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Fcgr3 Fc receptor, IgG, low affinity III [ Mus musculus (house mouse) ]

Gene ID: 14131, updated on 23-Jun-2021

Summary

Official Symbol
Fcgr3provided by MGI
Official Full Name
Fc receptor, IgG, low affinity IIIprovided by MGI
Primary source
MGI:MGI:95500
See related
Ensembl:ENSMUSG00000059498
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD16; Fcgam
Expression
Broad expression in placenta adult (RPKM 18.3), testis adult (RPKM 15.7) and 27 other tissues See more
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Genomic context

See Fcgr3 in Genome Data Viewer
Location:
1 H3; 1 78.8 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170878738..170893476, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171051169..171065915, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (172981300..172989534, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA leucine 3 (anticodon CAG) Neighboring gene nuclear encoded tRNA glycine 4 (anticodon GCC) Neighboring gene nuclear encoded tRNA glutamic acid 5 (anticodon CTC) Neighboring gene nuclear encoded tRNA glycine 1 (anticodon TCC) Neighboring gene microRNA 6546 Neighboring gene nuclear encoded tRNA aspartic acid 3 (anticodon GTC) Neighboring gene nuclear encoded tRNA glycine 12 (anticodon GCC) Neighboring gene nuclear encoded tRNA leucine 6 (anticodon CAG)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables IgG binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables IgG receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables IgG receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within antibody-dependent cellular cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mast cell activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mast cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phagocytosis, recognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of type I hypersensitivity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of type I hypersensitivity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of type III hypersensitivity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of type IIa hypersensitivity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within serotonin secretion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
low affinity immunoglobulin gamma Fc region receptor III
Names
Fc gamma receptor III
Fcg receptor III
FcgammaRIII
fc-gamma RIII
fcRIII
igG Fc receptor III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356511.1NP_001343440.1  low affinity immunoglobulin gamma Fc region receptor III isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC115959, AC117796
    Consensus CDS
    CCDS87919.1
    Related
    ENSMUSP00000131836.2, ENSMUST00000169017.8
    Conserved Domains (2) summary
    cd05753
    Location:122204
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cl11960
    Location:40118
    Ig; Immunoglobulin domain
  2. NM_010188.5NP_034318.2  low affinity immunoglobulin gamma Fc region receptor III isoform 1 precursor

    See identical proteins and their annotated locations for NP_034318.2

    Status: VALIDATED

    Source sequence(s)
    AC115959, AK151557, BY199827
    Consensus CDS
    CCDS15477.2
    UniProtKB/TrEMBL
    A0A0B4J1M6
    Related
    ENSMUSP00000131938.2, ENSMUST00000164044.8
    Conserved Domains (2) summary
    cd05753
    Location:123205
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cl11960
    Location:41119
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    170878738..170893476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496659.5XP_006496722.1  low affinity immunoglobulin gamma Fc region receptor III isoform X1

    See identical proteins and their annotated locations for XP_006496722.1

    UniProtKB/TrEMBL
    A0A0B4J1M6
    Conserved Domains (2) summary
    cd05753
    Location:123205
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cl11960
    Location:41119
    Ig; Immunoglobulin domain
  2. XM_006496660.2XP_006496723.1  low affinity immunoglobulin gamma Fc region receptor III isoform X2

    See identical proteins and their annotated locations for XP_006496723.1

    UniProtKB/TrEMBL
    E9PUV2
    Conserved Domains (2) summary
    cd05753
    Location:122204
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cl11960
    Location:40118
    Ig; Immunoglobulin domain
  3. XM_030247672.2XP_030103532.1  low affinity immunoglobulin gamma Fc region receptor III isoform X1

    Conserved Domains (2) summary
    cd05753
    Location:123205
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cl11960
    Location:41119
    Ig; Immunoglobulin domain
  4. XM_030247708.1XP_030103568.1  low affinity immunoglobulin gamma Fc region receptor III isoform X1

    Conserved Domains (2) summary
    cd05753
    Location:123205
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cl11960
    Location:41119
    Ig; Immunoglobulin domain
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