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Sesn1 sestrin 1 [ Mus musculus (house mouse) ]

Gene ID: 140742, updated on 12-May-2024

Summary

Official Symbol
Sesn1provided by MGI
Official Full Name
sestrin 1provided by MGI
Primary source
MGI:MGI:2155278
See related
Ensembl:ENSMUSG00000038332 AllianceGenome:MGI:2155278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pa26; Sest1; 1110002G11Rik
Summary
Predicted to enable leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Involved in cellular response to amino acid stimulus; negative regulation of TORC1 signaling; and negative regulation of cell growth. Acts upstream of or within regulation of protein kinase B signaling. Predicted to be located in cytoplasm; fibrillar center; and nucleoplasm. Predicted to be part of GATOR2 complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human SESN1 (sestrin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 16.1), large intestine adult (RPKM 14.7) and 28 other tissues See more
Orthologs
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Genomic context

See Sesn1 in Genome Data Viewer
Location:
10 B2; 10 22.77 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (41686570..41784432)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (41810574..41908436)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 162 Neighboring gene STARR-positive B cell enhancer ABC_E5128 Neighboring gene microRNA 3473b Neighboring gene centrosomal protein 57-like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:41472075-41472184 Neighboring gene cDNA sequence BC048559 Neighboring gene STARR-seq mESC enhancer starr_26466 Neighboring gene STARR-seq mESC enhancer starr_26467 Neighboring gene STARR-seq mESC enhancer starr_26468 Neighboring gene STARR-seq mESC enhancer starr_26469 Neighboring gene STARR-seq mESC enhancer starr_26471 Neighboring gene STARR-seq mESC enhancer starr_26472 Neighboring gene armadillo repeat containing 2 Neighboring gene annexin A2 pseudogene Neighboring gene predicted gene, 33058

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (5)  1 citation

General gene information

Markers

Clone Names

  • MGC118148

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-leucine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-leucine binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on peroxide as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular oxidant detoxification ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to L-leucine IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amino acid stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to leucine starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of response to reactive oxygen species IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of GATOR2 complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sestrin-1
Names
p53 regulated Pa26 nuclear protein
p53-regulated protein PA26
NP_001013388.2
NP_001156380.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013370.2NP_001013388.2  sestrin-1 isoform 2

    See identical proteins and their annotated locations for NP_001013388.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK160083, BB338086, BC055753, BY126656
    Consensus CDS
    CCDS23809.1
    UniProtKB/Swiss-Prot
    E9QPK0, P58006, Q7TNF3
    UniProtKB/TrEMBL
    V5QRJ1
    Related
    ENSMUSP00000043034.7, ENSMUST00000041438.7
    Conserved Domains (1) summary
    pfam04636
    Location:47491
    PA26; PA26 p53-induced protein (sestrin)
  2. NM_001162908.1NP_001156380.1  sestrin-1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK160083, BB338086, BC100403
    Consensus CDS
    CCDS48550.1
    UniProtKB/TrEMBL
    E9PXR3, Q497S6
    Related
    ENSMUSP00000097515.4, ENSMUST00000099931.11
    Conserved Domains (1) summary
    pfam04636
    Location:106550
    PA26; PA26 p53-induced protein (sestrin)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    41686570..41784432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)