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Fcna ficolin A [ Mus musculus (house mouse) ]

Gene ID: 14133, updated on 18-Apr-2024

Summary

Official Symbol
Fcnaprovided by MGI
Official Full Name
ficolin Aprovided by MGI
Primary source
MGI:MGI:1340905
See related
Ensembl:ENSMUSG00000026938 AllianceGenome:MGI:1340905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fcn1
Summary
Enables carbohydrate derivative binding activity. Acts upstream of or within complement activation, lectin pathway. Predicted to be extrinsic component of external side of plasma membrane. Predicted to be part of collagen trimer. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in brain; embryo; liver; and spleen. Orthologous to human FCN1 (ficolin 1) and FCN2 (ficolin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 38.4), spleen adult (RPKM 36.2) and 10 other tissues See more
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Genomic context

Location:
2 A3; 2 17.58 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25514677..25525448, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25624665..25635440, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 183 Neighboring gene ficolin A, opposite strand Neighboring gene transmembrane protein 141 Neighboring gene predicted gene, 35630 Neighboring gene lipocalin 15 Neighboring gene lipocalin 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables carbohydrate derivative binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in complement activation, lectin pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ficolin-1
Names
M-ficolin
collagen/fibrinogen domain-containing protein 1
ficolin-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420084.1NP_001407013.1  ficolin-1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL732590
  2. NM_007995.4NP_032021.1  ficolin-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032021.1

    Status: VALIDATED

    Source sequence(s)
    AL732590
    Consensus CDS
    CCDS15785.1
    UniProtKB/Swiss-Prot
    O70165
    UniProtKB/TrEMBL
    Q2WFW2, Q4FJM1
    Related
    ENSMUSP00000028307.9, ENSMUST00000028307.9
    Conserved Domains (2) summary
    pfam01391
    Location:65106
    Collagen; Collagen triple helix repeat (20 copies)
    cd00087
    Location:123332
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25514677..25525448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239016.4XP_011237318.1  ficolin-1 isoform X1

    See identical proteins and their annotated locations for XP_011237318.1

    UniProtKB/Swiss-Prot
    O70165
    UniProtKB/TrEMBL
    Q2WFW2, Q4FJM1
    Conserved Domains (2) summary
    pfam01391
    Location:65106
    Collagen; Collagen triple helix repeat (20 copies)
    cd00087
    Location:123332
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  2. XM_006497673.5XP_006497736.1  ficolin-1 isoform X1

    See identical proteins and their annotated locations for XP_006497736.1

    UniProtKB/Swiss-Prot
    O70165
    UniProtKB/TrEMBL
    Q2WFW2, Q4FJM1
    Conserved Domains (2) summary
    pfam01391
    Location:65106
    Collagen; Collagen triple helix repeat (20 copies)
    cd00087
    Location:123332
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...