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Fbl fibrillarin [ Mus musculus (house mouse) ]

Gene ID: 14113, updated on 27-Feb-2024

Summary

Official Symbol
Fblprovided by MGI
Official Full Name
fibrillarinprovided by MGI
Primary source
MGI:MGI:95486
See related
Ensembl:ENSMUSG00000046865 AllianceGenome:MGI:95486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FIB; FLRN; RNU3IP1
Summary
Enables RNA binding activity. Acts upstream of or within sno(s)RNA metabolic process. Located in Cajal body and granular component. Is expressed in several structures, including central nervous system; early conceptus; neural retina; oocyte; and submandibular gland primordium. Orthologous to human FBL (fibrillarin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 132.0), liver E14 (RPKM 128.6) and 28 other tissues See more
Orthologs
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Genomic context

See Fbl in Genome Data Viewer
Location:
7 A3; 7 16.67 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27868293..27878701)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28168893..28179269)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene tectorin alpha pseudogene Neighboring gene predicted gene, 38976 Neighboring gene Fc fragment of IgG binding protein like 1 Neighboring gene STARR-seq mESC enhancer starr_18401 Neighboring gene STARR-seq mESC enhancer starr_18402 Neighboring gene STARR-positive B cell enhancer ABC_E6526 Neighboring gene predicted gene, 31024 Neighboring gene STARR-positive B cell enhancer ABC_E9687 Neighboring gene dual-specificity tyrosine phosphorylation regulated kinase 1b Neighboring gene STARR-seq mESC enhancer starr_18404 Neighboring gene STARR-seq mESC enhancer starr_18406 Neighboring gene STARR-seq mESC enhancer starr_18407 Neighboring gene STARR-seq mESC enhancer starr_18408 Neighboring gene ring finger and WD repeat domain 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables TFIID-class transcription factor complex binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H2AQ104 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H2AQ104 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables rRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in box C/D RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in rRNA methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sno(s)RNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in snoRNA localization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Cajal body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
 
part_of box C/D RNP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in dense fibrillar component ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in granular component IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rRNA 2'-O-methyltransferase fibrillarin
Names
U6 snRNA 2'-O-methyltransferase fibrillarin
histone-glutamine methyltransferase
nucleolar protein 1
NP_001399349.1
NP_032017.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412420.1NP_001399349.1  rRNA 2'-O-methyltransferase fibrillarin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC141883
  2. NM_007991.4NP_032017.2  rRNA 2'-O-methyltransferase fibrillarin isoform 1

    See identical proteins and their annotated locations for NP_032017.2

    Status: VALIDATED

    Source sequence(s)
    AC141883
    Consensus CDS
    CCDS21036.1
    UniProtKB/Swiss-Prot
    P35550, Q99L58
    UniProtKB/TrEMBL
    Q3UJS2
    Related
    ENSMUSP00000037613.7, ENSMUST00000042405.8
    Conserved Domains (1) summary
    PTZ00146
    Location:88326
    PTZ00146; fibrillarin; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    27868293..27878701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)