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SUN5 Sad1 and UNC84 domain containing 5 [ Homo sapiens (human) ]

Gene ID: 140732, updated on 3-Feb-2021

Summary

Official Symbol
SUN5provided by HGNC
Official Full Name
Sad1 and UNC84 domain containing 5provided by HGNC
Primary source
HGNC:HGNC:16252
See related
Ensembl:ENSG00000167098 MIM:613942
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPAG4L; SPGF16; TSARG4; dJ726C3.1
Summary
The protein encoded by this gene appears to play a role in the meiotic stage of spermatogenesis. The encoded protein localizes to the junction between the sperm head and body and may be involved in nuclear envelope reconstitution and nuclear migration. Mutations in this gene have been implicated in acephalic spermatozoa syndrome. [provided by RefSeq, May 2017]
Expression
Restricted expression toward testis (RPKM 7.9) See more
Orthologs
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Genomic context

See SUN5 in Genome Data Viewer
Location:
20q11.21
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (32983773..33004449, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (31571581..31592239, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 8 Neighboring gene VISTA enhancer hs2101 Neighboring gene BPI fold containing family B member 2 Neighboring gene BPI fold containing family B member 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33594

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
nuclear envelope organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
meiotic nuclear membrane microtubule tethering complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
sperm connecting piece IDA
Inferred from Direct Assay
more info
PubMed 
sperm connecting piece ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
SUN domain-containing protein 5
Names
epididymis secretory sperm binding protein
sad1 and UNC84 domain-containing protein 5
sperm-associated antigen 4-like protein
testis and spermatogenesis related gene 4
testis and spermatogenesis-related gene 4 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054760.1 RefSeqGene

    Range
    5017..25675
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080675.4NP_542406.2  SUN domain-containing protein 5

    See identical proteins and their annotated locations for NP_542406.2

    Status: REVIEWED

    Source sequence(s)
    BC026118
    Consensus CDS
    CCDS13209.1
    UniProtKB/Swiss-Prot
    Q8TC36
    Related
    ENSP00000348496.3, ENST00000356173.8
    Conserved Domains (1) summary
    pfam07738
    Location:231363
    Sad1_UNC; Sad1 / UNC-like C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    32983773..33004449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528574.1XP_011526876.1  SUN domain-containing protein 5 isoform X2

    UniProtKB/TrEMBL
    A9Z1W8
    Related
    ENSP00000364673.3, ENST00000375523.7
    Conserved Domains (1) summary
    pfam07738
    Location:206338
    Sad1_UNC; Sad1 / UNC-like C-terminal
  2. XM_011528573.1XP_011526875.1  SUN domain-containing protein 5 isoform X1

    Conserved Domains (1) summary
    pfam07738
    Location:254386
    Sad1_UNC; Sad1 / UNC-like C-terminal
  3. XM_011528575.1XP_011526877.1  SUN domain-containing protein 5 isoform X3

    Conserved Domains (1) summary
    pfam07738
    Location:141273
    Sad1_UNC; Sad1 / UNC-like C-terminal
  4. XM_011528576.1XP_011526878.1  SUN domain-containing protein 5 isoform X4

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