034350.1

    Status: VALIDATED

    Source sequence(s)
    AC154912, BU613862, BY740772, CF949740
    Consensus CDS
    CCDS37528.1
    UniProtKB/Swiss-Prot
    Q64378
    UniProtKB/TrEMBL
    Q3TX72, Q4FJN2
    Related
    ENSMUSP00000078382.4, ENSMUST00000079413.11
    Conserved Domains (5) summary
    smart00028
    Location:319350
    TPR; Tetratricopeptide repeats
    sd00006
    Location:319345
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:44135
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam00515
    Location:352384
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:319382
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    28617727..28705123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)