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Fhl2 four and a half LIM domains 2 [ Mus musculus (house mouse) ]

Gene ID: 14200, updated on 2-Nov-2024

Summary

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Official Symbol
Fhl2provided by MGI
Official Full Name
four and a half LIM domains 2provided by MGI
Primary source
MGI:MGI:1338762
See related
Ensembl:ENSMUSG00000008136 AllianceGenome:MGI:1338762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FHL-2; SLIM3; SLIM-3
Summary
This gene encodes a member of the four-and-a-half-LIM-only protein family. The encoded protein functions as a regulator in numerous signaling pathways and cellular processes in development and cellular differentiation, including development and maintenance of the cardiovascular system and striated muscles. This gene also plays a role in bone formation and regulates and bone mineral content and bone mineral density. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression
Biased expression in heart adult (RPKM 645.6) and bladder adult (RPKM 36.0) See more
Orthologs
human all
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Genomic context

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See Fhl2 in Genome Data Viewer
Location:
1 C1.1; 1 22.33 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (43162233..43237501, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (43123071..43198343, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene transforming growth factor, beta receptor associated protein 1 Neighboring gene RIKEN cDNA 8430432A02 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:43155317-43155426 Neighboring gene expressed sequence AI597479 Neighboring gene STARR-seq mESC enhancer starr_00773 Neighboring gene STARR-seq mESC enhancer starr_00774 Neighboring gene STARR-seq mESC enhancer starr_00775 Neighboring gene 60S ribosomal protein L29 Neighboring gene predicted gene 29040 Neighboring gene 60S ribosomal protein L17 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FHL2 Is Essential for Spleen T Cell-Dependent B Cell Activation and Antibody Response. Ebrahimian T, et al. Immunohorizons, 2020 May 20. PMID 32434880
  2. Inhibition of four-and-a-half LIM domain protein-2 increases survival, migratory capacity, and paracrine function of human early outgrowth cells through activation of the sphingosine kinase-1 pathway: implications for endothelial regeneration. Ebrahimian T, et al. Circ Res, 2014 Jan 3. PMID 24084691
  3. FHL2 (SLIM3) is not essential for cardiac development and function. Chu PH, et al. Mol Cell Biol, 2000 Oct. PMID 11003643, Free PMC Article
  4. Identification of FHL2-regulated genes in liver by microarray and bioinformatics analysis. Ng CF, et al. J Cell Biochem, 2014 Apr. PMID 24453047
  5. Disruption of four-and-a-half LIM 2 decreases bone mineral content and bone mineral density in femur and tibia bones of female mice. Govoni KE, et al. Calcif Tissue Int, 2006 Aug. PMID 16927043, Free PMC Article

See all (122) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere.
    Title: Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere.
  2. Proximal tubular FHL2, a novel downstream target of hypoxia inducible factor 1, is a protector against ischemic acute kidney injury.
    Title: Proximal tubular FHL2, a novel downstream target of hypoxia inducible factor 1, is a protector against ischemic acute kidney injury.
  3. Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity.
    Title: Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity.
  4. FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells.
    Title: FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells.
  5. CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes.
    Title: CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes.
  6. Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression marks human obesity.
    Title: Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression marks human obesity.
  7. FHL2 Is Essential for Spleen T Cell-Dependent B Cell Activation and Antibody Response.
    Title: FHL2 Is Essential for Spleen T Cell-Dependent B Cell Activation and Antibody Response.
  8. Deletion of the FHL2 gene attenuates intima-media thickening in a partially ligated carotid artery ligated mouse model.
    Title: Deletion of the FHL2 gene attenuates intima-media thickening in a partially ligated carotid artery ligated mouse model.
  9. LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis.
    Title: LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis.
  10. Four-And-A-Half LIM-Domain Protein 2 (FHL2) Deficiency Aggravates Cholestatic Liver Injury.
    Title: Four-And-A-Half LIM-Domain Protein 2 (FHL2) Deficiency Aggravates Cholestatic Liver Injury.
Submit: New GeneRIF Correction See all GeneRIFs (59)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bHLH transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in atrial cardiac muscle cell development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in heart trabecula formation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of calcineurin-NFAT signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of calcineurin-NFAT signaling cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in osteoblast differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to hormone IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
  
involved_in ventricular cardiac muscle cell development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in M band ISO
Inferred from Sequence Orthology
more info
  
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
four and a half LIM domains protein 2
Names
skeletal muscle LIM-protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289533.2 → NP_001276462.1  four and a half LIM domains protein 2

    See identical proteins and their annotated locations for NP_001276462.1

    Status: VALIDATED

    Source sequence(s)
    AC161207
    Consensus CDS
    CCDS14922.1
    UniProtKB/Swiss-Prot
    O70433, P97448
    UniProtKB/TrEMBL
    Q543D7
    Related
    ENSMUSP00000141170.2, ENSMUST00000185893.2
    Conserved Domains (2) summary
    cd09433
    Location:221 → 278
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:101 → 157
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. NM_001412598.1 → NP_001399527.1  four and a half LIM domains protein 2

    Status: VALIDATED

    Source sequence(s)
    AC161207
    UniProtKB/Swiss-Prot
    O70433, P97448
    UniProtKB/TrEMBL
    Q543D7

  3. NM_010212.5 → NP_034342.1  four and a half LIM domains protein 2

    See identical proteins and their annotated locations for NP_034342.1

    Status: VALIDATED

    Source sequence(s)
    AC161207
    Consensus CDS
    CCDS14922.1
    UniProtKB/Swiss-Prot
    O70433, P97448
    UniProtKB/TrEMBL
    Q543D7
    Related
    ENSMUSP00000008280.8, ENSMUST00000008280.14
    Conserved Domains (2) summary
    cd09433
    Location:221 → 278
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:101 → 157
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    43162233..43237501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70433.1 GenPept UniProtKB/Swiss-Prot:O70433

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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