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Fabp2 fatty acid binding protein 2, intestinal [ Mus musculus (house mouse) ]

Gene ID: 14079, updated on 1-Mar-2024

Summary

Official Symbol
Fabp2provided by MGI
Official Full Name
fatty acid binding protein 2, intestinalprovided by MGI
Primary source
MGI:MGI:95478
See related
Ensembl:ENSMUSG00000023057 AllianceGenome:MGI:95478
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fabpi; I-FABP
Summary
The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. This protein functions within enterocytes, possibly to sense lipids as part of energy homeostasis. In humans polymorphisms are associated with increased fat oxidation and insulin resistance. In mice deficiency of this gene alters body weight in a gender-specific manner and causes hyperinsulinemia. [provided by RefSeq, Jan 2013]
Expression
Biased expression in large intestine adult (RPKM 347.4), small intestine adult (RPKM 41.6) and 1 other tissue See more
Orthologs
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Genomic context

See Fabp2 in Genome Data Viewer
Location:
3 G1; 3 53.74 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (122688721..122693155)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (122895072..122899506)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 5A, cGMP-specific Neighboring gene predicted gene, 34577 Neighboring gene RIKEN cDNA 4933405D12 gene Neighboring gene anaphase-promoting complex subunit 15 pseudogene Neighboring gene RIKEN cDNA 1810037I17 gene Neighboring gene STARR-seq mESC enhancer starr_08897 Neighboring gene STARR-positive B cell enhancer ABC_E6116 Neighboring gene ubiquitin specific peptidase 53 Neighboring gene STARR-seq mESC enhancer starr_08899

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables long-chain fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
enables long-chain fatty acid transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intestinal absorption ISO
Inferred from Sequence Orthology
more info
 
involved_in intestinal lipid absorption ISO
Inferred from Sequence Orthology
more info
 
involved_in long-chain fatty acid transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
fatty acid-binding protein, intestinal
Names
intestinal fatty acid binding protein 2
intestinal-type fatty acid-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007980.3NP_032006.1  fatty acid-binding protein, intestinal

    See identical proteins and their annotated locations for NP_032006.1

    Status: REVIEWED

    Source sequence(s)
    AA245078, AK007995, BY707992
    Consensus CDS
    CCDS17813.1
    UniProtKB/Swiss-Prot
    P55050
    UniProtKB/TrEMBL
    Q53YP5
    Related
    ENSMUSP00000023820.6, ENSMUST00000023820.6
    Conserved Domains (1) summary
    pfam00061
    Location:5132
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    122688721..122693155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)