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Fcgr2b Fc receptor, IgG, low affinity IIb [ Mus musculus (house mouse) ]

Gene ID: 14130, updated on 8-Dec-2022

Summary

Official Symbol
Fcgr2bprovided by MGI
Official Full Name
Fc receptor, IgG, low affinity IIbprovided by MGI
Primary source
MGI:MGI:95499
See related
Ensembl:ENSMUSG00000026656 AllianceGenome:MGI:95499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD32; Fcgr2; Fcr-2; Fcr-3; Ly-17; LyM-1; Lym-1; fcRII; FcgRII; Fcgr2a; Ly-m20; Fc[g]RII; F630109E10Rik
Summary
Enables IgG binding activity. Involved in several processes, including cellular response to amyloid-beta; nervous system development; and regulation of cellular response to stress. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of immune effector process; and regulation of phagocytosis. Located in cell body; dendritic spine; and external side of plasma membrane. Is integral component of membrane. Is expressed in liver and spleen. Used to study malaria and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to several human genes including FCGR2B (Fc fragment of IgG receptor IIb). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 19.1), spleen adult (RPKM 16.7) and 21 other tissues See more
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Genomic context

See Fcgr2b in Genome Data Viewer
Location:
1 H3; 1 78.02 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170788127..170803691, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170960558..170976071, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Fc receptor-like A Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene Neighboring gene predicted gene, 39701 Neighboring gene predicted gene, 34968 Neighboring gene predicted gene 10522

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables IgG binding IDA
Inferred from Direct Assay
more info
PubMed 
enables IgG binding ISO
Inferred from Sequence Orthology
more info
 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables immunoglobulin binding ISO
Inferred from Sequence Orthology
more info
 
enables low-affinity IgG receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Fc receptor-mediated immune complex endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to amyloid-beta IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to molecule of bacterial origin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune complex clearance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immunoglobulin mediated immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within mast cell activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of acute inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of humoral immune response mediated by circulating immunoglobulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neutrophil apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of type I hypersensitivity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phagocytosis, engulfment IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dendritic spine maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
low affinity immunoglobulin gamma Fc region receptor II-b
Names
Fc gamma RIIB
Fc-gamma-RII
FcgammaRIIB
fc gamma receptor IIB
fc-gamma RII
fc-gamma-RIIB
igG Fc receptor II beta
low affinity immunoglobulin gamma Fc region receptor II
lymphocyte antigen 17

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077189.1NP_001070657.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 1

    See identical proteins and their annotated locations for NP_001070657.1

    Status: VALIDATED

    Source sequence(s)
    AK150613, AK171316, CD773836
    Consensus CDS
    CCDS35770.1
    UniProtKB/TrEMBL
    A0A0B4J1E6
    Related
    ENSMUSP00000027966.8, ENSMUST00000027966.14
    Conserved Domains (3) summary
    cd05753
    Location:128210
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:134210
    IG_like; Immunoglobulin like
    cl11960
    Location:46124
    Ig; Immunoglobulin domain
  2. NM_010187.2NP_034317.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 2

    See identical proteins and their annotated locations for NP_034317.1

    Status: VALIDATED

    Source sequence(s)
    AK150613, AK171316, CD773836
    Consensus CDS
    CCDS35769.1
    UniProtKB/Swiss-Prot
    P08101
    UniProtKB/TrEMBL
    A0A0B4J1G1
    Related
    ENSMUSP00000079882.6, ENSMUST00000081103.12
    Conserved Domains (2) summary
    smart00410
    Location:134210
    IG_like; Immunoglobulin like
    cl11960
    Location:128210
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    170788127..170803691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159814.1XP_036015707.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform X1